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YWHAE [cytosol]
Stable Identifier
R-HSA-194368
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
14-3-3 protein epsilon, 143E_HUMAN, 14-3-3 epsilon
Locations in the PathwayBrowser for interactor UniProt:Q13671%20RIN1
Expand all
Disease (Homo sapiens)
Diseases of programmed cell death (Homo sapiens)
Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
Neurodegenerative Diseases (Homo sapiens)
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
CDC25C binds YWHAE (14-3-3-epsilon) (Homo sapiens)
YWHAE [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62258 YWHAE
Gene Names
YWHAE
Chain
chain:1-255
Reference Genes
BioGPS Gene:7531 YWHAE
COSMIC (genes):YWHAE YWHAE
CTD Gene:7531 YWHAE
dbSNP Gene:7531 YWHAE
ENSEMBL:ENSG00000108953 YWHAE
ENSEMBL:ENSG00000274474 YWHAE
ENSEMBL_homo_sapiens_GENE:ENSG00000108953.17 YWHAE
ENSEMBL_homo_sapiens_GENE:ENSG00000274474.3 YWHAE
HGNC:12851 YWHAE
KEGG Gene (Homo sapiens):7531 YWHAE
Monarch:7531 YWHAE
NCBI Gene:7531 YWHAE
OMIM:605066 YWHAE
UCSC:P62258 YWHAE
Reference Transcript
RefSeq:NM_006761.4 YWHAE
Other Identifiers
1011_s_at
11739011_s_at
11753092_s_at
11753517_s_at
11753518_x_at
11758309_s_at
210317_PM_s_at
210317_s_at
210996_PM_s_at
210996_s_at
2578538
3052111
3052117
3740125
3740127
3740128
3740129
3740130
3740131
3740132
3740133
3740134
3740135
3740139
3740141
3740143
3740144
3740147
3740148
3740149
3740156
3740157
3740158
3752151
7531
8011011
8055476
A_23_P72285
A_24_P123011
A_24_P123012
GE59242
GO:0000165
GO:0000278
GO:0001764
GO:0002376
GO:0002753
GO:0003013
GO:0003064
GO:0003723
GO:0005246
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005925
GO:0006605
GO:0006886
GO:0006913
GO:0007165
GO:0007346
GO:0015459
GO:0016020
GO:0019899
GO:0019903
GO:0019904
GO:0021762
GO:0021766
GO:0021987
GO:0023026
GO:0023052
GO:0030154
GO:0031410
GO:0031625
GO:0031966
GO:0034504
GO:0034605
GO:0035308
GO:0035556
GO:0035591
GO:0036211
GO:0042470
GO:0042802
GO:0042826
GO:0043226
GO:0044325
GO:0045296
GO:0046827
GO:0046982
GO:0048856
GO:0048870
GO:0050815
GO:0051219
GO:0051480
GO:0055065
GO:0055085
GO:0060090
GO:0060306
GO:0070062
GO:0086013
GO:0086091
GO:0097110
GO:0098542
GO:0098772
GO:0140311
GO:0140313
GO:1901016
GO:1901020
GO:1902309
GO:1905913
HMNXSV003007677
HMNXSV003029125
ILMN_1807535
ILMN_2252136
PH_hs_0029000
PH_hs_0031355
TC17000972.hg
TC17002434.hg
U54778_at
g4096984_3p_a_at
g984318_3p_a_at
Participates
as a component of
centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
mother centriole [cytosol] (Homo sapiens)
CDC25C:YWHAE [cytosol] (Homo sapiens)
Nlp-depleted centrosome [cytosol] (Homo sapiens)
centrosome containing phosphorylated Nlp [cytosol] (Homo sapiens)
cNAP-1 depleted centrosome [cytosol] (Homo sapiens)
YWHAE dimer [cytosol] (Homo sapiens)
centrosome [cytosol] (Homo sapiens)
as an input of
CDC25C binds YWHAE (14-3-3-epsilon) (Homo sapiens)
Inferred To
rad24 [cytosol]
(Schizosaccharomyces pombe)
fe38c12 [cytosol]
(Danio rerio)
14-3-3 epsilon [cytosol]
(Mus musculus)
rad25 [cytosol]
(Schizosaccharomyces pombe)
Ywhae [cytosol]
(Rattus norvegicus)
ywhae [cytosol]
(Xenopus tropicalis)
BMH2 [cytosol]
(Saccharomyces cerevisiae)
YWHAE [cytosol]
(Bos taurus)
YWHAE [cytosol]
(Canis familiaris)
YWHAE [cytosol]
(Gallus gallus)
YWHAE [cytosol]
(Sus scrofa)
fttB [cytosol]
(Dictyostelium discoideum)
14-3-3epsilon [cytosol]
(Drosophila melanogaster)
Homologues of YWHAE [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_006752.1
OpenTargets
ENSG00000108953
HPA
ENSG00000108953-YWHAE
GeneCards
P62258
Ensembl
ENSP00000461762
,
ENST00000571732
,
ENSP00000487356
,
ENSG00000274474
,
ENST00000627231
,
ENST00000264335
,
ENST00000616643
,
ENSP00000481059
,
ENSP00000264335
,
ENSG00000108953
PRO
P62258
Pharos - Targets
P62258
Orphanet
20276
PDB
8DGP
,
8DGM
,
2BR9
,
7V9B
,
3UAL
,
7C8E
,
3UBW
,
8DP5
,
8DGN
,
6EIH
Interactors (166)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.922
13
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.907
14
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.903
22
UniProt:P54253 ATX1
0.888
14
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.872
11
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.853
12
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.84
10
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.823
8
UniProt:P56524 HDAC4
3
polySUMO2,3-K559-HDAC4 [nucleoplasm]
(R-HSA-4616029)
monoSUMO1-K559-HDAC4 [nucleoplasm]
(R-HSA-4616016)
HDAC4 [nucleoplasm]
(R-HSA-351581)
0.823
8
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.816
9
UniProt:P46937 YAP1
7
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
YAP1 [cytosol]
(R-HSA-1253345)
YAP1 [nucleoplasm]
(R-HSA-1253322)
0.797
8
UniProt:Q92934 BAD
4
p-S99-BAD [cytosol]
(R-HSA-198335)
BAD [cytosol]
(R-HSA-50662)
BAD [mitochondrial outer membrane]
(R-HSA-114242)
p-S91-BAD [cytosol]
(R-HSA-217297)
0.783
7
UniProt:Q9Y2U5 M3K2
0.775
6
UniProt:P35568 IRS1
5
p-Y-IRS1 [plasma membrane]
(R-HSA-198366)
p-Y-IRS1 [cytosol]
(R-HSA-74772)
IRS1 [cytosol]
(R-HSA-74769)
IRS1 [plasma membrane]
(R-HSA-2425392)
p-6Y-IRS1 [plasma membrane]
(R-HSA-2445090)
0.76
8
UniProt:O15151 MDM4
5
PolyUb-MDM4 [nucleoplasm]
(R-HSA-6782502)
PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm]
(R-HSA-6804938)
p-S346,S367,S403-MDM4 [nucleoplasm]
(R-HSA-349441)
p-S403-MDM4 [nucleoplasm]
(R-HSA-349461)
MDM4 [nucleoplasm]
(R-HSA-349430)
0.758
5
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S582 ARAF [cytosol]
(R-HSA-5672646)
p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
(R-HSA-5672648)
p-S582 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S582 ARAF [cytosol]
(R-HSA-5672639)
0.752
7
UniProt:Q99759 MAP3K3
1
MAP3K3 [cytosol]
(R-HSA-507725)
0.744
5
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.734
5
UniProt:P27448 MARK3
1
MARK3 [cytosol]
(R-HSA-5672591)
0.727
7
UniProt:P30307 CDC25C
8
p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol]
(R-HSA-8863654)
p-S191-CDC25C [nucleoplasm]
(R-HSA-6802968)
p-S216-CDC25C [cytosol]
(R-HSA-75003)
p-S216-CDC25C [nucleoplasm]
(R-HSA-156496)
CDC25C [nucleoplasm]
(R-HSA-69741)
CDC25C [cytosol]
(R-HSA-157879)
p-S198-CDC25C [cytosol]
(R-HSA-8981697)
p-S198-CDC25C [nucleoplasm]
(R-HSA-156668)
0.708
5
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.708
5
UniProt:O96013 PAK4
1
PAK4 [cytosol]
(R-HSA-428461)
0.695
8
UniProt:P00519 ABL1
5
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
0.695
5
UniProt:P30305 CDC25B
3
p-S50,T69,S160,S321,S470-CDC25B [cytosol]
(R-HSA-8863644)
CDC25B [cytosol]
(R-HSA-157412)
CDC25B [nucleoplasm]
(R-HSA-69734)
0.692
5
UniProt:P30304 CDC25A
6
PolyUb-CDC25A [cytosol]
(R-HSA-6782810)
CDC25A [nucleoplasm]
(R-HSA-143487)
CDC25A [cytosol]
(R-HSA-157410)
p-S124-CDC25A [nucleoplasm]
(R-HSA-143488)
p-S124-CDC25A [cytosol]
(R-HSA-69588)
p-S40,S116,S261-CDC25A [nucleoplasm]
(R-HSA-8863634)
0.69
5
UniProt:Q5SW79 CE170
0.676
5
UniProt:P08069 IGF1R
3
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
0.669
6
UniProt:Q9NQU5 PAK6
1
PAK6 [cytosol]
(R-HSA-428454)
0.669
4
UniProt:Q13470 TNK1
0.669
4
UniProt:Q00536 CDK16
0.669
4
UniProt:P57059 SIK1
1
SIK1 [nucleoplasm]
(R-HSA-5656504)
0.669
4
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.667
3
UniProt:Q7L804 RAB11FIP2
1
RAB11FIP2 [cytoplasmic vesicle membrane]
(R-HSA-2028707)
0.659
5
UniProt:Q13671 RIN1
1
RIN1 [cytosol]
(R-HSA-8875287)
0.659
3
UniProt:Q9GZV5 WWTR1
3
p-S89-WWTR1 [cytosol]
(R-HSA-2028665)
WWTR1 [nucleoplasm]
(R-HSA-1629775)
WWTR1 [cytosol]
(R-HSA-1629773)
0.659
3
UniProt:Q99469 STAC
0.656
3
UniProt:O43896 KIF1C
1
KIF1C [cytosol]
(R-HSA-8849365)
0.655
5
UniProt:Q6IQ23 PKHA7
0.649
6
UniProt:O14654 IRS4
2
p-Y-IRS4 [plasma membrane]
(R-HSA-2424302)
IRS4 [plasma membrane]
(R-HSA-2424297)
0.649
6
UniProt:Q96PU5 NEDD4L
2
NEDD4L [cytosol]
(R-HSA-976003)
NEDD4L [nucleoplasm]
(R-HSA-2176420)
0.649
5
UniProt:Q7KZI7 MARK2
0.643
3
UniProt:Q9Y3M2 CBY1
3
pS20-CBY1 [nucleoplasm]
(R-HSA-3769356)
CBY1 [nucleoplasm]
(R-HSA-3769210)
pS20-CBY1 [cytosol]
(R-HSA-3769354)
0.638
4
UniProt:Q9NRR6 INPP5E
2
INPP5E [cilium]
(R-HSA-5624872)
INPP5E [cytosol]
(R-HSA-1604585)
0.638
4
UniProt:O94921 CDK14
0.632
4
UniProt:O92972-PRO_0000278742
0.625
5
UniProt:Q13233 MAP3K1
2
MAP3K1 [cytosol]
(R-HSA-166866)
p-T1400,T1412-MAP3K1 [cytosol]
(R-HSA-2685607)
0.621
3
UniProt:Q9H4A3 WNK1
1
WNK1 [cytosol]
(R-HSA-2672391)
0.618
6
UniProt:Q6R327 RICTOR
1
RICTOR [cytosol]
(R-HSA-198632)
0.615
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
18
UniProt:Q9UKT5 FBXO4
1
FBXO4 [cytosol]
(R-HSA-391298)
0.612
5
UniProt:Q96S53 TESK2
0.604
4
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.604
5
UniProt:O43524 FOXO3
9
p-S215 FOXO3 [nucleoplasm]
(R-HSA-5687010)
p-S215 FOXO3 [cytosol]
(R-HSA-5687014)
FOXO3 [cytosol]
(R-HSA-5687032)
p-S43,S173,S294,S325-FOXO3 [nucleoplasm]
(R-HSA-8870627)
p-S43,S173,S294,S325-FOXO3 [cytosol]
(R-HSA-8870560)
Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm]
(R-HSA-9620514)
p-T32,S253,S315-FOXO3 [cytosol]
(R-HSA-9614413)
p-T32,S253,S315-FOXO3 [nucleoplasm]
(R-HSA-199289)
FOXO3 [nucleoplasm]
(R-HSA-199305)
0.604
4
UniProt:Q14678-2 KANK1
0.602
3
UniProt:O94875 SRBS2
0.594
4
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.573
3
UniProt:P49815 TSC2
4
p-S939,S1130,T1462-TSC2 [cytosol]
(R-HSA-165164)
p-S939,T1462-TSC2 [cytosol]
(R-HSA-199484)
TSC2 [cytosol]
(R-HSA-2980548)
p-S1387-TSC2 [cytosol]
(R-HSA-3132769)
0.571
2
UniProt:Q5TCX8 M3K21
0.569
4
UniProt:Q5VZ89 DENND4C
1
DENND4C [cytosol]
(R-HSA-5216192)
0.569
4
UniProt:Q9Y2K2 SIK3
0.569
4
UniProt:P26045 PTPN3
3
PTPN3 [plasma membrane]
(R-HSA-5490317)
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [cytosol]
(R-HSA-8867650)
0.569
3
UniProt:Q9Y4H2 IRS2
4
IRS2 [plasma membrane]
(R-HSA-2428927)
IRS2 [cytosol]
(R-HSA-57528)
p-Y-IRS2 [cytosol]
(R-HSA-74774)
p-Y-IRS2 [plasma membrane]
(R-HSA-198334)
0.569
4
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
11
UniProt:P19484 TFEB
1
TFEB [nucleoplasm]
(R-HSA-9857368)
0.564
2
UniProt:Q5U5Q3 MEX3C
1
MEX3C [cytosol]
(R-HSA-8851640)
0.564
3
UniProt:Q8N5S9 CAMKK1
4
p-CAMKK1 [nucleoplasm]
(R-HSA-444232)
CAMKK1 [nucleoplasm]
(R-HSA-442775)
CAMKK1 [cytosol]
(R-HSA-9619232)
p-CAMKK1 [cytosol]
(R-HSA-9619356)
0.564
3
UniProt:O75494 SRSF10
1
SRSF10 [nucleoplasm]
(R-HSA-8866646)
0.564
3
UniProt:Q5PRF9 SMAG2
0.564
3
UniProt:Q9P286 PAK5
2
PAK7 [plasma membrane]
(R-HSA-211555)
PAK5 [cytosol]
(R-HSA-428459)
0.564
3
UniProt:Q96N96 SPATA13
1
SPATA13 [cytosol]
(R-HSA-9690931)
0.564
3
UniProt:Q02156 PRKCE
2
p-T566,T710,S729-PRKCE [plasma membrane]
(R-HSA-198260)
PRKCE [cytosol]
(R-HSA-58202)
0.564
4
UniProt:Q8N568 DCLK2
0.564
3
UniProt:P46934 NEDD4
1
NEDD4 [cytosol]
(R-HSA-975992)
0.564
3
UniProt:Q70EL4 USP43
1
USP43 [nucleoplasm]
(R-HSA-5653784)
0.564
2
UniProt:P58340 MLF1
0.558
3
UniProt:Q86Z20 CC125
0.556
3
UniProt:P56524-2 HDAC4
0.556
3
UniProt:Q08981 ACM1
0.556
3
UniProt:Q06251 YL177
0.556
3
UniProt:Q9NRI5 DISC1
0.553
3
UniProt:Q9H0I2 ENKD1
0.547
2
UniProt:Q13111 CAF1A
0.547
2
UniProt:Q15884 EREP1
0.547
2
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.547
2
UniProt:Q9NSK0 KLC4
1
KLC4 [cytosol]
(R-HSA-983244)
0.539
5
UniProt:Q6UUV9 CRTC1
1
CRTC1 [nucleoplasm]
(R-HSA-5656488)
0.539
4
UniProt:Q8N8E3 CE112
0.539
4
UniProt:Q7Z460 CLASP1
1
CLASP1 [cytosol]
(R-HSA-376230)
0.539
5
UniProt:Q92974 ARHGEF2
1
ARHGEF2 [cytosol]
(R-HSA-195101)
0.539
5
UniProt:O60333 KIF1B
1
KIF1B [cytosol]
(R-HSA-8849378)
0.539
5
UniProt:O14639 ABLIM1
1
ABLIM1 [cytosol]
(R-HSA-416771)
0.539
6
UniProt:O75122 CLASP2
1
CLASP2 [cytosol]
(R-HSA-376252)
0.539
6
UniProt:Q9H0B6 KLC2
1
KLC2 [cytosol]
(R-HSA-983191)
0.539
5
UniProt:Q86W92 PPFIBP1
5
PPFIBP1 [cytosol]
(R-HSA-6799300)
PPFIBP1(1-349)insK-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711955)
PPFIBP1(1-232)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711976)
PPFIBP1(1-232)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711963)
PPFIBP1(1-349)insK-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711961)
0.539
4
UniProt:Q9UQB8 BAIAP2
1
BAIAP2 [cytosol]
(R-HSA-442574)
0.539
5
UniProt:Q6PKG0 LARP1
1
LARP1 [cytosol]
(R-HSA-9760421)
0.539
5
UniProt:Q14671 PUM1
1
PUM1 [cytosol]
(R-HSA-434211)
0.539
5
UniProt:Q9NYJ8 TAB2
4
TAB2 [cytosol]
(R-HSA-168117)
TAB2 [endosome membrane]
(R-HSA-450279)
TAB2 [plasma membrane]
(R-HSA-168116)
TAB2 [nucleoplasm]
(R-HSA-1253323)
0.536
2
UniProt:Q6VAB6 KSR2
1
KSR2 [cytosol]
(R-HSA-5672589)
0.527
6
UniProt:Q9Y2J2 EPB41L3
1
EPB41L3 [cytosol]
(R-HSA-6797563)
0.527
2
UniProt:O43900 PRIC3
0.527
2
UniProt:Q9UJM3 ERRFI
0.527
2
UniProt:Q53ET0 CRTC2
1
CRTC2 [nucleoplasm]
(R-HSA-8931951)
0.527
3
UniProt:Q9UQL6 HDAC5
1
HDAC5 [nucleoplasm]
(R-HSA-3004533)
0.527
3
UniProt:P50749 RASF2
0.527
2
UniProt:Q9H0K1 SIK2
0.527
2
UniProt:Q00613 HSF1
11
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
HSF1 [nucleoplasm]
(R-HSA-5082385)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
HSF1 [cytosol]
(R-HSA-3371452)
0.527
2
UniProt:Q61337 Bad
6
phospho-Bad [cytosol]
(R-MMU-217297)
Bad [mitochondrial outer membrane]
(R-MMU-114242)
p-S136-Bad [cytosol]
(R-MMU-3139049)
Bad [cytosol]
(R-MMU-3139043)
Bad [cytosol]
(R-MMU-50662)
phospho-Bad [cytosol]
(R-MMU-198335)
0.527
2
UniProt:Q02750 MAP2K1
20
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
MAP2K1 Q56P [cytosol]
(R-HSA-9652064)
MAP2K1 E203K [cytosol]
(R-HSA-9652023)
MAP2K1 V60E [cytosol]
(R-HSA-9652067)
MAP2K1 P124S [cytosol]
(R-HSA-9652062)
MAP2K1 Y130C [cytosol]
(R-HSA-9652101)
MAP2K1 C121S [cytosol]
(R-HSA-9652013)
MAP2K1 G128V [cytosol]
(R-HSA-9652047)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 L42_K57del [cytosol]
(R-HSA-9652026)
0.527
3
UniProt:Q9BZ23 PANK2
1
PANK2(111-570) [mitochondrial intermembrane space]
(R-HSA-196803)
0.527
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
3
UniProt:Q0VF96 CGNL1
0.519
3
UniProt:P28290 ITPI2
0.519
3
UniProt:Q96GE4 CEP95
0.519
2
UniProt:Q9P0V3 SH3BP4
1
SH3BP4 [cytosol]
(R-HSA-8866227)
0.519
3
UniProt:P61962 DCAF7
2
DCAF7 [nucleoplasm]
(R-HSA-8863312)
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
0.508
3
UniProt:Q96AP0 ACD
1
ACD [nucleoplasm]
(R-HSA-174889)
0.508
2
UniProt:Q96QF0 RAB3IP
1
RAB3IP [cytosol]
(R-HSA-5617610)
0.508
3
UniProt:Q07002 CDK18
0.499
3
UniProt:Q6ICG6 K0930
0.499
3
UniProt:Q15154 PCM1
1
PCM1 [cytosol]
(R-HSA-380308)
0.499
3
UniProt:Q7Z6J0 SH3RF1
1
SH3RF1 [cytosol]
(R-HSA-5688968)
0.499
3
UniProt:O00257-3 CBX4
0.499
2
UniProt:O43491 EPB41L2
1
EPB41L2 [cytosol]
(R-HSA-6797548)
0.499
3
UniProt:P09622 DLD
1
DLD [mitochondrial matrix]
(R-HSA-69978)
0.499
5
UniProt:P80192 M3K9
0.499
3
UniProt:Q00537 CDK17
0.499
3
UniProt:P36957 DLST
4
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853502)
LipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853485)
DLST [mitochondrial matrix]
(R-HSA-6792574)
0.499
4
UniProt:Q12778 FOXO1
5
p-S218-FOXO1 [nucleoplasm]
(R-HSA-5692651)
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
(R-HSA-9626942)
FOXO1 [nucleoplasm]
(R-HSA-199300)
p-T24,S256,S319-FOXO1 [nucleoplasm]
(R-HSA-199306)
p-T24,S256,S319-FOXO1 [cytosol]
(R-HSA-211158)
0.499
4
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.499
3
UniProt:P21796 VDAC1
4
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
0.499
5
UniProt:P49840 GSK3A
3
GSK3A [cytosol]
(R-HSA-198326)
p-S21-GSK3A [cytosol]
(R-HSA-198352)
p-Y279-GSK3A [cytosol]
(R-HSA-9635490)
0.499
3
UniProt:O95696 BRD1
1
BRD1 [nucleoplasm]
(R-HSA-3318450)
0.483
2
UniProt:Q7Z309 PBIR2
0.483
2
UniProt:Q9P2M7 CGN
1
CGN [cell junction]
(R-HSA-2134478)
0.483
3
UniProt:Q6P1L5 F117B
0.483
3
UniProt:P85299 PRR5
1
PRR5 [cytosol]
(R-HSA-6795323)
0.483
3
UniProt:Q9HCD6 TANC2
0.483
4
UniProt:Q9P1Y5 CAMP3
0.483
2
UniProt:Q3V6T2 CCDC88A
1
CCDC88A [cytosol]
(R-HSA-9715191)
0.483
3
UniProt:Q86X29 LSR
1
LSR [plasma membrane]
(R-HSA-8933138)
0.483
3
UniProt:Q96NE9 FRMD6
0.483
2
UniProt:O14924 RGS12
1
RGS12 [plasma membrane]
(R-HSA-939784)
0.483
3
UniProt:Q08495 DMTN
1
DMTN [cytosol]
(R-HSA-5216222)
0.483
2
UniProt:Q9UQC2 GAB2
5
p-Y643-GAB2 [cytosol]
(R-HSA-9677149)
p-5Y-GAB2 [cytosol]
(R-HSA-8855574)
p-Y-GAB2 [cytosol]
(R-HSA-912529)
p-Y452,Y476,Y584-GAB2 [cytosol]
(R-HSA-2685615)
GAB2 [cytosol]
(R-HSA-508239)
0.483
3
UniProt:Q96ST8 CEP89
1
CEP89 [cytosol]
(R-HSA-5620930)
0.483
4
UniProt:O00429 DNM1L
2
DNM1L [mitochondrial outer membrane]
(R-HSA-351942)
DNM1L [cytosol]
(R-HSA-351943)
0.483
4
UniProt:Q99959 PKP2
2
PKP2 [cornified envelope]
(R-HSA-8847734)
PKP2 [plasma membrane]
(R-HSA-6814393)
0.471
4
UniProt:Q8IVT5 KSR1
5
p-S311,S406 KSR1 [cytosol]
(R-HSA-5672654)
KSR1 [cytosol]
(R-HSA-5672587)
p-S311 KSR1 [cytosol]
(R-HSA-5672652)
p-S311,Y602 KSR1 [plasma membrane]
(R-HSA-5672659)
p-S311,Y602 KSR1 [cytosol]
(R-HSA-5672656)
0.471
3
UniProt:O60343 TBC1D4
2
p-5S,T642-TBC1D4 [cytoplasmic vesicle membrane]
(R-HSA-1445101)
TBC1D4 [cytoplasmic vesicle membrane]
(R-HSA-1445122)
0.471
4
UniProt:Q86V48 LUZP1
0.471
3
UniProt:Q9Y3R0 GRIP1
2
GRIP1 [cytosol]
(R-HSA-416633)
GRIP1 [plasma membrane]
(R-HSA-416638)
0.471
3
UniProt:O43379 WDR62
0.471
4
UniProt:O35244
3
Prdx6 [extracellular region]
(R-RNO-6806198)
Prdx6 [azurophil granule lumen]
(R-RNO-6798744)
Prdx6 [cytosol]
(R-RNO-3343670)
0.471
2
UniProt:Q8NEY1 NAV1
0.471
4
UniProt:Q9UPU9 SMAG1
0.471
3
UniProt:Q6P0Q8 MAST2
0.471
3
UniProt:Q8N4C8 MINK1
1
MINK1 [cytosol]
(R-HSA-2532788)
0.471
3
UniProt:Q5VV41 ARHGEF16
1
ARHGEF16 [cytosol]
(R-HSA-2976623)
0.471
4
UniProt:P40818 USP8
2
p-T945-USP8 [cytosol]
(R-HSA-1358714)
USP8 [cytosol]
(R-HSA-917720)
0.471
4
UniProt:P47974 ZFP36L2
1
ZFP36L2 [cytosol]
(R-HSA-9819194)
0.471
4
UniProt:Q51451 Q51451
0.469
2
UniProt:P51957-2 NEK4
0.462
2
UniProt:P51957-1 NEK4
0.462
2
UniProt:Q76353 Q76353
0.462
2
UniProt:Q6PJG9 LRFN4
1
SALM3 [plasma membrane]
(R-HSA-197883)
0.462
3
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