Reactome | YWHAE [cytosol]

YWHAE [cytosol]

Stable Identifier

R-HSA-194368

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

14-3-3 protein epsilon, 143E_HUMAN, 14-3-3 epsilon

Locations in the PathwayBrowser for interactor UniProt:Q6P1L5 F117B

Expand all

Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Neurodegenerative Diseases (Homo sapiens)
      - Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
        
        CDC25C binds YWHAE (14-3-3-epsilon) (Homo sapiens)
        
        YWHAE [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62258 YWHAE

Gene Names

YWHAE

Chain

chain:1-255

Reference Genes

BioGPS Gene:7531 YWHAE

COSMIC (genes):YWHAE YWHAE

CTD Gene:7531 YWHAE

dbSNP Gene:7531 YWHAE

ENSEMBL:ENSG00000108953 YWHAE

ENSEMBL:ENSG00000274474 YWHAE

ENSEMBL_homo_sapiens_GENE:ENSG00000108953.17 YWHAE

ENSEMBL_homo_sapiens_GENE:ENSG00000274474.3 YWHAE

HGNC:12851 YWHAE

KEGG Gene (Homo sapiens):7531 YWHAE

Monarch:7531 YWHAE

NCBI Gene:7531 YWHAE

OMIM:605066 YWHAE

UCSC:P62258 YWHAE

Reference Transcript

RefSeq:NM_006761.4 YWHAE

Other Identifiers

1011_s_at

11739011_s_at

11753092_s_at

11753517_s_at

11753518_x_at

11758309_s_at

210317_PM_s_at

210317_s_at

210996_PM_s_at

210996_s_at

2578538

3052111

3052117

3740125

3740127

3740128

3740129

3740130

3740131

3740132

3740133

3740134

3740135

3740139

3740141

3740143

3740144

3740147

3740148

3740149

3740156

3740157

3740158

3752151

7531

8011011

8055476

A_23_P72285

A_24_P123011

A_24_P123012

GE59242

GO:0000165

GO:0000278

GO:0001764

GO:0002376

GO:0002753

GO:0003013

GO:0003064

GO:0003723

GO:0005246

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0005925

GO:0006605

GO:0006886

GO:0006913

GO:0007165

GO:0007346

GO:0015459

GO:0016020

GO:0019899

GO:0019903

GO:0019904

GO:0021762

GO:0021766

GO:0021987

GO:0023026

GO:0023052

GO:0030154

GO:0031410

GO:0031625

GO:0031966

GO:0034504

GO:0034605

GO:0035308

GO:0035556

GO:0035591

GO:0036211

GO:0042470

GO:0042802

GO:0042826

GO:0043226

GO:0044325

GO:0045296

GO:0046827

GO:0046982

GO:0048856

GO:0048870

GO:0050815

GO:0051219

GO:0051480

GO:0055065

GO:0055085

GO:0060090

GO:0060306

GO:0070062

GO:0086013

GO:0086091

GO:0097110

GO:0098542

GO:0098772

GO:0140311

GO:0140313

GO:1901016

GO:1901020

GO:1902309

GO:1905913

HMNXSV003007677

HMNXSV003029125

ILMN_1807535

ILMN_2252136

PH_hs_0029000

PH_hs_0031355

TC17000972.hg

TC17002434.hg

U54778_at

g4096984_3p_a_at

g984318_3p_a_at

Participates

as a component of

as an input of

CDC25C binds YWHAE (14-3-3-epsilon) (Homo sapiens)

Inferred To

rad24 [cytosol] (Schizosaccharomyces pombe)

ywhae1 [cytosol] (Danio rerio)

14-3-3 epsilon [cytosol] (Mus musculus)

rad25 [cytosol] (Schizosaccharomyces pombe)

Ywhae [cytosol] (Rattus norvegicus)

ywhae [cytosol] (Xenopus tropicalis)

BMH2 [cytosol] (Saccharomyces cerevisiae)

YWHAE [cytosol] (Bos taurus)

YWHAE [cytosol] (Canis familiaris)

YWHAE [cytosol] (Gallus gallus)

YWHAE [cytosol] (Sus scrofa)

fttB [cytosol] (Dictyostelium discoideum)

14-3-3epsilon [cytosol] (Drosophila melanogaster)

Homologues of YWHAE [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_006752.1

OpenTargets

ENSG00000108953

HPA

ENSG00000108953-YWHAE

GeneCards

P62258

Ensembl

ENSG00000108953, ENST00000627231, ENSP00000481059, ENST00000616643, ENSP00000461762, ENSP00000264335, ENSP00000487356, ENSG00000274474, ENST00000571732, ENST00000264335

PRO

P62258

Pharos - Targets

P62258

Orphanet

20276

PDB

8DP5, 8DGM, 3UAL, 2BR9, 6EIH, 8DGP, 8Q1S, 7V9B, 3UBW, 7C8E, 8DGN

Interactors (291)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.94	17
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.924	17
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.919	15
UniProt:P54253 ATX1			0.919	15
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.916	14
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.913	24
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.91	13
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.865	9
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.859	10
UniProt:P46937 YAP1	8	p-Y407-YAP1 [cytosol] (R-HSA-9865208) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.842	9
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.833	8
UniProt:Q9Y2U5 M3K2			0.825	7
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.823	8
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.809	8
UniProt:Q99759 MAP3K3	1	MAP3K3 [cytosol] (R-HSA-507725)	0.802	6
UniProt:P27448 MARK3	1	MARK3 [cytosol] (R-HSA-5672591)	0.786	9
UniProt:P30307 CDC25C	8	p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) CDC25C [nucleoplasm] (R-HSA-69741) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [cytosol] (R-HSA-8981697) p-S198-CDC25C [nucleoplasm] (R-HSA-156668)	0.773	6
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.773	6
UniProt:O96013 PAK4	1	PAK4 [cytosol] (R-HSA-428461)	0.763	10
UniProt:P30305 CDC25B	3	p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644) CDC25B [cytosol] (R-HSA-157412) CDC25B [nucleoplasm] (R-HSA-69734)	0.763	6
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.763	6
UniProt:P35568 IRS1	5	p-Y-IRS1 [plasma membrane] (R-HSA-198366) p-Y-IRS1 [cytosol] (R-HSA-74772) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.76	8
UniProt:P30304 CDC25A	6	PolyUb-CDC25A [cytosol] (R-HSA-6782810) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S124-CDC25A [nucleoplasm] (R-HSA-143488) p-S124-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634)	0.76	6
UniProt:O15151 MDM4	5	PolyUb-MDM4 [nucleoplasm] (R-HSA-6782502) p-S403-MDM4 [nucleoplasm] (R-HSA-349461) p-S346,S367,S403-MDM4 [nucleoplasm] (R-HSA-349441) PolyUb,p-S342,S367,S403-MDM4 [nucleoplasm] (R-HSA-6804938) MDM4 [nucleoplasm] (R-HSA-349430)	0.758	5
UniProt:Q9NQU5 PAK6	1	PAK6 [cytosol] (R-HSA-428454)	0.744	5
UniProt:Q5PRF9 SMAG2			0.744	6
UniProt:P19484 TFEB	1	TFEB [nucleoplasm] (R-HSA-9857368)	0.744	5
UniProt:Q00536 CDK16			0.744	5
UniProt:Q13671 RIN1	1	RIN1 [cytosol] (R-HSA-8875287)	0.738	4
UniProt:Q9GZV5 WWTR1	3	p-S89-WWTR1 [cytosol] (R-HSA-2028665) WWTR1 [cytosol] (R-HSA-1629773) WWTR1 [nucleoplasm] (R-HSA-1629775)	0.738	4
UniProt:Q7L804 RAB11FIP2	1	RAB11FIP2 [cytoplasmic vesicle membrane] (R-HSA-2028707)	0.737	6
UniProt:O43896 KIF1C	1	KIF1C [cytosol] (R-HSA-8849365)	0.734	6
UniProt:Q99469 STAC			0.734	4
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.734	5
UniProt:Q6IQ23 PKHA7			0.727	7
UniProt:Q96PU5 NEDD4L	2	NEDD4L [cytosol] (R-HSA-976003) NEDD4L [nucleoplasm] (R-HSA-2176420)	0.727	6
UniProt:Q7KZI7 MARK2			0.725	5
UniProt:Q9UJM3 ERRFI			0.725	4
UniProt:Q9NRR6 INPP5E	2	INPP5E [cilium] (R-HSA-5624872) INPP5E [cytosol] (R-HSA-1604585)	0.725	5
UniProt:Q9Y3M2 CBY1	3	pS20-CBY1 [nucleoplasm] (R-HSA-3769356) CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.725	5
UniProt:Q13233 MAP3K1	2	MAP3K1 [cytosol] (R-HSA-166866) p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607)	0.71	4
UniProt:Q6ICG6 K0930			0.708	5
UniProt:Q9H4A3 WNK1	1	WNK1 [cytosol] (R-HSA-2672391)	0.707	7
UniProt:Q6R327 RICTOR	1	RICTOR [cytosol] (R-HSA-198632)	0.706	5
UniProt:Q7Z309 PBIR2			0.706	4
UniProt:Q9P2M7 CGN	1	CGN [cell junction] (R-HSA-2134478)	0.706	5
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239)	0.706	5
UniProt:O60343 TBC1D4	2	p-5S,T642-TBC1D4 [cytoplasmic vesicle membrane] (R-HSA-1445101) TBC1D4 [cytoplasmic vesicle membrane] (R-HSA-1445122)	0.695	6
UniProt:Q96S53 TESK2			0.695	5
UniProt:O43524 FOXO3	11	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) FOXO3 [nucleoplasm] (R-HSA-199305)	0.695	5
UniProt:Q5SW79 CE170			0.676	5
UniProt:P49815 TSC2	4	p-S939,S1130,T1462-TSC2 [cytosol] (R-HSA-165164) p-S939,T1462-TSC2 [cytosol] (R-HSA-199484) TSC2 [cytosol] (R-HSA-2980548) p-S1387-TSC2 [cytosol] (R-HSA-3132769)	0.675	3
UniProt:Q5TCX8 M3K21			0.671	5
UniProt:Q9Y2K2 SIK3			0.671	5
UniProt:Q5VZ89 DENND4C	1	DENND4C [cytosol] (R-HSA-5216192)	0.671	5
UniProt:P26045 PTPN3	3	PTPN3 [plasma membrane] (R-HSA-5490317) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [cytosol] (R-HSA-8867650)	0.671	4
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.669	6
UniProt:Q13470 TNK1			0.669	4
UniProt:Q96N96 SPATA13	1	SPATA13 [cytosol] (R-HSA-9690931)	0.669	4
UniProt:Q6P597 KLC3	1	KLC3 [cytosol] (R-HSA-983232)	0.669	4
UniProt:P57059 SIK1	1	SIK1 [nucleoplasm] (R-HSA-5656504)	0.669	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.667	3
UniProt:Q13111 CAF1A			0.659	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.659	3
UniProt:Q9NSK0 KLC4	1	KLC4 [cytosol] (R-HSA-983244)	0.649	6
UniProt:Q7Z460 CLASP1	1	CLASP1 [cytosol] (R-HSA-376230)	0.649	7
UniProt:O60333 KIF1B	1	KIF1B [cytosol] (R-HSA-8849378)	0.649	6
UniProt:O75122 CLASP2	1	CLASP2 [cytosol] (R-HSA-376252)	0.649	8
UniProt:Q86W92 PPFIBP1	5	PPFIBP1 [cytosol] (R-HSA-6799300) PPFIBP1(1-349)insK-ALK(1058-1620) fusion [cytosol] (R-HSA-9711955) PPFIBP1(1-232)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711976) PPFIBP1(1-232)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711963) PPFIBP1(1-349)insK-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711961)	0.649	5
UniProt:Q6UUV9 CRTC1	1	CRTC1 [nucleoplasm] (R-HSA-5656488)	0.649	5
UniProt:O14654 IRS4	2	p-Y-IRS4 [plasma membrane] (R-HSA-2424302) IRS4 [plasma membrane] (R-HSA-2424297)	0.649	6
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.649	6
UniProt:O14639 ABLIM1	1	ABLIM1 [cytosol] (R-HSA-416771)	0.649	7
UniProt:Q9H0B6 KLC2	1	KLC2 [cytosol] (R-HSA-983191)	0.649	6
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.649	7
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.649	6
UniProt:Q6VAB6 KSR2	1	KSR2 [cytosol] (R-HSA-5672589)	0.643	7
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.643	3
UniProt:O43900 PRIC3			0.643	5
UniProt:Q53ET0 CRTC2	1	CRTC2 [nucleoplasm] (R-HSA-8931951)	0.643	4
UniProt:Q9UQL6 HDAC5	1	HDAC5 [nucleoplasm] (R-HSA-3004533)	0.643	4
UniProt:Q9BZ23 PANK2	1	PANK2(111-570) [mitochondrial intermembrane space] (R-HSA-196803)	0.643	3
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026)	0.643	5
UniProt:P28290 ITPI2			0.64	4
UniProt:Q96GE4 CEP95			0.64	3
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.64	4
UniProt:O94921 CDK14			0.632	4
UniProt:O92972-PRO_0000278742			0.625	5
UniProt:Q07002 CDK18			0.623	4
UniProt:Q00537 CDK17			0.623	4
UniProt:Q12778 FOXO1	5	p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651) Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) FOXO1 [nucleoplasm] (R-HSA-199300) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158)	0.623	5
UniProt:Q3V6T2 CCDC88A	1	CCDC88A [cytosol] (R-HSA-9715191)	0.615	4
UniProt:Q5JXC2 MIIP			0.615	3
UniProt:O14924 RGS12	1	RGS12 [plasma membrane] (R-HSA-939784)	0.615	4
UniProt:Q9P1Y5 CAMP3			0.615	3
UniProt:Q969F2 NKD2			0.615	3
UniProt:Q96NE9 FRMD6			0.615	3
UniProt:O60292 SI1L3			0.615	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	18
UniProt:Q08495 DMTN	1	DMTN [cytosol] (R-HSA-5216222)	0.615	3
UniProt:Q9UKT5 FBXO4	1	FBXO4 [cytosol] (R-HSA-391298)	0.612	5
UniProt:Q99959 PKP2	2	PKP2 [cornified envelope] (R-HSA-8847734) PKP2 [plasma membrane] (R-HSA-6814393)	0.604	5
UniProt:Q9UPU9 SMAG1			0.604	5
UniProt:Q8IVT5 KSR1	5	p-S311,S406 KSR1 [cytosol] (R-HSA-5672654) KSR1 [cytosol] (R-HSA-5672587) p-S311 KSR1 [cytosol] (R-HSA-5672652) p-S311,Y602 KSR1 [plasma membrane] (R-HSA-5672659) p-S311,Y602 KSR1 [cytosol] (R-HSA-5672656)	0.604	4
UniProt:Q9Y3R0 GRIP1	2	GRIP1 [cytosol] (R-HSA-416633) GRIP1 [plasma membrane] (R-HSA-416638)	0.604	4
UniProt:O43379 WDR62			0.604	5
UniProt:Q6P0Q8 MAST2			0.604	4
UniProt:P40818 USP8	2	USP8 [cytosol] (R-HSA-917720) p-T945-USP8 [cytosol] (R-HSA-1358714)	0.604	5
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.604	5
UniProt:P47974 ZFP36L2	1	ZFP36L2 [cytosol] (R-HSA-9819194)	0.604	5
UniProt:Q14678-2 KANK1			0.602	3
UniProt:O94875 SRBS2			0.594	4
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.573	3
UniProt:Q8NHQ8 RASF8			0.569	4
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.569	11
UniProt:Q9Y6R0 NUMBL			0.569	3
UniProt:Q92625 ANS1A			0.569	3
UniProt:Q7Z401 DENND4A	1	DENND4A [cytosol] (R-HSA-8876072)	0.569	5
UniProt:Q96N67 DOCK7	1	DOCK7 [cytosol] (R-HSA-1012970)	0.569	4
UniProt:Q5TCZ1 SH3PXD2A	1	SH3PXD2A [cytosol] (R-HSA-8941242)	0.569	4
UniProt:Q12923 PTPN13	2	PTPN13 [plasma membrane] (R-HSA-8870318) PTPN13 [nucleoplasm] (R-HSA-9008915)	0.569	4
UniProt:P78524 ST5	1	ST5 [cytosol] (R-HSA-8876091)	0.569	3
UniProt:Q86SQ0 PHLB2			0.569	4
UniProt:Q9NYL2 M3K20			0.569	3
UniProt:Q9P2F8 SI1L2			0.569	4
UniProt:Q6WKZ4 RFIP1			0.569	4
UniProt:Q6ZV73 FGD6			0.569	3
UniProt:Q13625 TP53BP2	1	TP53BP2 [nucleoplasm] (R-HSA-6799780)	0.569	4
UniProt:Q8TEW0 PARD3	3	PARD3 [plasma membrane] (R-HSA-419980) PARD3 [cytosol] (R-HSA-419993) PARD3 [cell junction] (R-HSA-2134481)	0.569	5
UniProt:O15049 N4BP3			0.569	4
UniProt:Q9HAU0 PLEKHA5	1	PLEKHA5 [plasma membrane] (R-HSA-8870498)	0.569	4
UniProt:Q3KQU3 MA7D1			0.569	3
UniProt:Q86TI0 TBC1D1	2	TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718) p-S237-TBC1D1 [cytosol] (R-HSA-1454673)	0.569	4
UniProt:Q9Y4H2 IRS2	4	IRS2 [plasma membrane] (R-HSA-2428927) IRS2 [cytosol] (R-HSA-57528) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.569	4
UniProt:P49757 NUMB	1	NUMB [plasma membrane] (R-HSA-443595)	0.569	4
UniProt:Q02241 KIF23	3	KIF23 [nucleoplasm] (R-HSA-156709) p-S911,S912-KIF23 [nucleoplasm] (R-HSA-156695) KIF23 [cytosol] (R-HSA-1015863)	0.569	4
UniProt:O00443 PIK3C2A	3	PIK3C2A [Golgi membrane] (R-HSA-432679) PIK3C2A [cytosol] (R-HSA-1604624) PIK3C2A [cytoplasmic vesicle membrane] (R-HSA-432683)	0.569	4
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.564	3
UniProt:O75494 SRSF10	1	SRSF10 [nucleoplasm] (R-HSA-8866646)	0.564	3
UniProt:Q9P286 PAK5	2	PAK7 [plasma membrane] (R-HSA-211555) PAK5 [cytosol] (R-HSA-428459)	0.564	3
UniProt:Q8TC76 F110B			0.564	3
UniProt:Q13322 GRB10	2	p-Y GRB10 [cytosol] (R-HSA-9706168) GRB10 [cytosol] (R-HSA-110009)	0.564	3
UniProt:O00444 PLK4	1	PLK4 [cytosol] (R-HSA-380286)	0.564	3
UniProt:Q5U5Q3 MEX3C	1	MEX3C [cytosol] (R-HSA-8851640)	0.564	3
UniProt:Q86UK7 ZN598			0.564	3
UniProt:Q8N5S9 CAMKK1	4	p-CAMKK1 [nucleoplasm] (R-HSA-444232) CAMKK1 [nucleoplasm] (R-HSA-442775) CAMKK1 [cytosol] (R-HSA-9619232) p-CAMKK1 [cytosol] (R-HSA-9619356)	0.564	3
UniProt:Q86X27 RGPS2			0.564	3
UniProt:Q9NXR1 NDE1	1	NDE1 [cytosol] (R-HSA-376257)	0.564	3
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.564	4
UniProt:Q8N568 DCLK2			0.564	3
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.564	3
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.564	3
UniProt:P58340 MLF1			0.558	3
UniProt:P56524-2 HDAC4			0.556	3
UniProt:Q06251 YL177			0.556	3
UniProt:Q86Z20 CC125			0.556	3
UniProt:Q08981 ACM1			0.556	3
UniProt:Q9NRI5 DISC1			0.553	3
UniProt:Q9H0I2 ENKD1			0.547	2
UniProt:Q15884 EREP1			0.547	2
UniProt:Q8N8E3 CE112			0.539	4
UniProt:Q14671 PUM1	1	PUM1 [cytosol] (R-HSA-434211)	0.539	5
UniProt:Q9NYJ8 TAB2	4	TAB2 [cytosol] (R-HSA-168117) TAB2 [endosome membrane] (R-HSA-450279) TAB2 [plasma membrane] (R-HSA-168116) TAB2 [nucleoplasm] (R-HSA-1253323)	0.536	2
UniProt:Q9NYF3 FA53C			0.527	2
UniProt:Q9BQK8 LPIN3	3	p-S106-LPIN3 [nucleoplasm] (R-HSA-4419935) LPIN3 [nuclear envelope] (R-HSA-4419928) LPIN3 [endoplasmic reticulum membrane] (R-HSA-549160)	0.527	2
UniProt:Q6ZW31 SYDE1	1	SYDE1 [cytosol] (R-HSA-2980861)	0.527	2
UniProt:Q8ND76 CCNY			0.527	2
UniProt:Q13112 CAF1B			0.527	3
UniProt:Q9Y2H9 MAST1			0.527	2
UniProt:Q8IZ21 PHAR4			0.527	3
UniProt:P11274 BCR	4	BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838979) p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839041) BCR(1-584)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604524) BCR [cytosol] (R-HSA-195200)	0.527	2
UniProt:Q14680 MELK			0.527	2
UniProt:Q96GL9 F163A			0.527	2
UniProt:Q8TC71 MIEAP			0.527	2
UniProt:P50749 RASF2			0.527	2
UniProt:Q9Y2L9 LRCH1			0.527	2
UniProt:Q9H0K1 SIK2			0.527	2
UniProt:Q9NZQ3 NCKIPSD	1	NCKIPSD [cytosol] (R-HSA-2197671)	0.527	2
UniProt:Q5VWQ8 DAB2IP	1	DAB2IP [cytosol] (R-HSA-5658238)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	3
UniProt:P57078 RIPK4			0.527	2
UniProt:Q86X02 CDR2L			0.527	4
UniProt:Q15139 PRKD1	1	PRKD1 [cytosol] (R-HSA-58210)	0.527	2
UniProt:Q15032 R3HD1			0.527	2
UniProt:Q96Q42 ALS2	1	ALS2 [cytosol] (R-HSA-8875298)	0.527	2
UniProt:Q9H8N7 ZN395			0.527	3
UniProt:Q6NUK4 REEP3			0.527	2
UniProt:Q9HB19 PLEKHA2	1	PLEKHA2 [plasma membrane] (R-HSA-8870329)	0.527	2
UniProt:Q14153 FA53B			0.527	2
UniProt:Q9P0L2 MARK1			0.527	2
UniProt:O60825 PFKFB2	1	PFKFB2 [cytosol] (R-HSA-71790)	0.527	3
UniProt:Q07866 KLC1	3	KLC1(1-420)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711978) KLC1(1-420)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711968) KLC1 [cytosol] (R-HSA-983284)	0.527	2
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.527	3
UniProt:Q9Y4G8 RAPGEF2	1	RAPGEF2 [cytosol] (R-HSA-5672599)	0.527	2
UniProt:Q9ULR3 PPM1H			0.527	2
UniProt:Q8TEU7 RPGF6			0.527	3
UniProt:Q96GV9 MACIR			0.527	2
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.527	5
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.527	2
UniProt:Q70EL4 USP43	1	USP43 [nucleoplasm] (R-HSA-5653784)	0.527	2
UniProt:Q00613 HSF1	11	p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) HSF1 [cytosol] (R-HSA-3371452)	0.527	2
UniProt:Q61337 Bad	6	phospho-Bad [cytosol] (R-MMU-217297) Bad [mitochondrial outer membrane] (R-MMU-114242) p-S136-Bad [cytosol] (R-MMU-3139049) Bad [cytosol] (R-MMU-3139043) Bad [cytosol] (R-MMU-50662) phospho-Bad [cytosol] (R-MMU-198335)	0.527	2
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.527	2
UniProt:Q9NQC7 CYLD	3	K48polyUb-K338, K530-CYLD [cytosol] (R-HSA-9818664) p-S418-CYLD [cytosol] (R-HSA-5212667) CYLD [cytosol] (R-HSA-741420)	0.527	2
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.527	2
UniProt:Q8WX92 NELFB	3	NELFB [nucleoplasm] (R-HSA-112427) NELFB [cytosol] (R-HSA-9603526) NELFB [mitochondrial outer membrane] (R-HSA-9603553)	0.527	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	3
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.527	2
UniProt:A0MZ66 SHTN1	1	KIAA1598 [cytosol] (R-HSA-443599)	0.527	2
UniProt:Q9P0N9 TBC1D7	1	TBC1D7 [cytosol] (R-HSA-8854154)	0.527	2
UniProt:Q0VF96 CGNL1			0.519	3
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.508	3
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.508	2
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.508	3
UniProt:Q7Z6J0 SH3RF1	1	SH3RF1 [cytosol] (R-HSA-5688968)	0.499	3
UniProt:P09622 DLD	8	I47T DLD [mitochondrial matrix] (R-HSA-9907707) D479V DLD [mitochondrial matrix] (R-HSA-9907708) G229C DLD [mitochondrial matrix] (R-HSA-9907709) R495G DLD [mitochondrial matrix] (R-HSA-9907710) E375K DLD [mitochondrial matrix] (R-HSA-9907711) I393T DLD [mitochondrial matrix] (R-HSA-9907713) M361V DLD [mitochondrial matrix] (R-HSA-9907714) DLD [mitochondrial matrix] (R-HSA-69978)	0.499	5
UniProt:Q15154 PCM1	1	PCM1 [cytosol] (R-HSA-380308)	0.499	3
UniProt:O00257-3 CBX4			0.499	2
UniProt:O43491 EPB41L2	1	EPB41L2 [cytosol] (R-HSA-6797548)	0.499	3
UniProt:P80192 M3K9			0.499	3
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581) DLST [mitochondrial matrix] (R-HSA-6792574)	0.499	4
UniProt:P49840 GSK3A	3	GSK3A [cytosol] (R-HSA-198326) p-S21-GSK3A [cytosol] (R-HSA-198352) p-Y279-GSK3A [cytosol] (R-HSA-9635490)	0.499	3
UniProt:P21796 VDAC1	7	PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991)	0.499	5
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.499	3
UniProt:Q96F86 EDC3	1	EDC3 [cytosol] (R-HSA-429997)	0.483	4
UniProt:Q8IVL1 NAV2			0.483	2
UniProt:Q9NR80 ARHGEF4	1	ARHGEF4 [cytosol] (R-HSA-2976635)	0.483	2
UniProt:O95696 BRD1	1	BRD1 [nucleoplasm] (R-HSA-3318450)	0.483	2
UniProt:Q5VT25 CDC42BPA	1	CDC42BPA [cytosol] (R-HSA-419871)	0.483	2
UniProt:Q8N350 CBARP			0.483	2
UniProt:Q76I76 SSH2			0.483	3
UniProt:O94915 FRYL			0.483	2
UniProt:P85299 PRR5	1	PRR5 [cytosol] (R-HSA-6795323)	0.483	3
UniProt:Q8TEH3 DENND1A	2	DENND1A [cytosol] (R-HSA-8877594) p-S536, S538 DENND1A [cytosol] (R-HSA-8933370)	0.483	3
UniProt:Q4KWH8 PLCH1	1	PLCH1 [plasma membrane] (R-HSA-2023859)	0.483	3
UniProt:Q5T0W9 FAM83B	1	FAM83B [cytosol] (R-HSA-9715184)	0.483	3
UniProt:Q12802 AKAP13	1	AKAP13 [cytosol] (R-HSA-2975983)	0.483	3
UniProt:Q86UU1 PHLB1			0.483	3
UniProt:Q6ZWE6 PKHM3			0.483	3
UniProt:P42345 MTOR	2	MTOR [nucleoplasm] (R-HSA-5083674) MTOR [cytosol] (R-HSA-165662)	0.483	3
UniProt:Q9H6H4 REEP4			0.483	3
UniProt:Q5SZL2 CE85L			0.483	2
UniProt:A7KAX9 ARHGAP32	1	ARHGAP32 [cytosol] (R-HSA-195134)	0.483	3
UniProt:Q8WWI1 LMO7	3	LMO7(1-1073)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713460) LMO7(1-1073)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713457) LMO7 [cytosol] (R-HSA-8862589)	0.483	2
UniProt:Q5VT97 SYDE2	1	SYDE2 [cytosol] (R-HSA-200589)	0.483	2
UniProt:O75592 MYCB2			0.483	3
UniProt:O00750 PIK3C2B	1	PIK3C2B [cytosol] (R-HSA-1604619)	0.483	3
UniProt:Q69YN4 VIR			0.483	2
UniProt:Q9ULJ3 ZBT21			0.483	2
UniProt:Q9UJF2 RASAL2	1	RASAL2 [cytosol] (R-HSA-5658224)	0.483	3
UniProt:P33176 KIF5B	3	KIF5B [cytosol] (R-HSA-265181) KIF5B(2-575)-p-7Y-ALK(1063-1620) fusion [cytosol] (R-HSA-9711937) KIF5B(2-575)-ALK(1063-1620) fusion [cytosol] (R-HSA-9711964)	0.483	2
UniProt:Q99550 MPP9			0.483	2
UniProt:Q6AWC2 WWC2			0.483	2
UniProt:Q9Y4F5 C170B			0.483	3
UniProt:Q6P1L5 F117B			0.483	3
UniProt:Q9UPV9 TRAK1	3	TRAK1 [cytosol] (R-HSA-5578870) TRAK1(1-325)-RAF1(279-648) fusion [cytosol] (R-HSA-6802474) TRAK1(1-325)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802554)	0.483	2
UniProt:Q9HCD6 TANC2			0.483	4
UniProt:Q9HAP2 MLXIP			0.483	3
UniProt:Q6UUV7 CRTC3	1	CRTC3 [nucleoplasm] (R-HSA-8931950)	0.483	3
UniProt:Q9UQ84 EXO1	1	EXO1 [nucleoplasm] (R-HSA-5357514)	0.483	2
UniProt:Q86X29 LSR	1	LSR [plasma membrane] (R-HSA-8933138)	0.483	3
UniProt:Q9Y6M7 SLC4A7	1	SLC4A7 [plasma membrane] (R-HSA-425552)	0.483	2
UniProt:Q8TF72 SHRM3			0.483	2
UniProt:Q53SF7 COBL1			0.483	2
UniProt:Q96PY6 NEK1	1	NEK1 [cytosol] (R-HSA-9861542)	0.483	3
UniProt:O15056 SYNJ2	1	SYNJ2 [cytosol] (R-HSA-1806193)	0.483	2
UniProt:O94964 MTCL2			0.483	3
UniProt:Q9BZF3 OSBPL6	1	OSBPL6 [cytosol] (R-HSA-8867534)	0.483	2
UniProt:Q96AY4 TTC28			0.483	2
UniProt:Q6WCQ1 MPRIP	2	MPRIP(2-1015)-RAF1(279-648) fusion [cytosol] (R-HSA-6802406) MPRIP(2-1015)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802540)	0.483	3
UniProt:Q70EL1 UBP54			0.483	2
UniProt:Q08AD1 CAMP2			0.483	3
UniProt:Q9HC77 CENPJ	2	CENPJ [cytosol] (R-HSA-380291) p-S589,S595-CENPJ [cytosol] (R-HSA-6801670)	0.483	2
UniProt:Q6N021 TET2	1	TET2 [nucleoplasm] (R-HSA-5221011)	0.483	2
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.483	2
UniProt:Q13009 TIAM1	2	p-Y829-TIAM1 [cytosol] (R-HSA-3928461) TIAM1 [cytosol] (R-HSA-195013)	0.483	2
UniProt:Q9NPI6 DCP1A	1	DCP1A [cytosol] (R-HSA-430043)	0.483	2
UniProt:O00429 DNM1L	2	DNM1L [mitochondrial outer membrane] (R-HSA-351942) DNM1L [cytosol] (R-HSA-351943)	0.483	4
UniProt:Q92538 GBF1	2	GBF1 [cytosol] (R-HSA-6807751) GBF1 [Golgi membrane] (R-HSA-199994)	0.483	3
UniProt:Q96RT1 ERBIN	1	ERBIN [plasma membrane] (R-HSA-1358718)	0.483	3
UniProt:Q96ST8 CEP89	1	CEP89 [cytosol] (R-HSA-5620930)	0.483	4
UniProt:Q86V48 LUZP1			0.471	3
UniProt:O35244	3	Prdx6 [extracellular region] (R-RNO-6806198) Prdx6 [azurophil granule lumen] (R-RNO-6798744) Prdx6 [cytosol] (R-RNO-3343670)	0.471	2
UniProt:Q8NEY1 NAV1			0.471	4
UniProt:Q8N4C8 MINK1	1	MINK1 [cytosol] (R-HSA-2532788)	0.471	3
UniProt:Q5VV41 ARHGEF16	1	ARHGEF16 [cytosol] (R-HSA-2976623)	0.471	4
UniProt:Q51451 Q51451			0.469	2
UniProt:P51957-2 NEK4			0.462	2
UniProt:P51957-1 NEK4			0.462	2
UniProt:Q76353 Q76353			0.462	2
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.462	3