Reactome | p-T,Y-MAPK8 [cytosol]

p-T,Y-MAPK8 [cytosol]

Stable Identifier

R-HSA-194371

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T,Y-JNK1, mitogen-activated protein kinase 8 (phosphorylated)

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Locations in the PathwayBrowser for interactor UniProt:O14733 MAP2K7

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External Reference Information

External Reference

UniProt:P45983 MAPK8

Gene Names

MAPK8, JNK1, PRKM8, SAPK1, SAPK1C

Chain

chain:1-427

Reference Genes

BioGPS Gene:5599 MAPK8

COSMIC (genes):MAPK8 MAPK8

CTD Gene:5599 MAPK8

dbSNP Gene:5599 MAPK8

ENSEMBL:ENSG00000107643 MAPK8

HGNC:6881 MAPK8

KEGG:hsa:5599 MAPK8

Monarch:5599 MAPK8

NCBI Gene:5599 MAPK8

OMIM:601158 MAPK8

UCSC:P45983 MAPK8

Reference Transcript

Participates

as a member of

as an input of

as an output of

Other forms of this molecule

p-T,Y-MAPK8 [nucleoplasm]

MAPK8 [cytosol]

Inferred To

phospho-p-T,Y-MAPK8 [cytosol] (Caenorhabditis elegans)

phospho-mapk8 [cytosol] (Danio rerio)

phospho-mapk8 [cytosol] (Xenopus tropicalis)

Homologues of p-T,Y-MAPK8 [cytosol] (Caenorhabditis elegans)

phospho-kgb-2 [cytosol] (Caenorhabditis elegans)

phospho-Mapk8 [cytosol] (Mus musculus)

phospho-Mapk8 [cytosol] (Rattus norvegicus)

phospho-MAPK8 [cytosol] (Bos taurus)

phospho-MAPK8 [cytosol] (Canis familiaris)

phospho-MAPK8 [cytosol] (Gallus gallus)

phospho-MAPK8 [cytosol] (Sus scrofa)

phospho-kgb-1 [cytosol] (Caenorhabditis elegans)

phospho-bsk [cytosol] (Drosophila melanogaster)

phospho-jnk-1 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-threonine at unknown position

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001310251.1, NP_001310250.1, XP_047281438.1, XP_047281440.1, NP_620637.1, NP_620634.1, NP_001310260.1, NP_001310257.1, NP_001310256.1, NP_001310255.1, NP_001310254.1, NP_001310231.1, NP_001310252.1, XP_047281436.1, XP_047281437.1, NP_001310253.1, XP_024303847.1, XP_024303848.1, NP_001310259.1, NP_001310258.1, XP_054222277.1, XP_054222278.1, XP_054222276.1, XP_054222275.1, XP_054222274.1, NP_001265476.1, NP_001265477.1, XP_054222279.1

ZINC - World Drugs

MK08_HUMAN

Guide to Pharmacology - Targets

1496

OpenTargets

ENSG00000107643

ENSEMBL

ENSP00000353483, ENSP00000363297, ENST00000374189, ENST00000374179, ENSP00000363304, ENST00000374176, ENSG00000107643, ENST00000395611, ENSP00000378974, ENST00000374182, ENSP00000363294, ENST00000360332, ENSP00000363291

ZINC - FDA approved

MK08_HUMAN

ZINC - Substances

MK08_HUMAN

ZINC - Biogenic

MK08_HUMAN

ZINC target

P45983

PRO

P45983

PDB

2G01, 4QTD, 3VUD, 3V3V, 8R5E, 8PTA, 6ZR5, 4L7F, 4YR8, 2GMX, 8PT9, 8PT8, 4AWI, 3VUI, 8X5M, 3VUL, 3VUG, 3VUM, 3VUH, 3VUK, 6F5E, 9FT9, 4IZY, 4G1W, 2NO3, 4UX9, 3O2M, 2XS0, 2XRW, 4HYU, 4E73, 5LW1, 4HYS, 2H96, 3O17, 1UKH, 1UKI, 3ELJ, 3PZE

ZINC - Investigational

MK08_HUMAN

HPA

ENSG00000107643-MAPK8

GeneCards

MAPK8

Pharos - Targets

P45983

ZINC - Predictions - Purchasable

MK08_HUMAN

HMDB Protein

HMDBP01536

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.854	5
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) MAPK9 [cytosol] (R-HSA-450355)	0.773	5
UniProt:Q9UQF2 JIP1			0.773	9
UniProt:P45985 MAP2K4	4	MAP2K4 [cytosol] (R-HSA-168107) p-S257,T261-MAP2K4 [cytosol] (R-HSA-168170) MAP2K4(1-?) [cytosol] (R-HSA-5211402) MAP2K4(?-399) [cytosol] (R-HSA-5211396)	0.759	4
UniProt:O43379 WDR62			0.725	4
UniProt:Q13202 DUSP8	2	DUSP8 [cytosol] (R-HSA-5675348) DUSP8 [nucleoplasm] (R-HSA-5675349)	0.659	3
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.623	6
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.553	2
UniProt:O14733-2 MAP2K7			0.544	3
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.536	2
UniProt:P29401 TKT	1	TKT [cytosol] (R-HSA-71321)	0.527	2
UniProt:P16104 H2AX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.524	3
UniProt:Q07817 BCL2L1	2	BCL2L1 [mitochondrial outer membrane] (R-HSA-114236) BCL2L1 [cytosol] (R-HSA-50771)	0.516	2
UniProt:Q9WVI9-1 MAPK8IP1			0.499	2
UniProt:Q8N122 RPTOR	3	p-S722,S792-RPTOR [cytosol] (R-HSA-3132767) RPTOR [cytosol] (R-HSA-3006727) RPTOR [nucleoplasm] (R-HSA-5083664)	0.499	6
UniProt:P56747 CLDN6	2	CLDN6 [plasma membrane] (R-HSA-419992) CLDN6 [cell junction] (R-HSA-421250)	0.488	3
UniProt:P60953 CDC42	3	CDC42 [plasma membrane] (R-HSA-449545) CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.483	2
UniProt:O14733 MAP2K7	4	p-S271,T275-MAP2K7 [cytosol] (R-HSA-450353) MAP2K7 [cytosol] (R-HSA-450276) MAP2K7(2-?) [cytosol] (R-HSA-5211389) MAP2K7(?-419) [cytosol] (R-HSA-5211401)	0.483	4

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