Reactome | VAV2 [cytosol]

VAV2 [cytosol]

Stable Identifier

R-HSA-195012

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
        
        PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
        
        VAV1,2,3 [cytosol] (Homo sapiens)
        
        VAV2 [cytosol] (Homo sapiens)
        
        VAV1,2,3 [cytosol] (Homo sapiens)
        
        VAV2 [cytosol] (Homo sapiens)
        
        VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK (Homo sapiens)
        
        IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
        
        PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
        
        VAV1,2,3 [cytosol] (Homo sapiens)
        
        VAV2 [cytosol] (Homo sapiens)
        
        PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
        
        VAV1,2,3 [cytosol] (Homo sapiens)
        
        VAV2 [cytosol] (Homo sapiens)
        
        p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)
        
        IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
        
        PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
        
        VAV1,2,3 [cytosol] (Homo sapiens)
        
        VAV2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P52735 VAV2

Gene Names

VAV2

Chain

chain:1-878

Reference Genes

BioGPS Gene:7410 VAV2

COSMIC (genes):VAV2 VAV2

CTD Gene:7410 VAV2

dbSNP Gene:7410 VAV2

ENSEMBL:ENSG00000160293 VAV2

HGNC:12658 VAV2

KEGG:hsa:7410 VAV2

Monarch:7410 VAV2

NCBI Gene:7410 VAV2

OMIM:600428 VAV2

UCSC:P52735 VAV2

Reference Transcript

Participates

as a member of

as a candidate of

as an input of

Phosphorylation of VAV2 (Homo sapiens)

Other forms of this molecule

p-Y172-VAV2 [cytosol]

Inferred To

Vav2 [cytosol] (Mus musculus)

Vav2 [cytosol] (Rattus norvegicus)

vav-1 [cytosol] (Caenorhabditis elegans)

VAV2 [cytosol] (Bos taurus)

VAV2 [cytosol] (Canis familiaris)

VAV2 [cytosol] (Gallus gallus)

VAV2 [cytosol] (Sus scrofa)

Vav [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001127870.1, NP_003362.2, XP_005272270.1

ENSEMBL

ENSP00000360916, ENSP00000360917, ENST00000371850, ENST00000406606, ENST00000371851, ENSG00000160293, ENSP00000385362

OpenTargets

ENSG00000160293

GeneCards

VAV2

HPA

ENSG00000160293-VAV2

PRO

P52735

Pharos - Targets

P52735

GlyGen

P52735

HMDB Protein

HMDBP10954

PDB

2DM1, 2LNX, 7WFY, 7RNV, 2LNW, 2DLZ, 4ROJ

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78314 3BP2			0.67	4
UniProt:Q9H3M7 TXNIP	2	TXNIP [cytosol] (R-HSA-1250246) TXNIP [nucleoplasm] (R-HSA-9617747)	0.558	2
UniProt:Q8WZ42 TTN	2	TTN [cytosol] (R-HSA-350726) TTN [extracellular region] (R-HSA-350729)	0.553	2
UniProt:O75674 TM1L1			0.508	2
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.499	2

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