Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PLEKHG2 [cytosol]
Stable Identifier
R-HSA-195043
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Plekhg-2/Clg
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
PLEKHG2 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
PLEKHG2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
PLEKHG2 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
PLEKHG2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H7P9 PLEKHG2
Gene Names
PLEKHG2
Chain
chain:1-1386
Reference Genes
BioGPS Gene:64857 PLEKHG2
COSMIC (genes):PLEKHG2 PLEKHG2
CTD Gene:64857 PLEKHG2
dbSNP Gene:64857 PLEKHG2
ENSEMBL:ENSG00000090924 PLEKHG2
HGNC:29515 PLEKHG2
KEGG:hsa:64857 PLEKHG2
Monarch:64857 PLEKHG2
NCBI Gene:64857 PLEKHG2
OMIM:611893 PLEKHG2
UCSC:Q9H7P9 PLEKHG2
Reference Transcript
RefSeq:NM_022835.2 PLEKHG2
RefSeq:XM_005259163.2 PLEKHG2
Other Identifiers
11715169_at
1558407_PM_at
1558407_at
16862001
225979_PM_at
225979_at
233986_PM_s_at
233986_s_at
3832991
3832993
3832994
3832995
3832996
3832997
3832998
3832999
3833000
3833001
3833002
3833003
3833004
3833005
3833006
3833007
3833008
3833009
3833010
3833011
3833012
3833013
3833014
3833015
3833016
3833017
3833018
3833019
3833020
3833021
3833022
3833023
3833024
3833025
3833026
3833027
3833028
3833029
3833030
42042_at
56962_at
64857
8028656
A_14_P105354
A_23_P323563
A_33_P3309175
GE88703
GO:0005085
GO:0005515
GO:0005829
GO:0030833
GO:0031267
GO:0098772
HMNXSV003036193
Hs.111217.0.S1_3p_a_at
Hs2.346312.1.A1_3p_at
ILMN_1657836
PH_hs_0006107
TC19000545.hg
Participates
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
as a member of
GEFs [cytosol] (Homo sapiens)
Inferred To
plekhg2 [cytosol]
(Xenopus tropicalis)
uig-1 [cytosol]
(Caenorhabditis elegans)
Plekhg2 [cytosol]
(Mus musculus)
Plekhg2 [cytosol]
(Rattus norvegicus)
GEFmeso [cytosol]
(Drosophila melanogaster)
PLEKHG2 [cytosol]
(Bos taurus)
PLEKHG2 [cytosol]
(Canis familiaris)
PLEKHG2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_073746.2
,
XP_005259220.1
ENSEMBL
ENST00000409797
,
ENSP00000386492
,
ENSP00000392906
,
ENST00000425673
OpenTargets
ENSG00000090924
HPA
ENSG00000090924-PLEKHG2
PRO
Q9H7P9
Pharos - Targets
Q9H7P9
GlyGen
Q9H7P9
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text