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What is Reactome ?
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VAV1 [cytosol]
Stable Identifier
R-HSA-195066
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK (Homo sapiens)
IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-6Y-SYK phosphorylates VAV1,2,3 (Homo sapiens)
IgG:Leishmania surface:FCGR3Ap-CD3 dimers:p-6Y-SYK:VAV1,2,3:PI(3,4,5)P3 [plasma membrane] (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
BTK binds BTK inhibitors (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
PIP2 binds inhibiting VAV (Homo sapiens)
VAV family [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
VAV family:PIP2 [plasma membrane] (Homo sapiens)
VAV family [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
VAV1 is a GEF for Rho/Rac family GTPases (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
VAV family:PIP2 [plasma membrane] (Homo sapiens)
VAV family [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-SLP-76 binds VAV (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-SLP-76:VAV [cytosol] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-Y348-SYK binds VAV family (Homo sapiens)
VAV family [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-Y348-SYK:VAV family [cytosol] (Homo sapiens)
VAV family [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-Y348-SYK phosphorylates VAV family (Homo sapiens)
p-Y348-SYK:VAV family [cytosol] (Homo sapiens)
VAV family [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
CD28 co-stimulation (Homo sapiens)
CD28 dependent Vav1 pathway (Homo sapiens)
Activation of Vav1 (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Translocation of Vav1 to CD28 (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BTK autophosphorylates (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
BTK binds BTK inhibitors (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
BTK:BTK inhibitors [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-SYK and LYN phosphorylate BTK (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
LYN, p-SYK [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
IL3 stimulation induces Vav binding to Tec kinase (Homo sapiens)
TEC:VAV1 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL binds VAV (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Autophosphorylation of BTK/ITK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Phosphorylation and activation of VAV (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Recruitment of VAV to p-SLP-76 (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Phosphorylation of VAV (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Recruitment of VAV1 to p-6Y-SYK (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates RAS (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:VAV1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Homo sapiens)
GRB2-1:VAV1 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
GRB2-1:VAV1 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:VAV1 [plasma membrane] (Homo sapiens)
GRB2-1:VAV1 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Phosphorylation and activation of VAV1 (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
PI(3,4,5)P3 binds VAV1,2,3 (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Src kinases phosphorylate VAV (Homo sapiens)
PIP3:VAV1,2,3 [plasma membrane] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
VAV exchanges GTP for GDP on RAC1, activating it (Homo sapiens)
VAV family [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 GEFs activate RAC2 (Homo sapiens)
RAC2 GEFs [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG GEFs activate RHOG (Homo sapiens)
RHOG GEFs [cytosol] (Homo sapiens)
VAV1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15498 VAV1
Gene Names
VAV1, VAV
Chain
chain:1-845
Reference Genes
BioGPS Gene:7409 VAV1
COSMIC (genes):VAV1 VAV1
CTD Gene:7409 VAV1
dbSNP Gene:7409 VAV1
ENSEMBL:ENSG00000141968 VAV1
ENSEMBL_homo_sapiens_GENE:ENSG00000141968.8 VAV1
HGNC:12657 VAV1
KEGG Gene (Homo sapiens):7409 VAV1
Monarch:7409 VAV1
NCBI Gene:7409 VAV1
OMIM:164875 VAV1
UCSC:P15498 VAV1
Reference Transcript
RefSeq:NM_001258207.1 VAV1
RefSeq:NM_005428.3 VAV1
Other Identifiers
11741047_a_at
11763606_a_at
16857490
1919_at
206219_PM_s_at
206219_s_at
34481_at
3818548
3818549
3818558
3818559
3818560
3818562
3818563
3818564
3818565
3818566
3818568
3818569
3818571
3818572
3818573
3818575
3818576
3818577
3818579
3818581
3818582
3818584
3818587
3818590
3818591
3818592
3818593
3818594
3818595
7409
8025076
A_14_P134945
A_23_P38959
GO:0001784
GO:0002376
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006909
GO:0006955
GO:0007155
GO:0007166
GO:0007186
GO:0007229
GO:0008361
GO:0016192
GO:0016477
GO:0023052
GO:0030154
GO:0030168
GO:0030217
GO:0030593
GO:0031295
GO:0035556
GO:0038095
GO:0038096
GO:0042060
GO:0042110
GO:0043087
GO:0045785
GO:0045954
GO:0046872
GO:0048010
GO:0048856
GO:0048870
GO:0051056
GO:0071466
GO:0072593
GO:0098542
GO:0098772
GO:0140031
HMNXSV003050730
ILMN_1717334
PH_hs_0006359
TC19000119.hg
X16316_at
g7108366_3p_a_at
Participates
as a component of
GRB2-1:VAV1 [cytosol] (Homo sapiens)
TEC:VAV1 [cytosol] (Homo sapiens)
p(Y700,731,774)-CBL:VAV1 [cytosol] (Homo sapiens)
Syk:VAV1 [cytosol] (Homo sapiens)
VAV1:PIP3:CD28:GRB2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RAC2 GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
RHOG GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
VAV family [cytosol] (Homo sapiens)
VAV1,2,3 [cytosol] (Homo sapiens)
as an input of
Phosphorylation and activation of VAV1 (Homo sapiens)
IL3 stimulation induces Vav binding to Tec kinase (Homo sapiens)
CBL binds VAV (Homo sapiens)
Pig Syk binds human Vav1 (Sus scrofa)
Translocation of Vav1 to CD28 (Homo sapiens)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
Other forms of this molecule
p-Y-VAV1 [cytosol]
VAV1 [plasma membrane]
p-Y174-VAV1 [cytosol]
p-Y142,Y160,Y174-VAV1 [plasma membrane]
Inferred To
Ghost homologue of VAV1 [cytosol]
(Gallus gallus)
Vav1 [cytosol]
(Mus musculus)
Vav1 [cytosol]
(Rattus norvegicus)
vav-1 [cytosol]
(Caenorhabditis elegans)
VAV1 [cytosol]
(Bos taurus)
VAV1 [cytosol]
(Canis familiaris)
VAV1 [cytosol]
(Sus scrofa)
vav1 [cytosol]
(Xenopus tropicalis)
Vav [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_005419.2
,
NP_001245136.1
OpenTargets
ENSG00000141968
GeneCards
P15498
HPA
ENSG00000141968-VAV1
ZINC - Substances
VAV_HUMAN
ZINC target
P15498
Ensembl
ENST00000596764
,
ENSP00000469450
,
ENST00000602142
,
ENSP00000472929
,
ENSG00000141968
PRO
P15498
Pharos - Targets
P15498
ZINC - Predictions - Purchasable
VAV_HUMAN
HMDB Protein
HMDBP10969
PDB
6NEW
,
6NF1
,
6NFA
,
2ROR
,
3KY9
,
3BJI
,
2MC1
,
2CRH
,
2LCT
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P78314 3BP2
0.788
8
UniProt:Q13094 LCP2
2
p-Y113,128,145-LCP2 [cytosol]
(R-HSA-202175)
LCP2 [cytosol]
(R-HSA-202306)
0.758
9
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.665
3
UniProt:P00519 ABL1
6
p-Y393-ABL1 [cytosol]
(R-HSA-9865161)
p-Y226,Y393-ABL1 [nucleoplasm]
(R-HSA-8985251)
ABL1 [cytosol]
(R-HSA-375987)
p-Y226,Y393-ABL1 [cytosol]
(R-HSA-8942610)
ABL1 [nucleoplasm]
(R-HSA-5686579)
p-S456-ABL1 [nucleoplasm]
(R-HSA-5686576)
0.602
5
UniProt:Q8N720 ZNF655
1
ZNF655 [nucleoplasm]
(R-HSA-2127575)
0.581
5
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.558
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q6UWP8 SBSN
1
SBSN [secretory granule lumen]
(R-HSA-9839544)
0.527
2
UniProt:Q69YQ0 CYTSA
0.527
2
UniProt:Q8NEX9 SDR9C7
1
SDR9C7 [endoplasmic reticulum membrane]
(R-HSA-4084690)
0.527
2
UniProt:Q6P4A8 PLBD1
1
PLBD1 [cytosol]
(R-HSA-1524034)
0.527
2
UniProt:Q8IW75 SPA12
0.527
2
UniProt:Q15517 CDSN
2
CDSN [cornified envelope]
(R-HSA-8847707)
CDSN [plasma membrane]
(R-HSA-6814395)
0.527
2
UniProt:Q562R1 ACTBL
0.527
2
UniProt:P62736 ACTA2
1
ACTA2 [cytosol]
(R-HSA-445792)
0.527
2
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.524
3
UniProt:P08487 PLCG1
0.471
4
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