Reactome | ARHGEF2 [cytosol]

ARHGEF2 [cytosol]

Stable Identifier

R-HSA-195101

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Gef-h1, Arhgef2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92974 ARHGEF2

Gene Names

ARHGEF2, KIAA0651, LFP40

Chain

chain:1-986

Reference Genes

BioGPS Gene:9181 ARHGEF2

COSMIC (genes):ARHGEF2 ARHGEF2

CTD Gene:9181 ARHGEF2

dbSNP Gene:9181 ARHGEF2

ENSEMBL:ENSG00000116584 ARHGEF2

HGNC:682 ARHGEF2

KEGG:hsa:9181 ARHGEF2

Monarch:9181 ARHGEF2

NCBI Gene:9181 ARHGEF2

OMIM:607560 ARHGEF2

UCSC:Q92974 ARHGEF2

Reference Transcript

Other Identifiers

11745549_a_at

11749038_a_at

11754291_s_at

1554783_PM_s_at

1554783_s_at

16694361

207629_PM_s_at

207629_s_at

209435_PM_s_at

209435_s_at

235595_PM_at

235595_at

2437800

2437802

2437803

2437804

2437805

2437806

2437807

2437808

2437809

2437810

2437811

2437812

2437813

2437814

2437815

2437816

2437818

2437821

2437822

2437824

2437825

2437826

2437827

2437828

2437829

2437830

2437831

2437833

2437834

2437835

2437836

2437837

2437838

2437839

2437840

2437841

2437842

2437843

2437844

2437851

2437852

2437853

2437854

2437855

2437856

2437857

2437858

2437859

2437860

2437861

2437862

2437864

2437866

2437867

2437868

2437870

40099_at

40101_g_at

70705_at

75496_at

7920877

9181

A_21_P0001180

A_23_P51699

A_33_P3327058

GE53362

GE833898

GO:0000902

GO:0002376

GO:0005085

GO:0005515

GO:0005737

GO:0005794

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0005923

GO:0005925

GO:0006355

GO:0006886

GO:0007015

GO:0007026

GO:0007399

GO:0008017

GO:0008092

GO:0008270

GO:0030154

GO:0031267

GO:0031410

GO:0031982

GO:0032587

GO:0032755

GO:0032760

GO:0032991

GO:0035023

GO:0042127

GO:0042995

GO:0043226

GO:0045087

GO:0045666

GO:0045944

GO:0046872

GO:0048856

GO:0050731

GO:0051056

GO:0051092

GO:0051301

GO:0055059

GO:0060546

GO:0071225

GO:0071356

GO:0071474

GO:0098542

GO:0098772

GO:1902042

GO:1902219

GO:2001224

HMNXSV003007185

HMNXSV003010474

HMNXSV003021242

HMNXSV003044520

Hs.105739.0.A1_3p_at

Hs2.337774.2.S1_3p_s_at

ILMN_1703477

PH_hs_0016573

TC01003328.hg

TC01005853.hg

U72206_at

g12653008_3p_s_at

g4758671_3p_s_at

p472

p473

Participates

as a member of

Inferred To

gxcN [cytosol] (Dictyostelium discoideum)

ARHGEF2 [cytosol] (Bos taurus)

ARHGEF2 [cytosol] (Canis familiaris)

ARHGEF2 [cytosol] (Sus scrofa)

rhgf-3 [cytosol] (Caenorhabditis elegans)

arhgef2 [cytosol] (Xenopus tropicalis)

Arhgef2 [cytosol] (Mus musculus)

Arhgef2 [cytosol] (Rattus norvegicus)

cyst [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001155856.1, NP_001155855.1, NP_004714.2

OpenTargets

ENSG00000116584

ENSEMBL

ENSP00000314787, ENSP00000315325, ENSP00000354837, ENST00000313695, ENST00000361247, ENST00000313667

HPA

ENSG00000116584-ARHGEF2

PRO

Q92974

Pharos - Targets

Q92974

GlyGen

Q92974

HMDB Protein

HMDBP08310

PDB

7G8R, 7G8P, 7G8S, 7G99, 7G9A, 7G8Z, 7G9C, 7G8Q, 7G82, 7G80, 7G8H, 7G8J, 7G8I, 7G88, 7G9G, 7G9E, 7G8V, 7G8C, 7G8W, 7G8T, 7G84, 7G86, 7G8U, 7G8O, 7G8L, 7G8F, 7G8D, 7G9I, 7G93, 7G91, 7G8X, 7G94, 7G9D, 7G8Y, 7G9B, 7G92, 7G83, 7G81, 5EFX, 7G8K, 7G8B, 7G97, 7G89, 7G95, 7G9H, 7G9F, 7G8A, 7G8N, 7G85, 7G87, 7G98, 7G96, 7G90, 7G8M, 7G8G, 7G8E, 8BNT, 7G9J

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.859	7
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.742	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.671	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.649	6
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.564	2
UniProt:Q15173 PPP2R5B	2	p-S368-PPP2R5B [cytosol] (R-HSA-6811453) PPP2R5B [cytosol] (R-HSA-535469)	0.527	2
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.527	2
UniProt:O43524 FOXO3	11	FOXO3 [nucleoplasm] (R-HSA-199305) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) FOXO3 [cytosol] (R-HSA-5687032) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	4

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