Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ARHGAP35 [cytosol]
Stable Identifier
R-HSA-195118
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GRLF1/p190-A variant 1, p190RhoGAP
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D mediated inhibition of cell attachment and migration (Homo sapiens)
Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
p190RhoGAP binds Plexin-B1 (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
PTK6 binds ARHGAP35 (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
p-Y342-PTK6:ARHGAP35 [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
PTK6 phosphorylates ARHGAP35 (Homo sapiens)
p-Y342-PTK6:ARHGAP35 [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GAPs stimulate CDC42 GTPase activity (Homo sapiens)
CDC42 GAPs [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GAPs stimulate RAC1 GTPase activity (Homo sapiens)
RAC1 GAPs [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 GAPs stimulate RAC2 GTPase activity (Homo sapiens)
RAC2 GAPs [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 GAPs stimulate RAC3 GTPase activity (Homo sapiens)
RAC3 GAPs [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GAPs stimulate RHOA GTPase activity (Homo sapiens)
RHOA GAPs [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GAPs stimulate RHOB GTPase activity (Homo sapiens)
RHOB GAPs [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GAPs stimulate RHOC GTPase activity (Homo sapiens)
RHOC GAPs [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RHOD GTPase cycle (Homo sapiens)
RHOD GAPs stimulate RHOD GTPase activity (Homo sapiens)
RHOD GAPs [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG GAPs stimulate RHOG GTPase activity (Homo sapiens)
RHOG GAPs [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RHOJ GTPase cycle (Homo sapiens)
RHOJ GAPs stimulate RHOJ GTPase activity (Homo sapiens)
RHOJ GAPs [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RHOQ GTPase cycle (Homo sapiens)
RHOQ GAPs stimulate RHOQ GTPase activity (Homo sapiens)
RHOQ GAPs [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RND1 GTPase cycle (Homo sapiens)
RND1 binds effectors (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RND1:GTP:RND1 effectors [plasma membrane] (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RND2 GTPase cycle (Homo sapiens)
RND2 binds effectors (Homo sapiens)
RND2 effectors [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RND2:GTP:RND2 effectors [plasma membrane] (Homo sapiens)
RND2 effectors [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RND3 GTPase cycle (Homo sapiens)
RND3 binds effectors (Homo sapiens)
RND3 effectors [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
RND3:GTP:RND3 effectors [plasma membrane] (Homo sapiens)
RND3 effectors [cytosol] (Homo sapiens)
ARHGAP35 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NRY4 ARHGAP35
Gene Names
ARHGAP35, GRF1, GRLF1, KIAA1722, P190A, p190ARHOGAP
Chain
chain:1-1499
Reference Genes
BioGPS Gene:2909 ARHGAP35
COSMIC (genes):ARHGAP35 ARHGAP35
CTD Gene:2909 ARHGAP35
dbSNP Gene:2909 ARHGAP35
ENSEMBL:ENSG00000160007 ARHGAP35
HGNC:4591 ARHGAP35
KEGG:hsa:2909 ARHGAP35
Monarch:2909 ARHGAP35
NCBI Gene:2909 ARHGAP35
OMIM:605277 ARHGAP35
UCSC:Q9NRY4 ARHGAP35
Reference Transcript
RefSeq:XM_017026714.1 ARHGAP35
RefSeq:NM_004491.4 ARHGAP35
Other Identifiers
11725420_at
11725421_a_at
11725422_s_at
11746448_a_at
11748374_a_at
1565881_3p_at
1565881_PM_at
1565881_at
16863521
16863534
202044_PM_at
202044_at
202045_PM_s_at
202045_s_at
202046_PM_s_at
202046_s_at
229394_3p_s_at
229394_PM_s_at
229394_s_at
2909
34724_at
34725_at
3836980
3837002
3837003
3837004
3837005
3837006
3837007
3837011
3837017
3837018
3837019
3837034
3837035
3837036
3837042
3837043
3837044
3837045
3837046
3837047
3837048
3837049
3837050
3837051
3837052
3837053
3837054
3837055
3837056
3837057
3837058
3837059
3837060
3837061
3837062
3837063
3837064
3837069
3837071
3837073
3837075
53559_at
8029856
A_14_P128858
A_23_P39137
A_24_P36299
A_24_P44845
A_33_P3367481
GE58056
GO:0001843
GO:0003013
GO:0003677
GO:0003824
GO:0003924
GO:0005096
GO:0005525
GO:0005543
GO:0005634
GO:0005737
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0007010
GO:0007163
GO:0007165
GO:0007266
GO:0007411
GO:0007413
GO:0008064
GO:0008289
GO:0008360
GO:0008361
GO:0010976
GO:0015629
GO:0016477
GO:0016787
GO:0021955
GO:0030879
GO:0030900
GO:0030950
GO:0032956
GO:0035024
GO:0036064
GO:0042995
GO:0043010
GO:0043116
GO:0043226
GO:0044319
GO:0045724
GO:0048856
GO:0048870
GO:0050770
GO:0051056
GO:0097485
GO:0098772
HMNXSV003049975
Hs.102548.0.A2_3p_at
Hs.102548.0.A3_3p_a_at
Hs.102548.2.A1_3p_a_at
Hs.102548.2.A1_3p_at
Hs2.378706.1.S1_3p_at
Hs2.378706.1.S1_3p_x_at
ILMN_1658145
ILMN_1687362
ILMN_1696845
M73077_at
PH_hs_0005686
TC19000669.hg
TC19000670.hg
g4758481_3p_a_at
Participates
as a candidate of
RND2 effectors [cytosol] (Homo sapiens)
RHOA GAPs [cytosol] (Homo sapiens)
RND3 effectors [cytosol] (Homo sapiens)
RHOC GAPs [cytosol] (Homo sapiens)
RHOQ GAPs [cytosol] (Homo sapiens)
CDC42 GAPs [cytosol] (Homo sapiens)
RAC1 GAPs [cytosol] (Homo sapiens)
RHOB GAPs [cytosol] (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
as a member of
RAC2 GAPs [cytosol] (Homo sapiens)
RHOD GAPs [cytosol] (Homo sapiens)
RHOG GAPs [cytosol] (Homo sapiens)
RHOJ GAPs [cytosol] (Homo sapiens)
RAC3 GAPs [cytosol] (Homo sapiens)
as a component of
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane] (Homo sapiens)
p-Y342-PTK6:ARHGAP35 [cytosol] (Homo sapiens)
as an input of
p190RhoGAP binds Plexin-B1 (Homo sapiens)
PTK6 binds ARHGAP35 (Homo sapiens)
Other forms of this molecule
p-Y1105-ARHGAP35 [cytosol]
Inferred To
RhoGAPp190 [cytosol]
(Drosophila melanogaster)
arhgap35 [cytosol]
(Xenopus tropicalis)
arhgap35a [cytosol]
(Danio rerio)
ARHGAP35 [cytosol]
(Bos taurus)
ARHGAP35 [cytosol]
(Canis familiaris)
ARHGAP35 [cytosol]
(Gallus gallus)
ARHGAP35 [cytosol]
(Mus musculus)
ARHGAP35 [cytosol]
(Rattus norvegicus)
ARHGAP35 [cytosol]
(Sus scrofa)
rga-5 [cytosol]
(Caenorhabditis elegans)
Cross References
ENSEMBL
ENST00000672722
,
ENSG00000160007
,
ENSP00000500409
OpenTargets
ENSG00000160007
GeneCards
ARHGAP35
HPA
ENSG00000160007-ARHGAP35
PRO
Q9NRY4
Pharos - Targets
Q9NRY4
PDB
3FK2
,
8DGQ
,
6WAY
,
6PXC
,
2K85
,
3C5H
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05120 SERPINB2
2
SERPINB2 [plasma membrane]
(R-HSA-159004)
SERPINB2 [extracellular region]
(R-HSA-158997)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text