Reactome | RACGAP1 [cytosol]

RACGAP1 [cytosol]

Stable Identifier

R-HSA-195122

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MgcRacGAP

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Retrograde COPI vesicles bind kinesin and microtubules (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        RACGAP1 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        RACGAP1 [cytosol] (Homo sapiens)
        
        Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        RACGAP1 [cytosol] (Homo sapiens)
        
        RAB1:GTP:coatomer:p24 dimers:SEC22B:kinesins:microtubules [transport vesicle] (Homo sapiens)
        
        Kinesins:microtubule [cytosol] (Homo sapiens)
        
        Kinesins [cytosol] (Homo sapiens)
        
        Centralspindlin [cytosol] (Homo sapiens)
        
        RACGAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H0H5 RACGAP1

Gene Names

RACGAP1, KIAA1478, MGCRACGAP

Chain

chain:1-632

Reference Genes

BioGPS Gene:29127 RACGAP1

COSMIC (genes):RACGAP1 RACGAP1

CTD Gene:29127 RACGAP1

dbSNP Gene:29127 RACGAP1

ENSEMBL:ENSG00000161800 RACGAP1

HGNC:9804 RACGAP1

Monarch:29127 RACGAP1

NCBI Gene:29127 RACGAP1

OMIM:604980 RACGAP1

UCSC:Q9H0H5 RACGAP1

Reference Transcript

Other Identifiers

11723583_a_at

11723584_x_at

11758149_s_at

222077_PM_s_at

222077_s_at

29127

3169272

3451963

3451968

3451969

3451974

3454224

3454227

3454228

3454229

3454230

3454231

3454232

3454233

3454234

3454235

3454236

3454237

3454239

3454240

3454241

3454242

3454243

3454244

3454245

3454246

3454247

3454249

3454250

3454253

3454255

3454257

3454258

3454259

3454261

3454266

50271_at

70829_at

7963157

A_23_P65110

GO:0000281

GO:0000910

GO:0000915

GO:0001669

GO:0005096

GO:0005515

GO:0005547

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005886

GO:0006811

GO:0007010

GO:0007165

GO:0007266

GO:0007283

GO:0007405

GO:0008017

GO:0008092

GO:0008272

GO:0008289

GO:0009898

GO:0019901

GO:0022414

GO:0030154

GO:0030218

GO:0030496

GO:0030674

GO:0031410

GO:0032154

GO:0032467

GO:0043014

GO:0043015

GO:0043226

GO:0045995

GO:0046872

GO:0048487

GO:0051056

GO:0051233

GO:0051256

GO:0051301

GO:0051988

GO:0060090

GO:0070062

GO:0072686

GO:0090543

GO:0097149

GO:0098772

HMNXSV003013644

HMNXSV003016188

Hs.23900.1.S1_3p_a_at

ILMN_1702140

ILMN_1867373

ILMN_2077550

PH_hs_0031085

TC12001489.hg

Participates

as a candidate of

as a member of

as a component of

Centralspindlin [cytosol] (Homo sapiens)

as an input of

Kinesin-6 and RACGAP1 form the heterotetrameric complex centralspindlin (Homo sapiens)

Inferred To

RACGAP1 [cytosol] (Bos taurus)

RACGAP1 [cytosol] (Canis familiaris)

RACGAP1 [cytosol] (Gallus gallus)

RACGAP1 [cytosol] (Sus scrofa)

racgap1 [cytosol] (Danio rerio)

racgap1 [cytosol] (Xenopus tropicalis)

cyk-4 [cytosol] (Caenorhabditis elegans)

Racgap1 [cytosol] (Mus musculus)

Racgap1 [cytosol] (Rattus norvegicus)

tum [cytosol] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000161800

ENSEMBL

ENSP00000404190, ENSP00000449374, ENST00000312377, ENSP00000404808, ENSP00000449370, ENST00000547905, ENST00000427314, ENST00000454520, ENSP00000309871, ENST00000551016

HPA

ENSG00000161800-RACGAP1

PRO

Q9H0H5

Pharos - Targets

Q9H0H5

GlyGen

Q9H0H5

HMDB Protein

HMDBP10972

PDB

2OVJ, 3W6R, 5C2K, 5C2J, 4B6D, 3WPS, 3WPQ

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q02241 KIF23	3	KIF23 [cytosol] (R-HSA-1015863) p-S911,S912-KIF23 [nucleoplasm] (R-HSA-156695) KIF23 [nucleoplasm] (R-HSA-156709)	0.922	16
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.897	8
UniProt:Q9H8V3 ECT2	1	ECT2 [cytosol] (R-HSA-195036)	0.88	15
UniProt:Q8NEM2 SHCBP			0.788	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.758	4
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.71	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.706	4
UniProt:O75154 RAB11FIP3	1	RAB11FIP3 [cytosol] (R-HSA-5623397)	0.65	7
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.643	3
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.643	3
UniProt:Q16537 PPP2R5E	1	PPP2R5E [cytosol] (R-HSA-1638770)	0.593	5
UniProt:Q9JLQ0 Cd2ap	1	CD2AP_MOUSE [cytosol] (R-MMU-451711)	0.564	2
UniProt:E9Q5G3	3	KIF23 [cytosol] (R-MMU-1015863) phospho-p-S911,S912-KIF23 [nucleoplasm] (R-MMU-156695) KIF23 [nucleoplasm] (R-MMU-156709)	0.564	2
UniProt:Q9Z179 SHCBP			0.564	2
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q9Y228 T3JAM			0.556	3
UniProt:Q00526 CDK3			0.556	3
UniProt:Q9UBU8 MORF4L1	1	MORF4L1 [nucleoplasm] (R-HSA-3321982)	0.556	3
UniProt:O14757 CHEK1	3	p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838) CHEK1 [nucleoplasm] (R-HSA-113826) CHEK1 [cytosol] (R-HSA-205285)	0.527	2
UniProt:Q8NCA5 FA98A			0.527	2
UniProt:Q9P2G9 KLHL8			0.527	2
UniProt:Q02241-2 KIF23			0.527	2
UniProt:Q96RN1 S26A8			0.508	2
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.499	2