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SRGAP2 [cytosol]
Stable Identifier
R-HSA-195131
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SrGAP2, ARHGAP34
Icon
Locations in the PathwayBrowser for interactor UniProt:Q8N7C3 TRIMM
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)
SRGAP2 [cytosol] (Homo sapiens)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)
SRGAP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75044 SRGAP2
Gene Names
SRGAP2, ARHGAP34, FNBP2, KIAA0456, SRGAP2A
Chain
chain:1-1071
Reference Genes
BioGPS Gene:23380 SRGAP2
COSMIC (genes):SRGAP2 SRGAP2
CTD Gene:23380 SRGAP2
dbSNP Gene:23380 SRGAP2
ENSEMBL:ENSG00000266028 SRGAP2
HGNC:19751 SRGAP2
KEGG:hsa:23380 SRGAP2
Monarch:23380 SRGAP2
NCBI Gene:23380 SRGAP2
OMIM:606524 SRGAP2
UCSC:O75044 SRGAP2
Reference Transcript
RefSeq:NM_001170637.3 SRGAP2
RefSeq:NM_015326.4 SRGAP2
RefSeq:XM_005277510.2 SRGAP2
Other Identifiers
11719438_at
11719439_at
11719440_at
11722940_a_at
11760394_a_at
1568955_PM_at
1568955_at
1568957_PM_x_at
1568957_x_at
16669568
16676562
16691721
16698618
17125876
213329_PM_at
213329_at
227649_PM_s_at
227649_s_at
23380
2376704
2376705
2376715
2376717
2376734
2376735
2376737
2376739
2376741
2376743
2376745
2376747
2376751
2376753
2376755
2376757
2376759
2376764
2376766
2376768
2376770
2376774
2376776
2376778
2376780
2376782
2376784
2376786
2376788
2376790
2376792
2376794
2376796
2431725
2431726
2431727
2431728
2431730
2431731
2431732
2431734
2431735
2431736
2431737
2431741
2431742
2431750
2431755
36069_at
4054379
4054382
4054384
4054385
50170_s_at
64479_at
76002_at
7904469
7904482
7909175
ADDON001107.hg
A_23_P200829
A_24_P357869
A_32_P50123
A_33_P3213772
A_33_P3246022
A_33_P3274009
A_33_P3275255
A_33_P3369128
A_33_P3372705
A_33_P3441576
GE53197
GE55644
GE87888
GO:0003363
GO:0005096
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0007010
GO:0007155
GO:0007165
GO:0007399
GO:0014069
GO:0021816
GO:0030027
GO:0030334
GO:0030336
GO:0031267
GO:0031410
GO:0034330
GO:0034446
GO:0042802
GO:0042803
GO:0042995
GO:0043197
GO:0043226
GO:0043547
GO:0044327
GO:0045202
GO:0045211
GO:0045335
GO:0046847
GO:0048812
GO:0048856
GO:0051014
GO:0051056
GO:0051963
GO:0060996
GO:0098772
GO:0098978
GO:1904861
GO:1904862
GO:2001223
HMNXSV003005080
HMNXSV003006393
HMNXSV003013505
HMNXSV003026311
HMNXSV003028241
HMNXSV003029668
HMNXSV003057573
Hs.306413.0.A1_3p_a_at
Hs.5003.0.A1_3p_at
Hs2.397546.1.S1_3p_s_at
ILMN_1688294
ILMN_1753692
ILMN_1755910
ILMN_1759549
ILMN_1780308
ILMN_1797451
ILMN_2261379
ILMN_2348448
PH_hs_0000513
PH_hs_0034516
PH_hs_0036061
TC01001050.hg
TC01001074.hg
TC01001721.hg
TC01003055.hg
TC01003757.hg
TC01004674.hg
TC01004687.hg
p28963
Participates
as a candidate of
RHOQ GAPs [cytosol] (Homo sapiens)
CDC42 GAPs [cytosol] (Homo sapiens)
RHOF GAPs [cytosol] (Homo sapiens)
RAC3 GAPs [cytosol] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
as a member of
RAC1 GAPs [cytosol] (Homo sapiens)
SRGAP [cytosol] (Homo sapiens)
as an input of
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)
as an output of
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)
as a component of
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
Inferred To
SRGAP2 [cytosol]
(Bos taurus)
SRGAP2 [cytosol]
(Canis familiaris)
SRGAP2 [cytosol]
(Gallus gallus)
SRGAP2 [cytosol]
(Sus scrofa)
srgp-1 [cytosol]
(Caenorhabditis elegans)
Srgap2 [cytosol]
(Mus musculus)
Srgap2 [cytosol]
(Rattus norvegicus)
srgap2 [cytosol]
(Danio rerio)
Ghost homologue of SRGAP2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001164108.1
,
XP_005277567.1
,
NP_056141.2
ENSEMBL
ENST00000573034
,
ENSP00000459615
OpenTargets
ENSG00000266028
HPA
ENSG00000266028-SRGAP2
PRO
O75044
Pharos - Targets
O75044
GlyGen
O75044
PDB
2DL8
,
5I6J
,
4RUG
,
4RTT
,
5I7D
,
5I6R
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.867
7
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.816
6
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.802
6
UniProt:O75044 SRGAP2
1
SRGAP2 [cytosol]
(R-HSA-195131)
0.74
5
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.706
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.706
4
UniProt:O14744 PRMT5
3
PRMT5 [cytosol]
(R-HSA-191876)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
0.611
4
UniProt:P48023 FASLG
1
FASLG(1-281) [extracellular region]
(R-HSA-66212)
0.609
2
UniProt:O95466 FMNL1
1
FMNL1 [cytosol]
(R-HSA-5663224)
0.602
3
UniProt:Q9Y6N7 ROBO1
3
p-Y1073-ROBO1 [plasma membrane]
(R-HSA-375979)
PolyUb-ROBO1 [plasma membrane]
(R-HSA-8986095)
ROBO1 [plasma membrane]
(R-HSA-204361)
0.558
3
UniProt:Q9NRI5 DISC1
0.553
2
UniProt:Q8N7C3 TRIMM
0.527
2
UniProt:Q6ZPF4
1
Fmnl3 [cytosol]
(R-MMU-5665760)
0.527
3
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