Phosphorylation of APC component of the destruction complex

Stable Identifier
R-HSA-195275
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of APC component of the destruction complex
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
APC is phosphorylated on the 20 aa repeats by CK1 and potentially GSK-3. This significantly increases the binding affinity of the APC 20 aa repeats for beta-catenin, causing one of them to bind b-catenin in the same region as beta-catenin binds Axin, thus displacing beta-catenin from Axin ( Step 5 above) (Reviewed in Kimelman, 2006).
Literature References
PubMed ID Title Journal Year
16753179 The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin

Liu, J, Zheng, J, Hinds, TR, Xing, Y, Xu, W

J Mol Biol 2006
Participants
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Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]

Physical Entity
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of APC component of the destruction complex (Bos taurus)
Phosphorylation of APC component of the destruction complex (Caenorhabditis elegans)
Phosphorylation of APC component of the destruction complex (Canis familiaris)
Phosphorylation of APC component of the destruction complex (Drosophila melanogaster)
Phosphorylation of APC component of the destruction complex (Gallus gallus)
Phosphorylation of APC component of the destruction complex (Mus musculus)
Phosphorylation of APC component of the destruction complex (Rattus norvegicus)
Phosphorylation of APC component of the destruction complex (Sus scrofa)
Authored
Kimelman, D  (2007-04-03)
Reviewed
Pagano, M  (2007-04-27)
Created
Matthews, L  (2007-04-03)
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