Association of beta-catenin with the destruction complex

Stable Identifier
R-HSA-195304
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Beta-catenin associates with the destruction complex through an interaction with Axin and or APC. This association may also involve interactions with the 15 aa repeats in APC (Spink et al., 2001) or the third APC 20aa repeat and its N-terminal flanking residues (Ha et al., 2004, Xing et al., 2004; Liu et al., 2006).
Literature References
PubMed ID Title Journal Year
15327769 Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function

Kimelman, D, Stenkamp, R, Hinds, TR, Xing, Y, Clements, WK, Le Trong, I, Xu, W

Mol Cell 2004
Participants
Participates
Orthologous Events
Reviewed
Created
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