Reactome | RAC2 [cytosol]

RAC2 [cytosol]

Stable Identifier

R-HSA-195343

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Rac2

Icon

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RAC2 GTPase cycle (Homo sapiens)
        
        RAC2 GDIs block activation of RAC2 (Homo sapiens)
        
        ARHGDIA:RAC2:GDP [cytosol] (Homo sapiens)
        
        RAC2:GDP [cytosol] (Homo sapiens)
        
        RAC2 [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - PCP/CE pathway (Homo sapiens)
      - ppDVL recruits RAC (Homo sapiens)
        
        RAC:GTP [cytosol] (Homo sapiens)
        
        RAC [cytosol] (Homo sapiens)
        
        RAC2 [cytosol] (Homo sapiens)
        
        pp-DVL:RAC:GTP [plasma membrane] (Homo sapiens)
        
        RAC:GTP [cytosol] (Homo sapiens)
        
        RAC [cytosol] (Homo sapiens)
        
        RAC2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P15153 RAC2

Gene Names

RAC2

Chain

chain:1-189, propeptide:190-192

Reference Genes

BioGPS Gene:5880 RAC2

COSMIC (genes):RAC2 RAC2

CTD Gene:5880 RAC2

dbSNP Gene:5880 RAC2

ENSEMBL:ENSG00000128340 RAC2

HGNC:9802 RAC2

KEGG:hsa:5880 RAC2

Monarch:5880 RAC2

NCBI Gene:5880 RAC2

OMIM:602049 RAC2

UCSC:P15153 RAC2

Reference Transcript

RefSeq:NM_002872.5 RAC2

Other Identifiers

11744263_s_at

16934749

207419_3p_s_at

207419_PM_s_at

207419_s_at

213603_PM_s_at

213603_s_at

2989055

32736_at

32737_at

3960062

3960063

3960064

3960065

3960066

3960067

3960068

3960069

3960070

3960071

3960078

3960079

3960080

3960081

3960082

5880

8075910

A_23_P218770

A_23_P218774

A_24_P228717

A_33_P3220160

GE80267

GE81848

GO:0000166

GO:0003924

GO:0005515

GO:0005525

GO:0005635

GO:0005737

GO:0005741

GO:0005789

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005925

GO:0006935

GO:0007010

GO:0007015

GO:0007163

GO:0007165

GO:0007186

GO:0007264

GO:0008283

GO:0008360

GO:0010310

GO:0010592

GO:0010810

GO:0016020

GO:0016787

GO:0019887

GO:0019901

GO:0030027

GO:0030031

GO:0030036

GO:0030670

GO:0030865

GO:0031410

GO:0032956

GO:0042129

GO:0042554

GO:0042995

GO:0043020

GO:0043131

GO:0043304

GO:0045453

GO:0045730

GO:0060263

GO:0060753

GO:0070062

GO:0070662

GO:0070668

GO:0071593

GO:0090023

GO:1902622

GO:1903955

HMNXSV003023793

HMNXSV003032615

Hs.301175.1.S1_3p_s_at

ILMN_1709795

M64595_at

PH_hs_0015519

TC22000725.hg

Participates

as a component of

RAC2:GDP [cytosol] (Homo sapiens)

as a member of

VAV1 effectors [cytosol] (Homo sapiens)

as a candidate of

RAC [cytosol] (Homo sapiens)

Other forms of this molecule

RAC2 [endoplasmic reticulum membrane]

RAC2 [mitochondrial outer membrane]

RAC2 [phagocytic vesicle membrane]

RAC2 [plasma membrane]

Inferred To

RAC3 [cytosol] (Canis familiaris)

RAC2 [cytosol] (Bos taurus)

RAC2 [cytosol] (Canis familiaris)

RAC2 [cytosol] (Gallus gallus)

RAC2 [cytosol] (Sus scrofa)

rac2 [cytosol] (Danio rerio)

rac2 [cytosol] (Xenopus tropicalis)

Homologues of RAC2 [cytosol] (Canis familiaris)

Rac2 [cytosol] (Mus musculus)

Rac2 [cytosol] (Rattus norvegicus)

racD [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_002863.1

ENSEMBL

ENST00000249071, ENSP00000249071, ENSG00000128340

OpenTargets

ENSG00000128340

GeneCards

RAC2

HPA

ENSG00000128340-RAC2

PRO

P15153

Pharos - Targets

P15153

GlyGen

P15153

Orphanet

RAC2

HMDB Protein

HMDBP01788

PDB

2W2X, 2W2T, 2W2V, 1DS6

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.564	2
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.556	3
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.527	2