Reactome | SC5D [endoplasmic reticulum membrane]

SC5D [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-195662

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

SC5DL, lathosterol oxidase, sterol-C5-desaturase

Locations in the PathwayBrowser for interactor UniProt:P62079 TSPAN5

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External Reference Information

External Reference

UniProt:O75845 SC5D

Gene Names

SC5D, SC5DL

Chain

chain:1-299

Reference Genes

BioGPS Gene:6309 SC5D

COSMIC (genes):SC5D SC5D

CTD Gene:6309 SC5D

dbSNP Gene:6309 SC5D

ENSEMBL:ENSG00000109929 SC5DL

ENSEMBL_homo_sapiens_GENE:ENSG00000109929.10 SC5D

HGNC:10547 SC5D

KEGG Gene (Homo sapiens):6309 SC5D

Monarch:6309 SC5D

NCBI Gene:6309 SC5D

OMIM:602286 SC5D

UCSC:O75845 SC5D

Reference Transcript

Other Identifiers

11717949_a_at

11717950_s_at

11733780_a_at

11757184_a_at

16732569

211423_PM_s_at

211423_s_at

215064_PM_at

215064_at

33421_s_at

3352906

3352907

3352910

3352911

3352912

3352914

3352918

3352919

3352922

3352923

3352924

3352925

3352926

3352927

3352928

3352929

3352930

3352931

6309

7944656

90247_r_at

90249_at

A_23_P372888

A_23_P98446

A_32_P41026

D85181_at

GE61492

GE81697

GO:0000248

GO:0003824

GO:0005506

GO:0005783

GO:0005789

GO:0006629

GO:0006694

GO:0008202

GO:0008610

GO:0016020

GO:0016126

GO:0016491

GO:0033489

GO:0033490

GO:0043226

GO:0050046

HMNXSV003021130

Hs.287749.0.S1_3p_at

ILMN_1672680

ILMN_1677607

ILMN_1727236

PH_hs_0023499

TC11001106.hg

g1906795_3p_a_at

Participates

as an output of

Expression of Lathosterol Oxidase (SC5D, SC5DL) (Homo sapiens)

Inferred To

SC5D [endoplasmic reticulum membrane] (Bos taurus)

SC5D [endoplasmic reticulum membrane] (Canis familiaris)

SC5D [endoplasmic reticulum membrane] (Gallus gallus)

SC5D [endoplasmic reticulum membrane] (Sus scrofa)

Sc5d [endoplasmic reticulum membrane] (Mus musculus)

Sc5d [endoplasmic reticulum membrane] (Rattus norvegicus)

ERG3 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

erg32 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

sc5d [endoplasmic reticulum membrane] (Danio rerio)

sc5d [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001020127.1, NP_008849.2

OpenTargets

ENSG00000109929

GeneCards

O75845

HPA

ENSG00000109929-SC5D

Ensembl

ENSP00000376539, ENSG00000109929, ENSP00000264027, ENST00000392789, ENST00000264027

ZINC target

O75845

PRO

O75845

Pharos - Targets

O75845

Orphanet

15249

HMDB Protein

HMDBP00135

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:P32241 VIPR1	1	VIPR1 [plasma membrane] (R-HSA-420157)	0.527	2
UniProt:P62079 TSPAN5	2	TSPAN5 [plasma membrane] (R-HSA-9010031) TSPAN5 [endoplasmic reticulum lumen] (R-HSA-9010081)	0.527	2
UniProt:Q8TDU9 RXFP4	1	RXFP4 [plasma membrane] (R-HSA-444826)	0.527	2
UniProt:Q9GZM5 YIPF3			0.527	2
UniProt:P41587 VIPR2	1	VIPR2 [plasma membrane] (R-HSA-420227)	0.527	2
UniProt:Q8IVM8 S22A9			0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [azurophil granule membrane] (R-HSA-6799517) C3AR1 [specific granule membrane] (R-HSA-6799516)	0.527	2

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