Reactome | MAGED1 [cytosol]

MAGED1 [cytosol]

Stable Identifier

R-HSA-196002

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NRAGE, Melanoma-associated antigen D1, MGD1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q9BYJ9 YTHD1

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Signal Transduction (Homo sapiens)

- Death Receptor Signaling (Homo sapiens)
  - p75 NTR receptor-mediated signalling (Homo sapiens)
    - Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
      - NRAGE signals death through JNK (Homo sapiens)
        
        NGF:p75NTR complex binds to NRAGE (Homo sapiens)
        
        MAGED1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y5V3 MAGED1

Gene Names

MAGED1, NRAGE, PP2250, PRO2292

Chain

chain:1-778

Reference Genes

COSMIC (genes):MAGED1 MAGED1

dbSNP Gene:9500 MAGED1

ENSEMBL:ENSG00000179222 MAGED1

Participates

as a component of

as an input of

Interactors (102)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.805	9
UniProt:P35219 CAH8			0.805	9
UniProt:Q8NG27 PJA1	1	PJA1 [cytosol] (R-HSA-975989)	0.74	7
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.718	6
UniProt:Q92734 TFG	7	TFG [cytosol] (R-HSA-5688159) TFG(1-240)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699806) TFG(1-138)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699874) TFG(1-193)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699887) TFG(1-193)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9702029) TFG(1-240)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702038) TFG(1-138)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9702019)	0.718	8
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.718	6
UniProt:Q99750 MDFI			0.718	6
UniProt:Q9BQY4 RHXF2			0.718	6
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.718	6
UniProt:Q8WU79 SMAP2			0.718	6
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.666	4
UniProt:P78337 PITX1			0.666	4
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.666	4
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.666	4
UniProt:Q15038 DAZP2			0.666	4
UniProt:O95400 CD2BP2	1	CD2BP2 [nucleoplasm] (R-HSA-72054)	0.618	3
UniProt:Q96MN9 ZN488			0.556	3
UniProt:Q9BYJ9 YTHD1			0.556	3
UniProt:Q6ZRY4 RBPS2			0.556	3
UniProt:Q86U06 RBM23			0.556	3
IntAct:EBI-10214943 112401			0.556	3
UniProt:A0A0S2Z4G9 A0A0S2Z4G9			0.556	3
UniProt:P0CG20 PRR35			0.556	3
UniProt:Q86UY5 FAM83A	1	FAM83A [cytosol] (R-HSA-9851391)	0.556	3
UniProt:Q8IYR0 CF206			0.556	3
IntAct:EBI-16428938 CCSB ISOFORM ID			0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:P86480 PR20D			0.556	3
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.556	3
UniProt:A0A0S2Z4Q4 A0A0S2Z4Q4			0.556	3
UniProt:Q93062 RBPMS			0.556	3
UniProt:Q9BWX5 GATA5	1	GATA5 [nucleoplasm] (R-HSA-996731)	0.556	3
UniProt:Q5T4B2 GT253			0.556	3
UniProt:Q96HA1-2 POM121			0.556	3
UniProt:O43251-10 RBFOX2			0.556	3
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.556	3
UniProt:Q5TAL4 Q5TAL4			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q12951-2 FOXI1			0.556	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.556	3
UniProt:Q6P1W5 CA094			0.556	3
UniProt:Q96HR8 NAF1			0.556	3
UniProt:O75553 DAB1	2	DAB1 [cytosol] (R-HSA-8855236) p-Y198,220,232-DAB1 [cytosol] (R-HSA-8855227)	0.556	3
UniProt:Q9Y6W3 CAPN7	1	CAPN7 [cytosol] (R-HSA-8848633)	0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:Q16637 SMN1	2	SMN1 [nucleoplasm] (R-HSA-191892) SMN1 [cytosol] (R-HSA-191839)	0.556	3
UniProt:Q8IVS8 GLYCTK	1	GLYCTK [cytosol] (R-HSA-6799244)	0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3
UniProt:Q3LI64 KRTAP6-1	1	KRTAP6-1 [cytosol] (R-HSA-6810298)	0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q5W5X9 TTC23			0.556	3
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.556	3
UniProt:O00468-6 O004686			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q15915 ZIC1	1	ZIC1 [nucleoplasm] (R-HSA-9731648)	0.556	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	3
UniProt:Q9BTL3 RAMAC			0.556	3
UniProt:O43251 RBFOX2	1	RBFOX2 [nucleoplasm] (R-HSA-6803504)	0.556	3
UniProt:P23415 GLRA1	1	GLRA1 [plasma membrane] (R-HSA-975392)	0.556	3
UniProt:P56693 SOX10	2	p-T240,T244-SOX10 [nucleoplasm] (R-HSA-9824578) SOX10 [nucleoplasm] (R-HSA-9613639)	0.556	3
UniProt:O60548 FOXD2			0.556	3
UniProt:Q68DK2-5 ZFYVE26			0.556	3
UniProt:Q5I0X7 TTC32			0.556	3
UniProt:P35711-4 SOX5			0.556	3
UniProt:Q92615 LAR4B			0.556	3
UniProt:A0A0S2Z5X4 A0A0S2Z5X4			0.556	3
UniProt:O75593 FOXH1	1	FOXH1 [nucleoplasm] (R-HSA-1225914)	0.556	3
UniProt:O95947 TBX6	1	TBX6 [nucleoplasm] (R-HSA-9793377)	0.556	3
UniProt:Q6PIA0 Q6PIA0			0.556	3
UniProt:A8MTQ0 NOTO	1	NOTO [nucleoplasm] (R-HSA-9796216)	0.556	3
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.556	3
UniProt:Q01085-2 TIAL1			0.556	3
UniProt:Q9Y5R5 DMRT2			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q9Y5R4 HEMK1			0.556	3
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.556	3
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.556	3
UniProt:O95872 GPAN1			0.556	3
UniProt:Q5VV41 ARHGEF16	1	ARHGEF16 [cytosol] (R-HSA-2976623)	0.556	3
IntAct:EBI-22320186 CCSB ORF ID			0.556	3
UniProt:O75360 PROP1			0.556	3
UniProt:P31274 HXC9			0.556	3
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.556	3
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.556	3
UniProt:Q99996-2 AKAP9			0.556	3
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.556	3
UniProt:O43711 TLX3			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.556	3
UniProt:Q96PV6 LENG8			0.556	3
UniProt:Q8NDC0 MISSL			0.556	3
UniProt:Q6ZR37 PKHG7			0.527	2
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.508	2
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.488	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	2
UniProt:Q9WMX2-PRO_0000037541			0.488	2
UniProt:Q93062-3 RBPMS			0.488	2
UniProt:P12504 VIF			0.462	2

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