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About
What is Reactome ?
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Team
Scientific Advisory Board
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Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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How do I search ?
Details Panel
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Cytomics
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FAQ
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ACTG1 [plasma membrane]
Stable Identifier
R-HSA-196044
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
cytoplamic actin 2
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
ANG binds F-actin (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
F-actin:ANG [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
Clathrin internalises EPH:EFN complexes (Homo sapiens)
EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
Dissociation of BRAF/RAF fusion complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
p-BRAF and RAF fusion dimers bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
p-BRAF and RAF fusion dimers phosphorylate MAP2Ks (Homo sapiens)
p-BRAF/RAF fusion dimers:MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Signaling by RAF1 mutants (Homo sapiens)
Dissociation of RAS:RAF1 mutant complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated mutant RAF1 complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAF1 mutant complexes phosphorylate MAP2K dimer (Homo sapiens)
activated RAF1 mutant:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Signaling by high-kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Dissociation of high activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
High kinase activity BRAF complexes phosphorylate MAP2Ks (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
High kinase activity BRAF mutants bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:MAP2K:MAPK complex [cytosol] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Dissociation of moderate activity BRAF complexes (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
MAP2K and MAPK activation (Homo sapiens)
Dissociation of RAS:RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
MAP2Ks phosphorylate MAPKs (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAF phosphorylates MAP2K dimer (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAF/MAPK scaffolds [cytosol] (Homo sapiens)
Focal Adhesion/Focal contacts [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
f-actin [plasma membrane] (Homo sapiens)
actin:ATP [plasma membrane] (Homo sapiens)
actin [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Gap junction trafficking and regulation (Homo sapiens)
Gap junction trafficking (Homo sapiens)
Gap junction degradation (Homo sapiens)
Formation of annular gap junctions (Homo sapiens)
Dab2 is recruited to the junctional plaques (Homo sapiens)
planar gap junction plaques [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
planar gap junction plaques [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Dynamin is recruited to the gap junction plaque (Homo sapiens)
Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Homo sapiens)
planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
planar gap junction plaques [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
planar gap junction plaques [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
Internalization of gap junction plaques (Homo sapiens)
Planar gap junction plaques associated with Dab2 and Dynamin [plasma membrane] (Homo sapiens)
planar gap junction plaques associated with Dab2 [plasma membrane] (Homo sapiens)
planar gap junction plaques [plasma membrane] (Homo sapiens)
F-actin [plasma membrane] (Homo sapiens)
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
ACTG1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63261 ACTG1
Gene Names
ACTG1, ACTG
Chain
chain:1-375, initiator methionine:, chain:2-375
Reference Genes
BioGPS Gene:71 ACTG1
COSMIC (genes):ACTG1 ACTG1
CTD Gene:71 ACTG1
dbSNP Gene:71 ACTG1
ENSEMBL:ENSG00000184009 ACTG1
ENSEMBL_homo_sapiens_GENE:ENSG00000184009.13 ACTG1
ENSEMBL_homo_sapiens_GENE:ENSG00000291420.1 ACTG1
HGNC:144 ACTG1
KEGG Gene (Homo sapiens):71 ACTG1
Monarch:71 ACTG1
NCBI Gene:71 ACTG1
OMIM:102560 ACTG1
UCSC:P63261 ACTG1
Reference Transcript
RefSeq:NM_001199954.1 ACTG1
RefSeq:NM_001614.3 ACTG1
Other Identifiers
11752959_x_at
11754217_x_at
11757807_x_at
11758042_x_at
11762785_x_at
16849849
201550_3p_x_at
201550_PM_x_at
201550_x_at
211970_PM_x_at
211970_x_at
211983_PM_x_at
211983_x_at
211995_3p_x_at
211995_PM_x_at
211995_x_at
212363_3p_x_at
212363_PM_x_at
212363_x_at
212988_PM_x_at
212988_x_at
213214_3p_x_at
213214_PM_x_at
213214_x_at
221607_3p_x_at
221607_PM_x_at
221607_x_at
224585_3p_x_at
224585_PM_x_at
224585_x_at
2349440
2387414
2644947
34160_at
3621802
3773933
3773934
3773935
3773936
3773937
3773938
3773940
3773942
3773946
3773947
3773948
3773949
3773951
3773952
3773953
3773954
3773956
3773969
43831_s_at
51746_f_at
71
8019183
A_23_P44037
GE80152
GO:0000166
GO:0001525
GO:0001738
GO:0002376
GO:0003824
GO:0005198
GO:0005200
GO:0005515
GO:0005522
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005911
GO:0005925
GO:0007010
GO:0007155
GO:0007409
GO:0010628
GO:0015629
GO:0016020
GO:0016192
GO:0016787
GO:0019901
GO:0030016
GO:0030154
GO:0030335
GO:0030424
GO:0031410
GO:0031625
GO:0031941
GO:0034330
GO:0035267
GO:0035633
GO:0042060
GO:0042802
GO:0043226
GO:0043296
GO:0044305
GO:0045177
GO:0045202
GO:0045214
GO:0045335
GO:0048856
GO:0048870
GO:0051492
GO:0051893
GO:0070062
GO:0070527
GO:0071346
GO:0072562
GO:0090303
GO:0097433
GO:0098542
GO:0098685
GO:0098973
GO:0098974
GO:0120192
GO:0120220
GO:0150111
GO:1900242
GO:1902396
HMNXSV003039797
HMNXSV003044768
Hs.14376.2.A1_3p_x_at
Hs.14376.3.A1_3p_a_at
Hs.14376.3.A1_3p_x_at
Hs.14376.4.A1_3p_x_at
Hs.14376.5.A1_3p_a_at
Hs.14376.5.A1_3p_x_at
Hs.14376.6.S1_3p_a_at
Hs.14376.6.S1_3p_s_at
Hs.14376.7.A1_3p_a_at
Hs.14376.7.A1_3p_x_at
Hs.14376.9.A1_3p_a_at
Hs.14376.9.A1_3p_x_at
ILMN_1704961
ILMN_2053178
M19283_at
PH_hs_0028775
PH_hs_0031012
TC06001971.hg
TC17001952.hg
TC17002825.hg
g11038618_3p_a_at
g11038618_3p_s_at
g12804934_3p_a_at
g12804934_3p_s_at
g12804934_3p_x_at
Participates
as a member of
actin [plasma membrane] (Homo sapiens)
as a candidate of
ACTB, ACTG1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
ACTG1 [cytosol]
ACTG1 [lysosomal membrane]
Inferred To
Act5C [plasma membrane]
(Drosophila melanogaster)
Actg1 [plasma membrane]
(Mus musculus)
Actg1 [plasma membrane]
(Rattus norvegicus)
act-2 [plasma membrane]
(Caenorhabditis elegans)
ARP9 [plasma membrane]
(Saccharomyces cerevisiae)
actb [plasma membrane]
(Xenopus tropicalis)
Homologues of ACTG1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of ACTG1 [plasma membrane]
(Drosophila melanogaster)
Homologues of ACTG1 [plasma membrane]
(Schizosaccharomyces pombe)
act-4 [plasma membrane]
(Caenorhabditis elegans)
act26 [plasma membrane]
(Dictyostelium discoideum)
act-1 [plasma membrane]
(Caenorhabditis elegans)
Act42A [plasma membrane]
(Drosophila melanogaster)
actbb [plasma membrane]
(Danio rerio)
arp9 [plasma membrane]
(Schizosaccharomyces pombe)
ACTG1 [plasma membrane]
(Bos taurus)
ACTG1 [plasma membrane]
(Canis familiaris)
ACTG1 [plasma membrane]
(Gallus gallus)
ACTG1 [plasma membrane]
(Sus scrofa)
act-3 [plasma membrane]
(Caenorhabditis elegans)
arp10 [plasma membrane]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001605.1
,
NP_001186883.1
OpenTargets
ENSG00000184009
HPA
ENSG00000184009-ACTG1
GeneCards
P63261
Ensembl
ENSP00000459119
,
ENST00000681842
,
ENSP00000477968
,
ENST00000570382
,
ENST00000575994
,
ENST00000576544
,
ENST00000575659
,
ENSP00000505060
,
ENSP00000506253
,
ENST00000573283
,
ENSP00000458162
,
ENSG00000184009
,
ENST00000575087
,
ENST00000615544
,
ENST00000575842
,
ENSP00000459124
,
ENST00000681052
,
ENST00000571721
,
ENST00000680227
,
ENSP00000460464
,
ENST00000679480
,
ENSP00000505193
,
ENSP00000466346
,
ENSP00000461672
,
ENST00000680727
,
ENSP00000460660
,
ENSP00000458435
,
ENST00000679778
,
ENSP00000506126
,
ENSP00000505235
,
ENSP00000506201
PRO
P63261
Pharos - Targets
P63261
Orphanet
17680
PDB
8DNF
,
7NVM
,
6WK1
,
6G2T
,
6V63
,
6CXJ
,
6CXI
,
6WK2
,
6V62
,
5JLH
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB [nucleoplasm]
(R-HSA-3321990)
ACTB [cytosol]
(R-HSA-201861)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [plasma membrane]
(R-HSA-196016)
0.951
16
UniProt:P23528 CFL1
3
CFL1 [cytosol]
(R-HSA-350751)
p-S3-CFL1 [cytosol]
(R-HSA-399813)
CFL1 [extracellular region]
(R-HSA-350747)
0.831
10
UniProt:Q08426 EHHADH
2
EHHADH [peroxisomal matrix]
(R-HSA-400155)
EHHADH [cytosol]
(R-HSA-9033147)
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
16
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.65
3
UniProt:P40692 MLH1
3
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.602
6
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.564
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
5
UniProt:P50552 VASP
1
VASP [cytosol]
(R-HSA-446323)
0.483
2
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