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DNM1 [lysosomal membrane]
Stable Identifier
R-HSA-196150
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal membrane
Synonyms
Dynamin-1
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Gap junction trafficking and regulation (Homo sapiens)
Gap junction trafficking (Homo sapiens)
Gap junction degradation (Homo sapiens)
Internalization of gap junction plaques (Homo sapiens)
Invaginating gap junction plaques [lysosomal membrane] (Homo sapiens)
Dynamin [lysosomal membrane] (Homo sapiens)
DNM1 [lysosomal membrane] (Homo sapiens)
Lysosomal degradation of gap junction plaques (Homo sapiens)
Invaginating gap junction plaques [lysosomal membrane] (Homo sapiens)
Dynamin [lysosomal membrane] (Homo sapiens)
DNM1 [lysosomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q05193 DNM1
Gene Names
DNM1, DNM
Chain
chain:1-864
Reference Genes
BioGPS Gene:1759 DNM1
COSMIC (genes):DNM1 DNM1
CTD Gene:1759 DNM1
dbSNP Gene:1759 DNM1
ENSEMBL:ENSG00000106976 DNM1
ENSEMBL_homo_sapiens_GENE:ENSG00000106976.22 DNM1
HGNC:2972 DNM1
KEGG Gene (Homo sapiens):1759 DNM1
Monarch:1759 DNM1
NCBI Gene:1759 DNM1
OMIM:602377 DNM1
UCSC:Q05193 DNM1
Reference Transcript
RefSeq:NM_001288738.1 DNM1
RefSeq:XM_005251769.2 DNM1
RefSeq:NM_001288737.1 DNM1
RefSeq:XM_005251768.2 DNM1
RefSeq:NM_001005336.2 DNM1
RefSeq:NM_004408.3 DNM1
RefSeq:NM_001288739.1 DNM1
RefSeq:XM_017014371.1 DNM1
Other Identifiers
11720616_a_at
11754476_x_at
11761584_x_at
17089549
1759
215116_PM_s_at
215116_s_at
3190243
3190244
3190247
3190249
3190250
3190251
3190252
3190253
3190254
3190255
3190256
3190260
3190262
3190272
3190273
3190274
3190276
3190279
3190281
3190282
3190283
3190284
3190286
3190287
3190292
3190293
3190294
3190295
3190296
3190297
3190298
3190302
3190304
32138_at
3603087
3605040
8158183
A_23_P135273
A_33_P3329419
GE57587
GE83830
GO:0000166
GO:0001917
GO:0003723
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005546
GO:0005547
GO:0005576
GO:0005615
GO:0005737
GO:0005856
GO:0005874
GO:0005886
GO:0006897
GO:0006898
GO:0007032
GO:0008017
GO:0008092
GO:0008289
GO:0016020
GO:0016185
GO:0016192
GO:0016787
GO:0019003
GO:0019901
GO:0023052
GO:0030117
GO:0030139
GO:0031410
GO:0031623
GO:0042802
GO:0042803
GO:0043226
GO:0048488
GO:0050804
GO:0051260
GO:0061024
GO:0065003
GO:0070062
GO:0098684
GO:0098793
GO:0098835
GO:0098978
HMNXSV003035649
HMNXSV003055054
Hs.166161.2.S1_3p_a_at
ILMN_1805200
L07807_s_at
TC09000679.hg
TC09000680.hg
TC15000502.hg
Participates
as a candidate of
Dynamin [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
DNM1 [cytosol]
DNM1 [plasma membrane]
Inferred To
DNM1 [lysosomal membrane]
(Bos taurus)
DNM1 [lysosomal membrane]
(Caenorhabditis elegans)
DNM1 [lysosomal membrane]
(Canis familiaris)
DNM1 [lysosomal membrane]
(Drosophila melanogaster)
DNM1 [lysosomal membrane]
(Gallus gallus)
DNM1 [lysosomal membrane]
(Mus musculus)
DNM1 [lysosomal membrane]
(Rattus norvegicus)
DNM1 [lysosomal membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001275668.1
,
NP_001275667.1
,
NP_004399.2
,
XP_005251826.1
,
NP_001275666.1
,
NP_001005336.1
,
XP_016869860.1
,
XP_005251825.1
ZINC - World Drugs
DYN1_HUMAN
OpenTargets
ENSG00000106976
ZINC - Substances
DYN1_HUMAN
ZINC target
Q05193
PRO
Q05193
PDB
2X2E
,
1DYN
,
6DLV
,
4UUK
,
2DYN
,
2X2F
,
5D3Q
,
3ZYS
,
3SNH
,
6S9A
,
3ZYC
,
4UUD
,
7AX3
,
6DLU
GeneCards
Q05193
HPA
ENSG00000106976-DNM1
Ensembl
ENSP00000487310
,
ENST00000372923
,
ENSP00000345680
,
ENST00000627543
,
ENSP00000362014
,
ENSG00000106976
,
ENST00000475805
,
ENST00000341179
,
ENSP00000377219
,
ENSP00000419225
,
ENSP00000420045
,
ENST00000393594
,
ENST00000486160
Pharos - Targets
Q05193
Orphanet
23223
ZINC - Predictions - Purchasable
DYN1_HUMAN
HMDB Protein
HMDBP08363
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q05193 DNM1
3
DNM1 [cytosol]
(R-HSA-2213182)
DNM1 [lysosomal membrane]
(R-HSA-196150)
DNM1 [plasma membrane]
(R-HSA-177488)
0.931
13
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.829
7
UniProt:Q9Y5X1 SNX9
3
SNX9 [cytosol]
(R-HSA-8867737)
SNX9 [Golgi membrane]
(R-HSA-432988)
SNX9 [cytoplasmic vesicle membrane]
(R-HSA-432990)
0.775
5
UniProt:P49418 AMPH
1
AMPH [cytosol]
(R-HSA-8867728)
0.766
6
UniProt:Q96JI7 SPTCS
0.635
3
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.623
3
GTP [ChEBI:15996]
7
GTP [cilium]
(R-ALL-5617813)
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [Golgi membrane]
(R-ALL-1806221)
0.609
2
UniProt:Q96RU3 FNBP1
1
FNBP1 [cytosol]
(R-HSA-8862261)
0.576
5
ChEBI:51987 GDP-TETRAFLUOROALUMINATE
0.558
2
UniProt:P19804
5
NME2 [secretory granule lumen]
(R-RNO-6803277)
NME2 [extracellular region]
(R-RNO-6806464)
NME2 [ficolin-1-rich granule lumen]
(R-RNO-6803324)
NME2P1 [cytosol]
(R-RNO-6806876)
NME2 [cytosol]
(R-RNO-60024)
0.544
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.543
4
UniProt:Q8IVI9 NOSTRIN
2
NOSTRIN [endocytic vesicle membrane]
(R-HSA-535014)
NOSTRIN [plasma membrane]
(R-HSA-202134)
0.524
3
UniProt:Q8WV41 SNX33
0.524
2
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.524
2
UniProt:Q9QYW3 PHOCN
0.489
2
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