Reactome | PPP2R5A [cytosol]

PPP2R5A [cytosol]

Stable Identifier

R-HSA-196235

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP2A- 56 kDa regulatory subunit, alpha isoform

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Platelet sensitization by LDL (Homo sapiens)
    - PECAM-1 binds PP2A (Homo sapiens)
      - PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - p-PECAM:PP2A [plasma membrane] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        p-Y307-PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        PP2A dephosphorylates RAF1 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - RAF activation (Homo sapiens)
        
        PP2A dephosphorylates KSR1 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        PP2A dephosphorylates inactive RAFs (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate Formins (Homo sapiens)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - Degradation of beta-catenin by the destruction complex (Homo sapiens)
    - AXIN is phosphorylated in the destruction complex (Homo sapiens)
      - AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
    - Assembly of the destruction complex (Homo sapiens)
      - AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
    - Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)
      - RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
    - Association of beta-catenin with the destruction complex (Homo sapiens)
      - CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
    - Beta-catenin phosphorylation cascade (Homo sapiens)
      - Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)
        
        CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Homo sapiens)
        
        p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
        
        p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
        
        p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
    - Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
      - p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
        
        RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
    - Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
    - Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)
      - RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
        
        RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
    - Phosphorylation of APC component of the destruction complex (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
      - Beta-catenin is released from the destruction complex (Homo sapiens)
        
        CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
      - PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
        
        CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15172 PPP2R5A

Gene Names

PPP2R5A

Chain

initiator methionine:, chain:2-486

Reference Genes

BioGPS Gene:5525 PPP2R5A

COSMIC (genes):PPP2R5A PPP2R5A

CTD Gene:5525 PPP2R5A

dbSNP Gene:5525 PPP2R5A

ENSEMBL:ENSG00000066027 PPP2R5A

ENSEMBL_homo_sapiens_GENE:ENSG00000066027.12 PPP2R5A

HGNC:9309 PPP2R5A

KEGG Gene (Homo sapiens):5525 PPP2R5A

Monarch:5525 PPP2R5A

NCBI Gene:5525 PPP2R5A

OMIM:601643 PPP2R5A

UCSC:Q15172 PPP2R5A

Reference Transcript

Other Identifiers

11747765_a_at

11758204_s_at

16677228

202186_3p_x_at

202186_PM_x_at

202186_x_at

202187_PM_s_at

202187_s_at

2379016

2379017

2379018

2379020

2379024

2379026

2379028

2379033

2379034

2379035

2379036

2379039

2379040

2379041

2379043

2379045

2379046

2379047

2379048

3805314

5525

7909586

903_at

A_14_P126109

A_23_P256432

A_24_P134955

A_24_P251221

GE57772

GO:0000159

GO:0000775

GO:0003824

GO:0004721

GO:0005515

GO:0005634

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006470

GO:0006629

GO:0007165

GO:0016787

GO:0019888

GO:0019900

GO:0023052

GO:0030018

GO:0031430

GO:0035307

GO:0036211

GO:0043226

GO:0072542

GO:0072659

GO:0090219

GO:0098772

GO:0140096

GO:1903077

HMNXSV003033871

Hs.155079.0.A1_3p_a_at

Hs.155079.0.A1_3p_at

ILMN_1738784

ILMN_1821279

L42373_at

PH_hs_0009337

TC01001771.hg

g5453949_3p_a_at

Participates

as a component of

PPP2R5A-specific PP2A [cytosol] (Homo sapiens)

as a candidate of

PP2A regulatory subunit B56 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S28-PPP2R5A [cytosol]

Inferred To

par1 [cytosol] (Schizosaccharomyces pombe)

psrA [cytosol] (Dictyostelium discoideum)

RTS1 [cytosol] (Saccharomyces cerevisiae)

par2 [cytosol] (Schizosaccharomyces pombe)

wdb [cytosol] (Drosophila melanogaster)

Homologues of PPP2R5A [cytosol] (Schizosaccharomyces pombe)

PPP2R5A [cytosol] (Bos taurus)

PPP2R5A [cytosol] (Canis familiaris)

PPP2R5A [cytosol] (Gallus gallus)

PPP2R5A [cytosol] (Sus scrofa)

Ppp2r5a [cytosol] (Mus musculus)

Ppp2r5a [cytosol] (Rattus norvegicus)

pptr-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001186685.1, NP_006234.1

OpenTargets

ENSG00000066027

HPA

ENSG00000066027-PPP2R5A

GeneCards

Q15172

ZINC target

Q15172

Ensembl

ENST00000261461, ENST00000537030, ENSP00000442866, ENSP00000261461, ENSG00000066027

PRO

Q15172

Pharos - Targets

Q15172

PDB

6NTS

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	MeL-PPP2CA [nucleoplasm] (R-HSA-8857791) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) PPP2CA [nucleoplasm] (R-HSA-165978) PPP2CA [cytosol] (R-HSA-165971)	0.903	8
UniProt:Q86YF9 DZIP1	1	DZIP1 [nucleoplasm] (R-HSA-5635020)	0.666	4
UniProt:O96017 CHEK2	3	p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) CHEK2 [nucleoplasm] (R-HSA-113824) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784)	0.658	3
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) AXIN1 [cytosol] (R-HSA-195249)	0.527	2
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.527	3

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