Reactome | Beta-catenin phosphorylation cascade

Beta-catenin phosphorylation cascade

Stable Identifier

R-HSA-196299

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Degradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated phosphorylation at Thr41, Ser37 and Ser33 (Amit et al., 2002 ; Lui et al., 2002).

Literature References

PubMed ID	Title	Journal	Year
12000790	Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway Andersen, JS, Birman, Y, Mann, M, Ben-Shushan, E, Alkalay, I, Hatzubai, A, Amit, S, Ben-Neriah, Y	Genes Dev	2002
11955436	Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism Zhang, Z, Baeg, GH, Lin, X, Tan, Y, Li, Y, He, X, Semenov, M, Han, C, Liu, C	Cell	2002