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Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
Stable Identifier
R-HSA-1963587
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
PTPN18 binds ERBB2:EGFR heterodimers (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
GRB2 events in ERBB2 signaling (Homo sapiens)
GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
PI3K events in ERBB2 signaling (Homo sapiens)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
PLCG1 events in ERBB2 signaling (Homo sapiens)
PLCG1 binds to p-ERBB2:p-EGFR (Homo sapiens)
EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
PLCG1 phosphorylation by p-EGFR:p-ERBB2 (Homo sapiens)
EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
Participants
members
EGF:p-6Y-EGFR:p-6Y,Y1112-ERBB2 [plasma membrane]
(Homo sapiens)
candidates
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane]
(Homo sapiens)
Participates
as an input of
PTPN18 binds ERBB2:EGFR heterodimers (Homo sapiens)
GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer (Homo sapiens)
Shc1 binds phosphorylated ERBB2:EGFR heterodimers (Homo sapiens)
PLCG1 binds to p-ERBB2:p-EGFR (Homo sapiens)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Homo sapiens)
as a component of
Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane] (Homo sapiens)
Shc1:Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:PLCG1 [plasma membrane] (Homo sapiens)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Homo sapiens)
as an output of
PLCG1 phosphorylation by p-EGFR:p-ERBB2 (Homo sapiens)
Inferred To
p-ERBB2 heterodimers [plasma membrane]
(Caenorhabditis elegans)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
(Canis familiaris)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
(Drosophila melanogaster)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
(Gallus gallus)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
(Mus musculus)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
(Rattus norvegicus)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
(Sus scrofa)
Ghost homologue of Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
(Bos taurus)
Ghost homologue of Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
(Danio rerio)
Ghost homologue of Phosphorylated ERBB2:EGFR heterodimers [plasma membrane]
(Xenopus tropicalis)
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