STING binds TRIM32 or TRIM56

Stable Identifier
R-HSA-1964496
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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STING binds TRIM32 or TRIM56
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Tripartite motif (TRIM) family member TRIM56 was shown to interact with STING upon DNA stimulation promoting lysine 63-linked ubiquitination of STING and type I IFN induction (Tsuchida T et al. 2010). Another member of the family TRIM32 has also been implicated in K63-linked ubiquitination of STING (Zhang J et al. 2012).
Literature References
PubMed ID Title Journal Year
21074459 The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

Tsuchida, T, Zou, J, Saitoh, T, Kumar, H, Abe, T, Matsuura, Y, Kawai, T, Akira, S

Immunity 2010
22745133 TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

Zhang, J, Hu, MM, Wang, YY, Shu, HB

J. Biol. Chem. 2012
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Orthologous Events
STING binds TRIM32 or TRIM56 (Bos taurus)
STING binds TRIM32 or TRIM56 (Danio rerio)
STING binds TRIM32 or TRIM56 (Drosophila melanogaster)
STING binds TRIM32 or TRIM56 (Gallus gallus)
STING binds TRIM32 or TRIM56 (Mus musculus)
STING binds TRIM32 or TRIM56 (Rattus norvegicus)
STING binds TRIM32 or TRIM56 (Sus scrofa)
Authored
Shamovsky, V  (2013-02-06)
Reviewed
D'Eustachio, P  (2013-02-11)
Jin, L  (2013-05-22)
Wu, J  (2013-05-22)
Created
Shamovsky, V  (2011-11-04)
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