Reactome | 2xPPCS ligates PPanK with Cys

2xPPCS ligates PPanK with Cys

Stable Identifier

R-HSA-196753

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(R)-4'-phosphopantothenate + ATP + L-cysteine => AMP + diphosphate + H(+) + N-((R)-4-phosphopantothenoyl)-L-cysteine

ReviewStatus

5/5

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The conjugation of cysteine (Cys) and 4'- phosphopantothenate (PPanK) to form 4-phosphopantothenoylcysteine (PPC) , coupled to the conversion of ATP to AMP and pyrophosphate, is catalyzed by cytosolic phosphopantothenate-cysteine ligase (PPCS aka Phosphopantothenoylcysteine synthase or PPC synthase). Mammalian PPCS prefers ATP to CTP, unlike the E. coli ortholog (Daughtery et al. 2002; Manoj et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12906824	Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. Manoj, N, Strauss, E, Begley, TP, Ealick, SE	Structure	2003
11923312	Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics Daugherty, M, Polanuyer, B, Farrell, M, Scholle, M, Lykidis, A, de Crecy-Lagard, V, Osterman, A	J Biol Chem	2002