Reactome | COASY phosphorylates DP-CoA

COASY phosphorylates DP-CoA

Stable Identifier

R-HSA-196773

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

Synonyms

3'-dephospho-CoA + ATP => ADP + CoA + H(+), Phosphorylation of dephospho-CoA to produce CoA

ReviewStatus

5/5

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The kinase activity of CoA synthase (COASY) catalyzes the phosphorylation of dephospho-CoA to form Coenzyme A (CoA-SH). The enzyme is located in the mitochondrial outer membrane (Daugherty et al. 2002; Zhyvoloup et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
14514684	Subcellular localization and regulation of coenzyme A synthase Panasyuk, G, Kyyamova, R, Lyzogubov, V, Zhyvoloup, A, Filonenko, V, Valovka, T, Nemazanyy, I, Gorbenko, O, Wang, ML, Fenton, T, Foxon, R, Gout, IT, Matsuka, G, Rebholz, H, Usenko, V	J Biol Chem	2003
11994049	Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase) Worrall, DM, Aghajanian, S	Biochem J	2002