Reactome | COASY phosphorylates DP-CoA

COASY phosphorylates DP-CoA

Stable Identifier

R-HSA-196773

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

Synonyms

3'-dephospho-CoA + ATP => ADP + CoA + H(+), Phosphorylation of dephospho-CoA to produce CoA

ReviewStatus

5/5

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The kinase activity of CoA synthase (COASY) catalyzes the phosphorylation of dephospho-CoA to form Coenzyme A (CoA-SH). The enzyme is located in the mitochondrial outer membrane (Daugherty et al. 2002; Zhyvoloup et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
14514684	Subcellular localization and regulation of coenzyme A synthase Zhyvoloup, A, Nemazanyy, I, Panasyuk, G, Valovka, T, Fenton, T, Rebholz, H, Wang, ML, Foxon, R, Lyzogubov, V, Usenko, V, Kyyamova, R, Gorbenko, O, Matsuka, G, Filonenko, V, Gout, IT	J Biol Chem	2003
11994049	Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase) Aghajanian, S, Worrall, DM	Biochem J	2002