Coenzyme A biosynthesis

Stable Identifier
Homo sapiens
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Coenzyme A (CoA) is a ubiquitous cofactor that functions as an acyl group carrier in diverse processes including fatty acid metabolism and the TCA cycle (Lipmann 1953). It is synthesized from the vitamin pantothenate in a sequence of five reactions (Daugherty et al. 2002; Leonardi et al. 2005; Robishaw and Neely 1985). These reactions all occur in the cytosol or the mitochondrial intermembrane space (Leonardi et al. 2005). A recently described transport protein appears to mediate the uptake of Coenzyme A into the mitochondrial matrix (Prohl et al. 2001).
Literature References
PubMed ID Title Journal Year
11158296 The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix

Prohl, C, Lill, R, Kispal, G, Diekert, K, Bedekovics, T, Pelzer, W, Kmita, H

Mol Cell Biol 2001
15893380 Coenzyme A: back in action

Leonardi, R, Zhang, YM, Rock, CO, Jackowski, S

Prog Lipid Res 2005
13032008 On chemistry and function of coenzyme A

Lipmann, F

Bacteriol Rev 1953
2981478 Coenzyme A metabolism

Robishaw, JD, Neely, JR

Am J Physiol 1985
11923312 Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics

Osterman, A, Farrell, M, Daugherty, M, de Crecy-Lagard, V, Scholle, M, Polanuyer, B, Lykidis, A

J Biol Chem 2002
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