Reactome | Coenzyme A biosynthesis

Coenzyme A biosynthesis

Stable Identifier

R-HSA-196783

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Coenzyme A (CoA) is a ubiquitous cofactor that functions as an acyl group carrier in diverse processes including fatty acid metabolism and the TCA cycle (Lipmann 1953). It is synthesized from the vitamin pantothenate in a sequence of five reactions (Daugherty et al. 2002; Leonardi et al. 2005; Robishaw and Neely 1985). These reactions all occur in the cytosol or the mitochondrial intermembrane space (Leonardi et al. 2005). A recently described transport protein appears to mediate the uptake of Coenzyme A into the mitochondrial matrix (Prohl et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11158296	The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix Prohl, C, Lill, R, Kispal, G, Diekert, K, Bedekovics, T, Pelzer, W, Kmita, H	Mol Cell Biol	2001
15893380	Coenzyme A: back in action Leonardi, R, Zhang, YM, Rock, CO, Jackowski, S	Prog Lipid Res	2005
13032008	On chemistry and function of coenzyme A Lipmann, F	Bacteriol Rev	1953
2981478	Coenzyme A metabolism Robishaw, JD, Neely, JR	Am J Physiol	1985
11923312	Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics Osterman, A, Farrell, M, Daugherty, M, de Crecy-Lagard, V, Scholle, M, Polanuyer, B, Lykidis, A	J Biol Chem	2002