Reactome | 3xPPCDC:3FMN decarboxylates PPC

3xPPCDC:3FMN decarboxylates PPC

Stable Identifier

R-HSA-196840

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(R)-4'-phosphopantetheine + ATP + H(+) => 3'-dephospho-CoA + diphosphate

ReviewStatus

5/5

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The decarboxylation of phosphopantothenoylcysteine (PPC) to 4'-phosphopantetheine (PPANT) is carried out by phosphopantothenoylcysteine decarboxylase (PPCDC) (Daugherty et al. 2002). PPCDC is cytosolic and exists as a homotrimer, binding one FMN cofactor per subunit (Strauss et al. 2004). While a second isoform has been inferred from large-scale sequnceing studies, it lacks the protein's FMN-binding domain and would thus appear to be nonfunctional if it is expressed.

Literature References

PubMed ID	Title	Journal	Year
11923312	Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics Osterman, A, Farrell, M, Daugherty, M, de Crecy-Lagard, V, Scholle, M, Polanuyer, B, Lykidis, A	J Biol Chem	2002
15581364	Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent Begley, TP, Brand, LA, Zhai, H, Strauss, E, McLafferty, FW	Biochemistry	2004