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A tetrasaccharide linker sequence is required for GAG synthesis
Stable Identifier
R-HSA-1971475
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
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The biosynthesis of dermatan sulfate/chondroitin sulfate and heparin/heparan sulfate glycosaminoglycans (GAGs) starts with the formation of a tetrasaccharide linker sequence to the core protein. The first step is the addition of xylose to the hydroxy group of specific serine residues on the core protein. Subsequent additions of two galactoses and a glucuronide moiety completes the linker sequence. From here, the next hexosamine addition is critical as it determines which GAG is formed (Lamberg & Stoolmiller 1974, Pavao et al. 2006).
Literature References
PubMed ID
Title
Journal
Year
17239764
Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetics approaches
Mourão, PA
,
Pavão, MS
,
Vilela-Silva, AC
Adv Pharmacol
2006
4139221
Glycosaminoglycans. A biochemical and clinical review
Stoolmiller, AC
,
Lamberg, SI
J Invest Dermatol
1974
Participants
Events
XYLTs transfer Xyl to core protein
(Homo sapiens)
B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker
(Homo sapiens)
B3GALT6 transfers Gal to the tetrasaccharide linker
(Homo sapiens)
B3GAT dimers transfer GlcA to tetrasaccharide linker
(Homo sapiens)
B3GAT3 dimer transfers GlcA to tetrasaccharide linker
(Homo sapiens)
Participates
as an event of
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
Event Information
Go Biological Process
glycosaminoglycan metabolic process (0030203)
Orthologous Events
A tetrasaccharide linker sequence is required for GAG synthesis (Bos taurus)
A tetrasaccharide linker sequence is required for GAG synthesis (Caenorhabditis elegans)
A tetrasaccharide linker sequence is required for GAG synthesis (Canis familiaris)
A tetrasaccharide linker sequence is required for GAG synthesis (Danio rerio)
A tetrasaccharide linker sequence is required for GAG synthesis (Drosophila melanogaster)
A tetrasaccharide linker sequence is required for GAG synthesis (Gallus gallus)
A tetrasaccharide linker sequence is required for GAG synthesis (Mus musculus)
A tetrasaccharide linker sequence is required for GAG synthesis (Rattus norvegicus)
A tetrasaccharide linker sequence is required for GAG synthesis (Sus scrofa)
A tetrasaccharide linker sequence is required for GAG synthesis (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000930
Authored
Jassal, B (2011-11-04)
Reviewed
D'Eustachio, P (2012-03-28)
Created
Jassal, B (2011-11-04)
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