NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+

Stable Identifier
R-HSA-197198
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NAD(+) + ATP => ADP + NADP(+) + H(+), NAD+ is phosphorylated to NADP+
ReviewStatus
5/5
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NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+
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Cytosolic NAD+ kinase (NADK) catalyses the transfer of a phosphate group from ATP to NAD+, forming NADP+. This is the only way to generate NADP+ in all living organisms. NADK is tetrameric and requires one divalent metal such as Zn2+ per subunit to function correctly (Lerner et al. 2004).
Literature References
PubMed ID Title Journal Year
11594753 Structural and functional characterization of human NAD kinase

Lerner, F, Niere, M, Ludwig, A, Ziegler, M

Biochem Biophys Res Commun 2001
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Catalyst Activity

NAD+ kinase activity of NADK:Zn2+ tetramer [cytosol]

Physical Entity
NADK:Zn2+ tetramer [cytosol] (Homo sapiens)
Activity
NAD+ kinase activity (GO:0003951)
Orthologous Events
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Bos taurus)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Canis familiaris)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Danio rerio)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Dictyostelium discoideum)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Drosophila melanogaster)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Gallus gallus)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Mus musculus)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Rattus norvegicus)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Saccharomyces cerevisiae)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Schizosaccharomyces pombe)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Sus scrofa)
NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+ (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2007-05-02)
Reviewed
Hill, DP  (2025-06-02)
Created
Jassal, B  (2007-05-02)
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