Reactome | QPRT transfers PRIB to QUIN to form NAMN

QPRT transfers PRIB to QUIN to form NAMN

Stable Identifier

R-HSA-197268

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) => nicotinate beta-D-ribonucleotide + CO2 + diphosphate, A phospho-ribosyl group is added to quinolinate

ReviewStatus

4/5

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QPRT transfers PRIB to QUIN to form NAMN

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The enzyme, nicotinate nucleotide pyrophosphorylase, is specific for quinolinate. Its activity is strictly dependent on Mg2+ ions being present. A phosphoribosyl group is transferred to quinolinate to form nicotinate D-ribonucleotide. This reaction represents another rate-limiting step of the pathway from tryptophan to NAD+ (Fukuoka et al. 1998; Liu et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17868694	Structural and kinetic characterization of quinolinate phosphoribosyltransferase (hQPRTase) from homo sapiens Woznica, K, Naismith, JH, Liu, H, Botting, N, Crawford, A, Catton, G	J Mol Biol	2007
9473669	Characterization and functional expression of the cDNA encoding human brain quinolinate phosphoribosyltransferase Shibata, K, Fukuoka, SI, Nyaruhucha, CM	Biochim Biophys Acta	1998