NADSYN1 hexamer amidates NAAD to NAD+

Stable Identifier
R-HSA-197271
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Amidation of deamino-NAD+ to NAD+
ReviewStatus
5/5
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NAD synthases 1 and 2 (NADSYN1 and NADSYN2) catalyse the final step in the biosynthesis of NAD+, both in de novo synthesis and in the salvage pathway. The enzymes makes use of an amide donor in the reaction. NADSYNs exist as a homohexamers in the cytosol. The major difference between the two forms is that NADSYN1 appears to be glutamine-dependent whereas NADSYN2 is strictly ammonia-dependent (Hara et al. 2003).
Literature References
PubMed ID Title Journal Year
12547821 Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency.

Yamada, K, Terashima, M, Shimoyama, M, Osago, H, Hara, N, Tsuchiya, M

J Biol Chem 2003
Participants
Participates
Catalyst Activity

NAD+ synthase (glutamine-hydrolyzing) activity of NADSYN1 hexamer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Created
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