Reactome | NADSYN1 hexamer amidates NAAD to NAD+

NADSYN1 hexamer amidates NAAD to NAD+

Stable Identifier

R-HSA-197271

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

deamido-NAD(+) + L-glutamine + ATP + H2O => L-glutamate + AMP + diphosphate + NAD(+) + H(+), Amidation of deamino-NAD+ to NAD+

ReviewStatus

5/5

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Cytosolic hexameric NAD synthase 1 (NADSYN1) catalyses the final step in the biosynthesis of NAD+, both in de novo synthesis and in the salvage pathway. The enzymes makes use of an amide donor in the reaction (Hara et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12547821	Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. Hara, N, Yamada, K, Terashima, M, Osago, H, Shimoyama, M, Tsuchiya, M	J Biol Chem	2003