Reactome | NADSYN1 hexamer amidates NAAD to NAD+

NADSYN1 hexamer amidates NAAD to NAD+

Stable Identifier

R-HSA-197271

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Amidation of deamino-NAD+ to NAD+

ReviewStatus

5/5

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NAD synthases 1 and 2 (NADSYN1 and NADSYN2) catalyse the final step in the biosynthesis of NAD+, both in de novo synthesis and in the salvage pathway. The enzymes makes use of an amide donor in the reaction. NADSYNs exist as a homohexamers in the cytosol. The major difference between the two forms is that NADSYN1 appears to be glutamine-dependent whereas NADSYN2 is strictly ammonia-dependent (Hara et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12547821	Molecular identification of human glutamine- and ammonia-dependent NAD synthetases. Carbon-nitrogen hydrolase domain confers glutamine dependency. Yamada, K, Terashima, M, Shimoyama, M, Osago, H, Hara, N, Tsuchiya, M	J Biol Chem	2003