Reactome | HLA class II histocompatibility antigen, DQ [plasma membrane]

HLA class II histocompatibility antigen, DQ [plasma membrane]

Stable Identifier

R-HSA-197585

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

HA23_HUMAN, HLA-DQA1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01909 HLA-DQA1

Gene Names

HLA-DQA1

Chain

signal peptide:1-23, chain:24-254

Reference Genes

BioGPS Gene:3117 HLA-DQA1

COSMIC (genes):HLA-DQA1 HLA-DQA1

CTD Gene:3117 HLA-DQA1

dbSNP Gene:3117 HLA-DQA1

ENSEMBL:ENSG00000196735 HLA-DQA1

ENSEMBL:ENSG00000196735.13 HLA-DQA1

ENSEMBL:ENSG00000206305.12 HLA-DQA1

ENSEMBL:ENSG00000232062.9 HLA-DQA1

HGNC:4942 HLA-DQA1

KEGG Gene (Homo sapiens):3117 HLA-DQA1

Monarch:3117 HLA-DQA1

NCBI Gene:3117 HLA-DQA1

OMIM:146880 HLA-DQA1

UCSC:P01909 HLA-DQA1

Reference Transcript

RefSeq:NM_002122.3 HLA-DQA1

Other Identifiers

11724799_x_at

11750528_x_at

11753898_x_at

11756083_x_at

11758340_x_at

17028326

17038609

17041240

203290_PM_at

203290_at

212671_PM_s_at

212671_s_at

213831_PM_at

213831_at

2903223

2903224

2903227

2903229

2903231

2903233

2903234

2903235

2903236

2903259

2903265

2903266

3117

32773_at

8118556

8178199

8179489

A_23_P30900

A_24_P196827

A_24_P326084

A_24_P393230

A_33_P3293049

GE81121

GE890404

GO:0000139

GO:0002250

GO:0002376

GO:0002503

GO:0002504

GO:0005515

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006955

GO:0007155

GO:0010008

GO:0012507

GO:0016020

GO:0019882

GO:0019886

GO:0023026

GO:0030658

GO:0030666

GO:0030669

GO:0031410

GO:0032395

GO:0032588

GO:0042605

GO:0042613

GO:0043226

GO:0050870

GO:0060089

GO:0065003

GO:0098553

HMNXSV003000947

HMNXSV003054155

HMNXSV003055601

HMNXSV003056103

Hs.198253.1.A1_3p_a_at

Hs.198253.2.A1_3p_s_at

ILMN_1808405

K01160_s_at

M26041_s_at

M34996_s_at

PH_hs_0033085

TC6_cox_hap2000091.hg

TC6_qbl_hap6000082.hg

TC6_ssto_hap7000077.hg

g4504406_3p_at

p26545

p26546

Participates

as a member of

HLA II alpha chain [plasma membrane] (Homo sapiens)

Other forms of this molecule

HLA class II histocompatibility antigen, DQ [integral component of lumenal side of endoplasmic reticulum membrane]

HLA class II histocompatibility antigen, DQ [ER to Golgi transport vesicle membrane]

HLA class II histocompatibility antigen, DQ [Golgi membrane]

HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane]

HLA class II histocompatibility antigen, DQ [transport vesicle membrane]

HLA class II histocompatibility antigen, DQ [clathrin-coated endocytic vesicle membrane]

HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane]

HLA class II histocompatibility antigen, DQ [lysosomal membrane]

Inferred To

H2-Aa [plasma membrane] (Mus musculus)

LOC571282 [plasma membrane] (Danio rerio)

SLA-DQA1 [plasma membrane] (Sus scrofa)

si:dkey-33b17.1 [plasma membrane] (Danio rerio)

si:busm1-160c18.6 [plasma membrane] (Danio rerio)

BOLA-DQA1 [plasma membrane] (Bos taurus)

HLA class II histocompatibility antigen, DQ [plasma membrane] (Canis familiaris)

HLA class II histocompatibility antigen, DQ [plasma membrane] (Danio rerio)

HLA class II histocompatibility antigen, DQ [plasma membrane] (Sus scrofa)

hla-dqa1 [plasma membrane] (Xenopus tropicalis)

RT1-Ba [plasma membrane] (Rattus norvegicus)

Homologues of HLA class II histocompatibility antigen, DQ [plasma membrane] (Danio rerio)

Homologues of HLA class II histocompatibility antigen, DQ [plasma membrane] (Sus scrofa)

si:zfos-367g9.1 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_002113.2

OpenTargets

ENSG00000196735

HPA

ENSG00000196735-HLA-DQA1

GeneCards

P01909

Ensembl

ENSP00000378767, ENST00000383251, ENST00000444296, ENSP00000413237, ENSP00000364087, ENSP00000339398, ENSG00000232062, ENST00000418023, ENSG00000196735, ENST00000395363, ENST00000399678, ENSP00000387892, ENST00000343139, ENSP00000372738, ENST00000399675, ENSP00000382583, ENSP00000382586, ENSG00000206305, ENST00000374949

PRO

P01909

Pharos - Targets

P01909

Orphanet

16829

PDB

6U3N, 5KSA, 1UVQ, 5KSU, 4OZG, 6U3M, 7SG2, 4OZH, 7SG1, 5KSV, 5KSB, 1S9V, 6MFG, 6XP6, 6MFF, 2NNA, 4GG6, 4OZI, 1JK8, 7SG0, 4OZF

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.674	4

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