Reactome | IL1R2 [plasma membrane]

IL1R2 [plasma membrane]

Stable Identifier

R-HSA-197598

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Interleukin-1 receptor, type II, IL1S_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P27930 IL1R2

Gene Names

IL1R2, IL1RB

Chain

signal peptide:1-13, chain:14-398, chain:14-

Reference Genes

BioGPS Gene:7850 IL1R2

COSMIC (genes):IL1R2 IL1R2

CTD Gene:7850 IL1R2

dbSNP Gene:7850 IL1R2

ENSEMBL:ENSG00000115590 IL1R2

ENSEMBL_homo_sapiens_GENE:ENSG00000115590.14 IL1R2

HGNC:5994 IL1R2

KEGG Gene (Homo sapiens):7850 IL1R2

Monarch:7850 IL1R2

NCBI Gene:7850 IL1R2

OMIM:147811 IL1R2

UCSC:P27930 IL1R2

Reference Transcript

Other Identifiers

11728500_a_at

16883624

205403_PM_at

205403_at

211372_PM_s_at

211372_s_at

2496908

2496911

2496917

2496918

2496919

2496920

2496921

2496925

2496927

2496931

2496936

2496937

2496938

2496940

2496941

2496942

7850

8043981

998_s_at

A_23_P79398

A_24_P63019

GE59851

GO:0002376

GO:0004908

GO:0004910

GO:0005515

GO:0005576

GO:0005737

GO:0005886

GO:0006954

GO:0006955

GO:0010955

GO:0016020

GO:0016485

GO:0019221

GO:0019966

GO:0023052

GO:0032690

GO:0051604

GO:0060089

GO:1900016

GO:2000660

HMNXSV003047779

HMNXSV003048623

ILMN_1758371

ILMN_1772131

ILMN_2251766

PH_hs_0002227

TC02000619.hg

X59770_at

g1488065_3p_a_at

Participates

as a member of

as a component of

IL1B,Myr82K-Myr83K-IL1A:IL1R2 [plasma membrane] (Homo sapiens)

as an input of

Interleukin-1 receptor type 2 binds Interleukin 1 (Homo sapiens)

Inferred To

il1r2 [plasma membrane] (Xenopus tropicalis)

Il1r2 [plasma membrane] (Mus musculus)

Il1r2 [plasma membrane] (Rattus norvegicus)

IL1R2 [plasma membrane] (Bos taurus)

IL1R2 [plasma membrane] (Canis familiaris)

IL1R2 [plasma membrane] (Gallus gallus)

IL1R2 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

XP_006712797.1, XP_011510106.1, NP_001248348.1, NP_004624.1

Guide to Pharmacology - Targets

2319

OpenTargets

ENSG00000115590

GeneCards

P27930

HPA

ENSG00000115590-IL1R2

Ensembl

ENSP00000414611, ENSG00000115590, ENSP00000377066, ENST00000332549, ENSP00000330959, ENST00000441002, ENST00000393414

PRO

P27930

Pharos - Targets

P27930

PDB

3O4O

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01583 IL1A	4	Myr82K-Myr83K-IL1A [extracellular region] (R-HSA-445746) IL1A(1-112) [cytosol] (R-HSA-449059) 2xMyri-IL1A [cytosol] (R-HSA-449054) IL1A(1-271) [cytosol] (R-HSA-449042)	0.661	4
UniProt:Q8IYI6 EXOC8	2	EXOC8 [plasma membrane] (R-HSA-264948) EXOC8 [cytosol] (R-HSA-5623388)	0.527	4
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.527	4
UniProt:Q8TAG9 EXOC6	2	EXOC6 [plasma membrane] (R-HSA-265041) EXOC6 [cytosol] (R-HSA-5623384)	0.527	4
UniProt:O60645 EXOC3	2	EXOC3 [secretory granule membrane] (R-HSA-2872286) EXOC3 [cytosol] (R-HSA-5623379)	0.527	4
UniProt:Q96DE0 NUDT16	1	NUDT16 [nucleoplasm] (R-HSA-2509807)	0.527	4
UniProt:Q8TAD4 SLC30A5	2	SLC30A5 [Golgi membrane] (R-HSA-9817559) SLC30A5 [secretory granule membrane] (R-HSA-437105)	0.527	2
UniProt:Q96ER9 MITOK			0.527	3
UniProt:Q96KP1 EXOC2	2	EXOC2 [plasma membrane] (R-HSA-264887) EXOC2 [cytosol] (R-HSA-5623376)	0.527	4
UniProt:O43181 NDUFS4	1	NDUFS4 [mitochondrial inner membrane] (R-HSA-163946)	0.527	3
UniProt:Q96A65 EXOC4	2	EXOC4 [plasma membrane] (R-HSA-264989) EXOC4 [cytosol] (R-HSA-5623381)	0.527	4
UniProt:Q8N5K1 CISD2			0.527	2
UniProt:Q86WA8 LONP2	3	LONP2 [cytosol] (R-HSA-391291) LONP2 [peroxisomal matrix] (R-HSA-9033144) LONP2 [cytosol] (R-HSA-8963025)	0.527	3
UniProt:Q96DX4 RSPRY			0.527	3
UniProt:Q9UI09 NDUFA12	1	NDUFA12 [mitochondrial inner membrane] (R-HSA-59864)	0.527	3
UniProt:Q5JTY5 ZNG1C			0.527	2
UniProt:O94955 RHOBTB3	1	RHOBTB3 [trans-Golgi network membrane] (R-HSA-6813908)	0.527	2
UniProt:Q8TCG1 CIP2A			0.527	2
UniProt:Q9BTT6 LRRC1	1	LRRC1 [cytosol] (R-HSA-9715190)	0.527	3
UniProt:Q9NPH3 IL1RAP			0.524	2

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