Reactome | CD22 [plasma membrane]

CD22 [plasma membrane]

Stable Identifier

R-HSA-197703

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

B-cell receptor CD22 precursor, CD22_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P20273 CD22

Gene Names

CD22, SIGLEC2

Chain

signal peptide:1-19, chain:20-847

Reference Genes

BioGPS Gene:933 CD22

COSMIC (genes):CD22 CD22

CTD Gene:933 CD22

dbSNP Gene:933 CD22

ENSEMBL:ENSG00000012124 CD22

HGNC:1643 CD22

KEGG:hsa:933 CD22

Monarch:933 CD22

NCBI Gene:933 CD22

OMIM:107266 CD22

UCSC:P20273 CD22

Reference Transcript

Other Identifiers

11726290_a_at

11754830_a_at

16860992

204581_PM_at

204581_at

217422_3p_s_at

217422_PM_s_at

217422_s_at

220674_3p_at

220674_PM_at

220674_at

3830344

3830345

3830347

3830349

3830350

3830352

3830354

3830355

3830356

3830357

3830358

3830360

3830361

3830362

3830363

3830364

3830365

3830366

3830367

3830368

3830369

3830370

3830371

3830372

3830373

3830374

3830375

3830376

3830377

3830378

3830379

3830380

3830381

3830382

3830384

3830385

3830388

3830389

3830390

3830391

3830392

3830393

3830394

3830395

3830396

3830398

3830401

3830405

3830407

3830409

3830411

38521_PM_at

38521_at

38522_s_at

4853636C_3p_s_at

52277_at

57449_at

67629_at

8027837

933

A_14_P128902

A_14_P131478

A_23_P209055

A_24_P254106

GE81067

GO:0001791

GO:0002376

GO:0002638

GO:0005102

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005886

GO:0007155

GO:0009897

GO:0009986

GO:0016020

GO:0019903

GO:0030100

GO:0030246

GO:0030888

GO:0031410

GO:0032809

GO:0033691

GO:0042113

GO:0042609

GO:0043226

GO:0050776

GO:0050849

GO:0050859

GO:0055037

GO:0070062

HMNXSV003006655

HMNXSV003039199

HMNXSV003054858

Hs.171763.1.S1_3p_a_at

Hs.171763.1.S1_3p_s_at

ILMN_1792075

PH_hs_0023308

TC19002611.hg

X59350_at

g13376383_3p_at

g4502650_3p_at

g4502650_3p_s_at

p8695

Participates

as a candidate of

SIGLEC [plasma membrane] (Homo sapiens)

as a component of

CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)

as an input of

CD22 binds B-cell receptor (Homo sapiens)

Other forms of this molecule

p-Y762,807,822-CD22 [plasma membrane]

NAc-CD22 [plasma membrane]

Inferred To

cd22 [plasma membrane] (Xenopus tropicalis)

MAG [plasma membrane] (Canis familiaris)

Cd22 [plasma membrane] (Rattus norvegicus)

CD22 [plasma membrane] (Bos taurus)

CD22 [plasma membrane] (Mus musculus)

CD22 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001265346.1, NP_001172030.1, NP_001172028.1, NP_001762.2, NP_001172029.1

Guide to Pharmacology - Targets

2786

OpenTargets

ENSG00000012124

ENSEMBL

ENSP00000469984, ENST00000419549, ENST00000536635, ENSP00000442279, ENST00000544992, ENST00000085219, ENSP00000339349, ENST00000341773, ENSP00000441237, ENSP00000085219, ENST00000594250, ENSP00000403822

ZINC - Substances

CD22_HUMAN

ZINC target

P20273

PRO

P20273

GlyGen

P20273

PDB

5VKJ, 7O52, 5VL3, 5VKM

HPA

ENSG00000012124-CD22

Pharos - Targets

P20273

ZINC - Predictions - Purchasable

CD22_HUMAN

HMDB Protein

HMDBP14330

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43405 SYK	6	p-Y-SYK [cytosol] (R-HSA-9705732) p-Y-SYK [plasma membrane] (R-HSA-429432) SYK [plasma membrane] (R-HSA-139844) p-6Y-SYK [cytosol] (R-HSA-1861712) p-Y348-SYK [cytosol] (R-HSA-437953) SYK [cytosol] (R-HSA-58268)	0.623	4
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.499	4
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.499	2
UniProt:P07948 LYN	7	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903)	0.499	2