Reactome | KIR3DL2 [plasma membrane]

KIR3DL2 [plasma membrane]

Stable Identifier

R-HSA-197713

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Killer cell immunoglobulin-like receptor 3DL2 precursor, K3L2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O75051 PLXNA2

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External Reference Information

External Reference

UniProt:P43630 KIR3DL2

Gene Names

KIR3DL2, CD158K, NKAT4

Chain

signal peptide:1-21, chain:22-455

Reference Genes

BioGPS Gene:3812 KIR3DL2

COSMIC (genes):KIR3DL2 KIR3DL2

CTD Gene:3812 KIR3DL2

dbSNP Gene:3812 KIR3DL2

ENSEMBL:ENSG00000240403 KIR3DL2

HGNC:6339 KIR3DL2

KEGG:hsa:3812 KIR3DL2

Monarch:3812 KIR3DL2

NCBI Gene:3812 KIR3DL2

OMIM:604947 KIR3DL2

UCSC:P43630 KIR3DL2

Reference Transcript

Other Identifiers

11755085_x_at

16865530

16876286

16876297

207313_PM_x_at

207313_x_at

207314_PM_x_at

207314_x_at

211688_PM_x_at

211688_x_at

216907_PM_x_at

216907_x_at

36735_f_at

3812

3841717

3841721

3841724

3841731

3841734

3841739

3841740

3841743

3841749

3841755

3841757

3841760

3841774

3841778

3841783

3841785

3841808

3841814

3841816

3841822

3841823

3841824

3841825

3841826

3841827

3841828

3841829

3841830

3841831

3841833

3841834

3841835

3841836

3841837

3841841

3841843

3841846

3841858

4052958

4052965

4052975

4052978

4052992

4053003

4053005

4053010

4053021

4053024

4053042

4053045

4053047

4053058

4053073

4053075

4053076

4053077

4053078

4053079

4053080

4053082

8031328

A_23_P101636

A_33_P3233010

GE61442

GO:0002764

GO:0005515

GO:0005886

GO:0006968

GO:0016020

GO:0023029

HMNXSV003010648

Hs.158310.0.S1_3p_x_at

PH_hs_0028918

PH_hs_0034845

TC19002658.hg

TC19_gl000209_random000004.hg

g1217718_3p_x_at

g5803051_3p_x_at

Participates

as a component of

HLA-A3 interacting with KIR3DL2 [plasma membrane] (Homo sapiens)

as an input of

KIR3DL2 interacting with HLA-A3 (Homo sapiens)

Inferred To

KIR2DL1 [plasma membrane] (Bos taurus)

KIR2DL1 [plasma membrane] (Sus scrofa)

KIR3DL2 [plasma membrane] (Bos taurus)

KIR3DL2 [plasma membrane] (Xenopus tropicalis)

Kir3dl2 [plasma membrane] (Mus musculus)

KIR2DS1 [plasma membrane] (Bos taurus)

Homologues of KIR3DL2 [plasma membrane] (Bos taurus)

Homologues of KIR3DL2 [plasma membrane] (Mus musculus)

Homologues of KIR3DL2 [plasma membrane] (Xenopus tropicalis)

Kir3dl1 [plasma membrane] (Mus musculus)

Kir3dl1 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_006728.2, NP_001229796.1

Guide to Pharmacology - Targets

3067

OpenTargets

ENSG00000240403

ENSEMBL

ENSG00000275083, ENSP00000325525, ENSP00000478251, ENST00000617957, ENSP00000270442, ENSG00000278809, ENST00000622453, ENSG00000275416, ENSP00000482589, ENST00000611859, ENST00000622579, ENSG00000278442, ENSG00000240403, ENST00000621155, ENST00000622024, ENSP00000481662, ENSP00000479772, ENSP00000477519, ENST00000614753, ENSG00000275566, ENST00000617666, ENSP00000477516, ENSG00000278474, ENSG00000274722, ENSP00000482110, ENSG00000277181, ENST00000613610, ENSP00000481579, ENSP00000482565, ENSG00000276004, ENSP00000481871, ENST00000620817, ENST00000613612, ENST00000270442, ENST00000617354, ENSP00000479903, ENSG00000278361, ENSP00000479425, ENSG00000276739, ENSP00000482301, ENSP00000480578, ENSP00000482655, ENSP00000481209, ENSG00000275626, ENSG00000276357, ENST00000326321, ENSP00000481306, ENST00000611608, ENST00000611628, ENST00000612138, ENSP00000479299, ENST00000619683, ENST00000618273, ENST00000617481

GeneCards

KIR3DL2

HPA

ENSG00000240403-KIR3DL2

PRO

P43630

Pharos - Targets

P43630

GlyGen

P43630

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30511 HLA-F	7	HLA class I histocompatibility antigen, alpha chain F precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983093) HLA class I histocompatibility antigen, alpha chain F precursor [early endosome membrane] (R-HSA-1236895) HLA class I histocompatibility antigen, alpha chain F precursor [plasma membrane] (R-HSA-197572) HLA class I histocompatibility antigen, alpha chain F precursor [phagocytic vesicle membrane] (R-HSA-1236887) HLA class I histocompatibility antigen, alpha chain F precursor [recycling endosome membrane] (R-HSA-8863878) HLA class I histocompatibility antigen, alpha chain F precursor [ER to Golgi transport vesicle membrane] (R-HSA-983375) HLA class I histocompatibility antigen, alpha chain F precursor [Golgi membrane] (R-HSA-983394)	0.715	6
UniProt:Q6NUQ4 TM214			0.527	2
UniProt:Q8N5K1 CISD2			0.527	2
UniProt:A6NJ78 MET15			0.527	2
UniProt:Q9NRY5 FAM114A2	2	FAM114A2(1-327)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802525) FAM114A2(1-327)-BRAF(439-766) fusion [cytosol] (R-HSA-6802321)	0.527	2
UniProt:P50479 PDLI4			0.527	2
UniProt:P26440 IVD	16	IVD [mitochondrial matrix] (R-HSA-70729) R398Q IVD [mitochondrial matrix] (R-HSA-9914799) I379T IVD [mitochondrial matrix] (R-HSA-9914797) Y403N IVD [mitochondrial matrix] (R-HSA-9914808) D72N IVD [mitochondrial matrix] (R-HSA-9914807) V374A IVD [mitochondrial matrix] (R-HSA-9914806) R53P IVD [mitochondrial matrix] (R-HSA-9914805) G123R IVD [mitochondrial matrix] (R-HSA-9914804) R395C IVD [mitochondrial matrix] (R-HSA-9914803) M332T IVD [mitochondrial matrix] (R-HSA-9914802) A314V IVD [mitochondrial matrix] (R-HSA-9914801) L45P IVD [mitochondrial matrix] (R-HSA-9914800) R414L IVD [mitochondrial matrix] (R-HSA-9914796) T239I IVD [mitochondrial matrix] (R-HSA-9914795) R340Q IVD [mitochondrial matrix] (R-HSA-9914810) C360R IVD [mitochondrial matrix] (R-HSA-9914809)	0.527	2
UniProt:Q5K4L6 SLC27A3	1	SLC27A3 [mitochondrial matrix] (R-HSA-5216184)	0.527	2
UniProt:O75051 PLXNA2	2	PLXNA2 [plasma membrane] (R-HSA-396934) p-Y-PLXNA2 [plasma membrane] (R-HSA-419607)	0.527	2
UniProt:Q6PIJ6 FBX38			0.527	2
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.527	2
UniProt:Q9NUQ7 UFSP2			0.527	2
UniProt:P04578 env	7	Surface protein gp120 [viral envelope] (R-HIV-171211) ENV [viral envelope] (R-HIV-173439) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	2

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