E3 ubiquitin ligase NEDD4 mediates ubiquitination of ERBB4 JM-A CYT-1 intracellular domain s80 (ERBB4jmAcyt1s80) produced by ERBB4 cleavage. This induces degradation of ERBB4jmAcyt1s80, and decreases the amount of ERBB4jmAcyt1s80 that reaches the nucleus (Zeng et al. 2009).
Harris, RC, Zeng, F, Xu, J
ubiquitin-protein transferase activity of ERBB4jmAcyt1s80:NEDD4 [cytosol]
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