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CD47 [plasma membrane]
Stable Identifier
R-HSA-197736
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Leukocyte surface antigen CD47, CD47_HUMAN, Integrin-associated protein, IAP
Icon
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Signal regulatory protein family interactions (Homo sapiens)
Phosphorylation of ITIM motif in SIRP alpha (Homo sapiens)
SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
SIRP alpha binds CD47 (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
SIRP gamma binds CD47 (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
SIRP gamma:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
p-4Y-SIRPA:CD47 binds GRB2-1 (Homo sapiens)
p-Y428,Y452,Y469,Y495-SIRPA:CD47:GRB2-1 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
p-4Y-SIRPA:CD47 binds PTK2B (Homo sapiens)
p-Y428,Y452,Y469,Y495-SIRPA:CD47:PTK2B [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
p-4Y-SIRPA:CD47 binds SKAP2 (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47:SKAP2 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
p-4Y-SIRPA:CD47:SKAP2 binds FYB (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47:SKAP2 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496y-SIRPA:CD47:SKAP2:FYB [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47:SKAP2 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47 (Homo sapiens)
COMP pentamer:Integrin alpha5beta1, Integrin alphaVbeta3, CD47 [plasma membrane] (Homo sapiens)
Integrin alpha5beta1, Integrin alphaVbeta3, CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
Integrin alpha5beta1, Integrin alphaVbeta3, CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
CD47 binds SIRP (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
CD47-binding SIRPs:CD47 [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
CD47 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08722 CD47
Gene Names
CD47, MER6
Chain
signal peptide:1-18, chain:19-323
Reference Genes
BioGPS Gene:961 CD47
COSMIC (genes):CD47 CD47
CTD Gene:961 CD47
dbSNP Gene:961 CD47
ENSEMBL:ENSG00000196776 CD47
ENSEMBL_homo_sapiens_GENE:ENSG00000196776.17 CD47
HGNC:1682 CD47
KEGG Gene (Homo sapiens):961 CD47
Monarch:961 CD47
NCBI Gene:961 CD47
OMIM:601028 CD47
UCSC:Q08722 CD47
Reference Transcript
RefSeq:NM_198793.2 CD47
RefSeq:NM_001777.3 CD47
Other Identifiers
11735329_a_at
11743347_a_at
11743348_a_at
16957095
211075_PM_s_at
211075_s_at
213055_PM_at
213055_at
213857_PM_s_at
213857_s_at
226016_PM_at
226016_at
227259_3p_at
227259_PM_at
227259_at
2687769
2687770
2687771
2687772
2687773
2687774
2687775
2687776
2687780
2687783
2687789
2687790
2687791
2687792
2687793
2687798
2687800
2687801
2687806
2687807
2687808
37890_at
54922_at
61356_at
8089299
87790_at
961
A_23_P6935
GE56946
GE59958
GO:0001525
GO:0002376
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006915
GO:0006954
GO:0007010
GO:0007155
GO:0007229
GO:0008284
GO:0009986
GO:0012501
GO:0016020
GO:0016192
GO:0016477
GO:0022409
GO:0023052
GO:0031410
GO:0032649
GO:0032653
GO:0032655
GO:0032675
GO:0032680
GO:0034113
GO:0035579
GO:0043226
GO:0045428
GO:0048856
GO:0048870
GO:0050729
GO:0050765
GO:0050766
GO:0050870
GO:0051496
GO:0060089
GO:0060368
GO:0070053
GO:0070062
GO:0070821
GO:0071346
GO:0071347
GO:0071349
GO:0086080
GO:0098542
GO:0098609
GO:0098631
GO:0098632
GO:1904669
GO:2000439
HMNXSV003012845
Hs.288856.4.A1_3p_at
Hs.288856.4.A1_3p_s_at
Hs.288856.4.A1_3p_x_at
Hs.76728.0.S1_3p_at
Hs.82685.1.S1_3p_s_at
ILMN_1771333
ILMN_2356991
PH_hs_0027478
TC03001629.hg
X69398_at
Z25521_s_at
Participates
as a component of
SIRP gamma:CD47 [plasma membrane] (Homo sapiens)
SIRPA:CD47 [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47 [plasma membrane] (Homo sapiens)
CD47-binding SIRPs:CD47 [plasma membrane] (Homo sapiens)
as an input of
SIRP gamma binds CD47 (Homo sapiens)
SIRP alpha binds CD47 (Homo sapiens)
CD47 binds SIRP (Homo sapiens)
as a member of
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
Integrin alpha5beta1, Integrin alphaVbeta3, CD47 [plasma membrane] (Homo sapiens)
Other forms of this molecule
CD47 [specific granule membrane]
CD47 [tertiary granule membrane]
Inferred To
CD47 [plasma membrane]
(Bos taurus)
CD47 [plasma membrane]
(Canis familiaris)
CD47 [plasma membrane]
(Gallus gallus)
CD47 [plasma membrane]
(Sus scrofa)
Cd47 [plasma membrane]
(Mus musculus)
Cd47 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_942088.1
,
NP_001768.1
Guide to Pharmacology - Targets
2943
OpenTargets
ENSG00000196776
GeneCards
Q08722
HPA
ENSG00000196776-CD47
Ensembl
ENSG00000196776
,
ENST00000355354
,
ENSP00000355361
,
ENST00000361309
,
ENSP00000347512
PRO
Q08722
Pharos - Targets
Q08722
PDB
5TZU
,
7MYZ
,
7XJF
,
7YGG
,
5TZT
,
4CMM
,
4KJY
,
5TZ2
,
2JJS
,
2JJT
,
7WN8
,
2VSC
,
5IWL
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N205 SYNE4
0.556
3
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