Reactome | NCR1 [plasma membrane]

NCR1 [plasma membrane]

Stable Identifier

R-HSA-197739

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Natural cytotoxicity triggering receptor 1 precursor, NCT1_HUMAN

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - viral HA binds NCRI (Homo sapiens)
      - NCR1:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        NCR1 [plasma membrane] (Homo sapiens)
      - NCR1:FCRG1A:CD3Z dimer:Hemagglutinin [plasma membrane] (Homo sapiens)
        
        NCR1:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)
        
        NCR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O76036 NCR1

Gene Names

NCR1, LY94

Chain

signal peptide:1-21, chain:22-304

Reference Genes

BioGPS Gene:9437 NCR1

COSMIC (genes):NCR1 NCR1

CTD Gene:9437 NCR1

dbSNP Gene:9437 NCR1

ENSEMBL:ENSG00000189430 NCR1

ENSEMBL_homo_sapiens_GENE:ENSG00000189430.13 NCR1

ENSEMBL_homo_sapiens_GENE:ENSG00000273535.4 NCR1

ENSEMBL_homo_sapiens_GENE:ENSG00000275156.4 NCR1

ENSEMBL_homo_sapiens_GENE:ENSG00000278362.4 NCR1

HGNC:6731 NCR1

KEGG Gene (Homo sapiens):9437 NCR1

Monarch:9437 NCR1

NCBI Gene:9437 NCR1

OMIM:604530 NCR1

UCSC:O76036 NCR1

Reference Transcript

Other Identifiers

11738679_a_at

11759971_at

16865554

207860_PM_at

207860_at

217088_PM_s_at

217088_s_at

217095_PM_x_at

217095_x_at

34039_at

34040_s_at

3841882

3841883

3841884

3841885

3841886

3841887

3841890

3841891

3841892

3841893

8031387

9437

A_23_P108042

A_33_P3329063

A_33_P3571824

GE80817

GO:0002376

GO:0005515

GO:0005634

GO:0005694

GO:0005886

GO:0006968

GO:0007165

GO:0016020

GO:0016514

GO:0023052

GO:0030101

GO:0042269

GO:0043226

GO:0098542

HMNXSV003000712

HMNXSV003042382

Hs.97084.1.S1_3p_a_at

ILMN_1750761

PH_hs_0005258

TC19000886.hg

g4758691_3p_at

Participates

as a component of

NCR1:FCRG1A:CD3Z dimer [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001229286.1, NP_004820.2, NP_001138930.2, NP_001138929.2, NP_001229285.1

OpenTargets

ENSG00000189430

GeneCards

O76036

HPA

ENSG00000189430-NCR1

Ensembl

ENSG00000273535, ENSP00000482092, ENST00000617154, ENSP00000483028, ENST00000611098, ENSP00000482536, ENSP00000484831, ENSP00000483723, ENSP00000484377, ENSG00000275156, ENSP00000482423, ENST00000621059, ENSG00000189430, ENSP00000481540, ENSP00000479222, ENSP00000480145, ENSP00000344358, ENST00000621652, ENSP00000478507, ENSP00000477625, ENSG00000278362, ENSP00000349972, ENST00000617784, ENST00000611105, ENST00000615622, ENST00000612896, ENST00000611942, ENST00000618973, ENST00000620296, ENSP00000481692, ENSP00000481971, ENST00000612239, ENST00000610753, ENST00000613556, ENST00000610621, ENST00000612645, ENSP00000483452, ENSP00000484221, ENSP00000484520, ENSP00000483611, ENST00000619077, ENSP00000484067, ENST00000619451, ENST00000613135, ENST00000350790, ENST00000357397

PRO

O76036

Pharos - Targets

O76036

PDB

1OLL, 6IAP, 1P6F

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.611	3

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