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SEMA4D [plasma membrane]
Stable Identifier
R-HSA-197744
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Semaphorin 4D
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Other semaphorin interactions (Homo sapiens)
SEMA4D interacts with CD45 (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
SEMA4D:PTPRC [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
SEMA4D interacts with CD72 (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
SEMA4D:CD72 [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
Activation of Rho by LARG and PDZ-RhoGEF (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
LARG and PDZ-RhoGEF binds to Plexin-B1 (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1:ARHGEF11,ARHGEF12 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1:RND1 [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
SEMA4D interacts with Plexin-B1:ErbB2 (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
SEMA4D:ERBB2:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
Sema4D mediated inhibition of cell attachment and migration (Homo sapiens)
Active Rac1 interacts with Plexin-B1:Sema4D (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
Sema4D:pPlexin-B1:Met:RAC1-GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
Inactivation of Rho-GTP by p190RhoGAP (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
Rnd1 interacts with Plexin-B1:Sema4D (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
SEMA4D interacts with Plexin-B1:Met (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
p190RhoGAP binds Plexin-B1 (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP:ARHGAP35 [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1:RND1:GTP [plasma membrane] (Homo sapiens)
SEMA4D:MET:p-Y-PLXNB1 [plasma membrane] (Homo sapiens)
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92854 SEMA4D
Gene Names
SEMA4D, C9orf164, CD100, SEMAJ
Chain
signal peptide:1-21, chain:22-862
Reference Genes
BioGPS Gene:10507 SEMA4D
COSMIC (genes):SEMA4D SEMA4D
CTD Gene:10507 SEMA4D
dbSNP Gene:10507 SEMA4D
ENSEMBL:ENSG00000187764 SEMA4D
HGNC:10732 SEMA4D
KEGG:hsa:10507 SEMA4D
Monarch:10507 SEMA4D
NCBI Gene:10507 SEMA4D
OMIM:601866 SEMA4D
UCSC:Q92854 SEMA4D
Reference Transcript
RefSeq:XM_017014196.1 SEMA4D
RefSeq:NM_006378.3 SEMA4D
RefSeq:XM_011518125.1 SEMA4D
RefSeq:NM_001142287.1 SEMA4D
RefSeq:XM_017014193.1 SEMA4D
RefSeq:XM_011518131.2 SEMA4D
RefSeq:XM_011518133.2 SEMA4D
RefSeq:XM_011518127.2 SEMA4D
RefSeq:XM_017014198.1 SEMA4D
RefSeq:XM_005251654.3 SEMA4D
RefSeq:XM_017014194.1 SEMA4D
RefSeq:XM_011518129.1 SEMA4D
RefSeq:XM_011518128.2 SEMA4D
RefSeq:XM_017014197.1 SEMA4D
RefSeq:XM_017014195.1 SEMA4D
RefSeq:XM_011518123.2 SEMA4D
RefSeq:XM_011518134.2 SEMA4D
RefSeq:XM_011518124.2 SEMA4D
RefSeq:XM_011518130.2 SEMA4D
Other Identifiers
10507
11730004_a_at
11730005_a_at
11745691_a_at
11752178_a_at
11755804_a_at
17095587
203528_PM_at
203528_at
228891_PM_at
228891_at
3213944
3213945
3213946
3213968
3213970
3213972
3213974
3213976
3213977
3213978
3213980
3213982
3213984
3213986
3213988
3213990
3213992
3213994
3214002
3214004
3214006
3254695
3515452
4050229
4050230
4051227
4051228
4051229
4051230
4051231
4051232
4051233
4051234
4051235
4051236
4051237
4051238
4051239
4051240
4051241
4051242
4051243
4051255
4051257
4051259
4051260
4051261
4051262
4051263
4051264
4051265
4051266
4051267
4051268
4051269
4051270
4051271
4051272
4051273
4051274
4051275
4051276
4051277
4051284
4051285
4051286
4051287
4051289
4051290
4051291
4051293
4051294
4051295
58205_at
68331_at
78158_at
8162231
8162236
A_24_P229055
A_24_P261169
A_33_P3697530
GE59275
GO:0000122
GO:0001755
GO:0001934
GO:0002116
GO:0002376
GO:0004888
GO:0005102
GO:0005515
GO:0005615
GO:0005886
GO:0006355
GO:0006955
GO:0007155
GO:0007162
GO:0007165
GO:0007399
GO:0007409
GO:0007411
GO:0008360
GO:0030154
GO:0030215
GO:0030335
GO:0031344
GO:0035025
GO:0038023
GO:0042802
GO:0043066
GO:0043547
GO:0043931
GO:0045211
GO:0045499
GO:0045668
GO:0048018
GO:0048672
GO:0048731
GO:0048814
GO:0048856
GO:0048870
GO:0050731
GO:0050732
GO:0050772
GO:0050919
GO:0051897
GO:0051963
GO:0060089
GO:0061430
GO:0070486
GO:0071526
GO:0098772
GO:0098982
GO:1905704
HMNXSV003023987
HMNXSV003040264
HMNXSV003051269
Hs.13701.0.A1_3p_at
ILMN_1687533
ILMN_1733221
PH_hs_0026607
PH_hs_0030788
TC09001313.hg
U60800_at
g5454049_3p_at
Participates
as a component of
SEMA4D dimer [plasma membrane] (Homo sapiens)
SEMA4D:CD72 [plasma membrane] (Homo sapiens)
SEMA4D:PTPRC [plasma membrane] (Homo sapiens)
as an input of
SEMA4D interacts with CD72 (Homo sapiens)
SEMA4D interacts with CD45 (Homo sapiens)
Inferred To
Sema2b [plasma membrane]
(Drosophila melanogaster)
Ghost homologue of SEMA4D [plasma membrane]
(Danio rerio)
SEMA4D [plasma membrane]
(Bos taurus)
SEMA4D [plasma membrane]
(Canis familiaris)
SEMA4D [plasma membrane]
(Gallus gallus)
SEMA4D [plasma membrane]
(Sus scrofa)
mab-20 [plasma membrane]
(Caenorhabditis elegans)
smp-1 [plasma membrane]
(Caenorhabditis elegans)
Sema1b [plasma membrane]
(Drosophila melanogaster)
Sema4d [plasma membrane]
(Mus musculus)
Sema4d [plasma membrane]
(Rattus norvegicus)
sema4d [plasma membrane]
(Xenopus tropicalis)
Sema1a [plasma membrane]
(Drosophila melanogaster)
Homologues of SEMA4D [plasma membrane]
(Caenorhabditis elegans)
Homologues of SEMA4D [plasma membrane]
(Drosophila melanogaster)
Sema2a [plasma membrane]
(Drosophila melanogaster)
smp-2 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_016869686.1
,
XP_016869687.1
,
XP_016869684.1
,
XP_016869685.1
,
XP_005251711.1
,
XP_011516426.1
,
NP_001135759.1
,
XP_011516427.1
,
XP_011516435.1
,
XP_011516425.1
,
XP_016869683.1
,
XP_016869682.1
,
XP_011516429.1
,
XP_011516431.1
,
XP_011516430.1
,
XP_011516432.1
,
XP_011516436.1
,
XP_011516433.1
,
NP_006369.3
Guide to Pharmacology - Targets
2883
OpenTargets
ENSG00000187764
ENSEMBL
ENSP00000405102
,
ENSP00000348822
,
ENST00000438547
,
ENSP00000391733
,
ENST00000455551
,
ENST00000422704
,
ENST00000420987
,
ENSP00000388768
,
ENST00000450295
,
ENSP00000416523
,
ENST00000339861
,
ENSP00000344923
,
ENSP00000411981
,
ENST00000356444
HPA
ENSG00000187764-SEMA4D
PRO
Q92854
Pharos - Targets
Q92854
GlyGen
Q92854
PDB
3OL2
,
1OLZ
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
3
UniProt:Q92187 ST8SIA4
1
ST8SIA4 [Golgi membrane]
(R-HSA-422390)
0.527
2
UniProt:O95968 SG1D1
0.527
2
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.488
2
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