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TEK [plasma membrane]
Stable Identifier
R-HSA-197755
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Angiopoietin 1 receptor precursor, TIE2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P62158 CALM
Expand all
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Tie2 Signaling (Homo sapiens)
Interaction of Tie2 and Ang4 (Homo sapiens)
TEK [plasma membrane] (Homo sapiens)
Interaction of Tie2 with Ang1 (Homo sapiens)
TEK [plasma membrane] (Homo sapiens)
Interaction of Tie2 with Ang2 (Homo sapiens)
TEK [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q02763 TEK
Gene Names
TEK, TIE2, VMCM, VMCM1
Chain
signal peptide:1-22, chain:23-1124
Reference Genes
BioGPS Gene:7010 TEK
COSMIC (genes):TEK TEK
CTD Gene:7010 TEK
dbSNP Gene:7010 TEK
ENSEMBL:ENSG00000120156 TEK
ENSEMBL:ENSG00000120156.22 TEK
HGNC:11724 TEK
KEGG Gene (Homo sapiens):7010 TEK
Monarch:7010 TEK
NCBI Gene:7010 TEK
OMIM:600221 TEK
UCSC:Q02763 TEK
Reference Transcript
RefSeq:NM_001290077.1 TEK
RefSeq:NM_000459.4 TEK
RefSeq:NM_001290078.1 TEK
Other Identifiers
11727406_a_at
11748375_a_at
11750679_a_at
1595_at
1596_g_at
17084130
206702_PM_at
206702_at
217711_PM_at
217711_at
3165829
3165830
3165831
3165840
3165844
3165845
3165848
3165849
3165850
3165852
3165853
3165854
3165857
3165858
3165859
3165861
3165862
3165864
3165865
3165867
3165869
3165870
3165871
3165872
3165875
3165876
3165877
3165878
3165879
7010
8154692
A_14_P116356
A_14_P136657
A_23_P374695
GE57565
GO:0000166
GO:0001525
GO:0001666
GO:0001725
GO:0001934
GO:0001935
GO:0001938
GO:0001958
GO:0002040
GO:0002376
GO:0003013
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005515
GO:0005524
GO:0005576
GO:0005737
GO:0005815
GO:0005856
GO:0005884
GO:0005886
GO:0005902
GO:0005911
GO:0005925
GO:0006468
GO:0006629
GO:0006954
GO:0007155
GO:0007163
GO:0007165
GO:0007169
GO:0007267
GO:0007507
GO:0009925
GO:0009986
GO:0010033
GO:0010595
GO:0012501
GO:0014068
GO:0016020
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016525
GO:0016740
GO:0018108
GO:0019838
GO:0023052
GO:0030154
GO:0032878
GO:0033674
GO:0034330
GO:0034446
GO:0034451
GO:0035556
GO:0036211
GO:0038023
GO:0042802
GO:0043066
GO:0043114
GO:0043226
GO:0043235
GO:0043410
GO:0043434
GO:0043552
GO:0043627
GO:0045121
GO:0045766
GO:0046777
GO:0048014
GO:0048856
GO:0048870
GO:0050728
GO:0051591
GO:0051894
GO:0051897
GO:0060089
GO:0060216
GO:0060347
GO:0070161
GO:0070374
GO:0072012
GO:0072359
GO:0140096
GO:1902533
GO:2000351
GO:2000352
HMNXSV003039708
Hs.287335.0.A1_3p_at
Hs.287335.0.A1_3p_x_at
ILMN_2066151
L06139_at
TC09000121.hg
g4557868_3p_at
Participates
as a component of
ANGPT2:TEK [plasma membrane] (Homo sapiens)
ANGPT4:TEK [plasma membrane] (Homo sapiens)
ANGPT1:TEK [plasma membrane] (Homo sapiens)
as an input of
Interaction of Tie2 with Ang2 (Homo sapiens)
Interaction of Tie2 and Ang4 (Homo sapiens)
Interaction of Tie2 with Ang1 (Homo sapiens)
Other forms of this molecule
p-5Y,S1119-TEK [plasma membrane]
Inferred To
flor-1 [plasma membrane]
(Caenorhabditis elegans)
kin-30 [plasma membrane]
(Caenorhabditis elegans)
Homologues of TEK [plasma membrane]
(Caenorhabditis elegans)
Homologues of TEK [plasma membrane]
(Drosophila melanogaster)
TEK [plasma membrane]
(Bos taurus)
TEK [plasma membrane]
(Caenorhabditis elegans)
TEK [plasma membrane]
(Canis familiaris)
TEK [plasma membrane]
(Danio rerio)
TEK [plasma membrane]
(Drosophila melanogaster)
TEK [plasma membrane]
(Gallus gallus)
TEK [plasma membrane]
(Mus musculus)
TEK [plasma membrane]
(Rattus norvegicus)
TEK [plasma membrane]
(Sus scrofa)
TEK [plasma membrane]
(Xenopus tropicalis)
kin-9 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001277006.1
,
NP_000450.2
,
NP_001277007.1
ZINC - World Drugs
TIE2_HUMAN
Guide to Pharmacology - Targets
1842
OpenTargets
ENSG00000120156
ZINC - FDA approved
TIE2_HUMAN
ZINC - Substances
TIE2_HUMAN
ZINC - Biogenic
TIE2_HUMAN
ZINC target
Q02763
PRO
Q02763
PDB
7E72
,
5UTK
,
2GY7
,
5MYB
,
4K0V
,
3BEA
,
2OO8
,
2GY5
,
1FVR
,
4X3J
,
2P4I
,
2WQB
,
5MYA
,
6MWE
,
2OSC
,
3L8P
ZINC - Investigational
TIE2_HUMAN
ZINC - Metabolites
TIE2_HUMAN
GeneCards
Q02763
HPA
ENSG00000120156-TEK
Ensembl
ENSP00000369375
,
ENST00000380036
,
ENSG00000120156
,
ENSP00000383977
,
ENST00000406359
,
ENST00000519097
,
ENSP00000430686
Pharos - Targets
Q02763
Orphanet
15599
ZINC - Predictions - Purchasable
TIE2_HUMAN
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15123-1 ANGPT2
0.743
5
UniProt:O15123 ANGPT2
1
ANGPT2 [extracellular region]
(R-HSA-204801)
0.618
4
UniProt:Q15389 ANGPT1
1
ANGPT1 [extracellular region]
(R-HSA-204854)
0.609
2
UniProt:P62158 CALM
0.462
2
IntAct:EBI-11820565 HSPA1A
0.462
2
UniProt:P29353 SHC1
5
SHC1 [cytosol]
(R-HSA-74680)
p-Y427-SHC1 [cytosol]
(R-HSA-74684)
p-Y349,Y350-SHC1 [cytosol]
(R-HSA-180276)
p-Y-SHC1 [cytosol]
(R-HSA-162568)
p-Y349,Y350,Y427-SHC1 [cytosol]
(R-HSA-912321)
0.462
2
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