Reactome | BOC-1 [plasma membrane]

BOC-1 [plasma membrane]

Stable Identifier

R-HSA-197785

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Brother of CDO precursor, BOC_HUMAN, BOC isoform 1

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Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Myogenesis (Homo sapiens)
  - Activation of p38 alpha/beta MAPK (Homo sapiens)
    - p38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
    - pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
  - Bnip2 interacts with CDO complex (Homo sapiens)
    - CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
      - CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
    - Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
      - CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
  - CDO binds BOC (Homo sapiens)
    - BOC-1 [plasma membrane] (Homo sapiens)
    - CDO:BOC [plasma membrane] (Homo sapiens)
      - BOC-1 [plasma membrane] (Homo sapiens)
  - CDO binds promyogenic cadherins (Homo sapiens)
    - CDO:BOC [plasma membrane] (Homo sapiens)
      - BOC-1 [plasma membrane] (Homo sapiens)
    - CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
      - CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
  - Interaction of ABL1 with CDO complex (Homo sapiens)
    - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
    - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
  - Interaction of Bnip-2 with Cdc42 (Homo sapiens)
    - Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
      - CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
    - Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
  - Interaction of p38 MAPK with JLP (Homo sapiens)
    - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
    - p38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
  - JLP interacts with CDO complex (Homo sapiens)
    - Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
    - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
  - Neogenin:Netrin-3 binds CDO complex (Homo sapiens)
    - CDO:BOC [plasma membrane] (Homo sapiens)
      - BOC-1 [plasma membrane] (Homo sapiens)
    - CDO:BOC:Neogenin:Netrin-3 [plasma membrane] (Homo sapiens)
      - CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
  - Nuclear translocation of p38 MAPK (Homo sapiens)
    - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)
    - pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        CDO:BOC:Trans-cadherin homodimer:catenin [plasma membrane] (Homo sapiens)
        
        CDO:BOC [plasma membrane] (Homo sapiens)
        
        BOC-1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BWV1-1 BOC

Gene Names

BOC, UNQ604/PRO1190

Other Identifiers

11725693_a_at

16944010

224184_PM_s_at

224184_s_at

225990_PM_at

225990_at

2636338

2636339

2636340

2636342

2636362

2636363

2636364

2636382

2636384

2636388

2636389

2636391

2636392

2636395

2636396

2636398

2636399

2636400

2636401

2636405

2636406

2636407

2636411

2636413

2636415

2636416

2636417

2636418

2636419

2636460

52999_at

64423_s_at

8081686

91653

A_23_P257763

GE83630

GO:0005515

GO:0005886

GO:0007155

GO:0007399

GO:0007411

GO:0016020

GO:0030154

GO:0030424

GO:0044295

GO:0045663

GO:0048856

GO:0098609

HMNXSV003050373

HMNXSV003050750

Hs.153961.2.S2_3p_at

ILMN_1803956

PH_hs_0023101

TC03000577.hg

g13506660_3p_a_at

Participates

as an input of

CDO binds BOC (Homo sapiens)

as a component of

CDO:BOC [plasma membrane] (Homo sapiens)

Inferred To

boc [plasma membrane] (Xenopus tropicalis)

Boc [plasma membrane] (Mus musculus)

Boc [plasma membrane] (Rattus norvegicus)

wu:fa16d03 [plasma membrane] (Danio rerio)

BOC-1 [plasma membrane] (Drosophila melanogaster)

BOC-1 [plasma membrane] (Gallus gallus)

boi [plasma membrane] (Drosophila melanogaster)

BOC [plasma membrane] (Bos taurus)

BOC [plasma membrane] (Canis familiaris)

BOC [plasma membrane] (Sus scrofa)

Homologues of BOC-1 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_150279.1, XP_016862940.1, XP_005247949.1, NP_001288790.1, XP_011511607.1, XP_005247948.1

OpenTargets

ENSG00000144857

HPA

ENSG00000144857-BOC

GeneCards

Q9BWV1

Ensembl

ENST00000495514, ENSG00000144857, ENSP00000418663, ENSP00000273395, ENST00000273395, ENST00000355385, ENST00000682979, ENSP00000507783, ENSP00000347546

PRO

Q9BWV1

Pharos - Targets

Q9BWV1

PDB

3N1P, 3N1G, 3N1M

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43323 DHH	10	CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [extracellular region] (R-HSA-445155) CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [plasma membrane] (R-HSA-5362420) CHOL-N-palmitoyl-L-cysteine-DHH(23-198) [endoplasmic reticulum lumen] (R-HSA-5362442) ub-N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen] (R-HSA-5362411) ub-N4glycoAsn-DHH(199-396) [cytosol] (R-HSA-5362368) 2xHC-DHH(23-396) [endoplasmic reticulum lumen] (R-HSA-5358275) N4glycoAsn-DHH(199-396) [endoplasmic reticulum lumen] (R-HSA-5358287) CHOL-DHH(23-198) [endoplasmic reticulum lumen] (R-HSA-5358291) N4glycoAsn-2xHC-DHH(23-396) [endoplasmic reticulum lumen] (R-HSA-5362388) DHH(33-?) [extracellular region] (R-HSA-5362781)	0.558	2
UniProt:Q14623 IHH	10	CHOL-N-palmitoyl-L-cysteine-IHH(28-202) [extracellular region] (R-HSA-445149) CHOL-N-palmitoyl-L-cysteine-IHH(28-202) [plasma membrane] (R-HSA-5362425) CHOL-N-palmitoyl-L-cysteine-IHH(28-202) [endoplasmic reticulum lumen] (R-HSA-5362445) ub-N4glycoAsn-IHH(203-411) [endoplasmic reticulum lumen] (R-HSA-5362417) ub-N4glycoAsn-IHH(203-411) [cytosol] (R-HSA-5362393) 2xHC-IHH(28-411) [endoplasmic reticulum lumen] (R-HSA-5358277) N4glycoAsn-IHH(203-411) [endoplasmic reticulum lumen] (R-HSA-5358290) CHOL-IHH(28-202) [endoplasmic reticulum lumen] (R-HSA-5358293) N4glycoAsn-2xHC-IHH(28-411) [endoplasmic reticulum lumen] (R-HSA-5362390) IHH [extracellular region] (R-HSA-5362778)	0.558	2
UniProt:O35158	1	Cdon [plasma membrane] (R-RNO-197892)	0.524	2
UniProt:Q01721	1	Gas1 [plasma membrane] (R-MMU-449167)	0.524	2

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