Reactome | ROR1 [plasma membrane]

ROR1 [plasma membrane]

Stable Identifier

R-HSA-197814

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tyrosine-protein kinase transmembrane receptor ROR1 precursor, ROR1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q01973 ROR1

Gene Names

ROR1, NTRKR1

Chain

signal peptide:1-29, chain:30-937

Reference Genes

BioGPS Gene:4919 ROR1

COSMIC (genes):ROR1 ROR1

CTD Gene:4919 ROR1

dbSNP Gene:4919 ROR1

ENSEMBL:ENSG00000185483 ROR1

ENSEMBL_homo_sapiens_GENE:ENSG00000185483.13 ROR1

HGNC:10256 ROR1

KEGG Gene (Homo sapiens):4919 ROR1

Monarch:4919 ROR1

NCBI Gene:4919 ROR1

OMIM:602336 ROR1

UCSC:Q01973 ROR1

Reference Transcript

Other Identifiers

11738115_at

11752290_s_at

16665588

205805_PM_s_at

205805_s_at

211057_PM_at

211057_at

213_at

232060_PM_at

232060_at

2339873

2339874

2339875

2339876

2339932

2339942

2339945

2339966

2339967

2339968

2339969

2339976

2339983

2339984

2339985

2339986

2339987

2339988

2339996

2339998

4919

74338_at

7901969

85417_r_at

A_14_P114455

A_14_P122305

A_14_P136179

A_23_P12363

A_32_P4018

GE55619

GE62401

GO:0000166

GO:0001725

GO:0003824

GO:0004672

GO:0004714

GO:0005515

GO:0005524

GO:0005737

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0007169

GO:0007605

GO:0009986

GO:0010976

GO:0014002

GO:0015026

GO:0016020

GO:0016055

GO:0016301

GO:0016310

GO:0016740

GO:0017147

GO:0023052

GO:0030154

GO:0030424

GO:0036211

GO:0042813

GO:0042995

GO:0043123

GO:0043226

GO:0043235

GO:0043679

GO:0048839

GO:0048856

GO:0050877

GO:0051092

GO:0051897

GO:0060089

GO:0140096

HMNXSV003003405

Hs.128753.0.S1_3p_at

ILMN_1655904

ILMN_1899404

M97675_at

PH_hs_0007467

PH_hs_0014128

TC01000723.hg

TC01004449.hg

g13623530_3p_at

g4826867_3p_a_at

Participates

as a candidate of

FZD2/FZD5/ROR2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

ROR1 [clathrin-coated endocytic vesicle membrane]

Inferred To

Ror1 [plasma membrane] (Rattus norvegicus)

ROR1 [plasma membrane] (Bos taurus)

ROR1 [plasma membrane] (Caenorhabditis elegans)

ROR1 [plasma membrane] (Canis familiaris)

ROR1 [plasma membrane] (Drosophila melanogaster)

ROR1 [plasma membrane] (Gallus gallus)

ROR1 [plasma membrane] (Mus musculus)

ROR1 [plasma membrane] (Sus scrofa)

ROR1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001077061.1, NP_005003.2

Guide to Pharmacology - Targets

1845

OpenTargets

ENSG00000185483

GeneCards

Q01973

HPA

ENSG00000185483-ROR1

Ensembl

ENSG00000185483, ENSP00000360121, ENSP00000360120, ENST00000371079, ENST00000371080

PRO

Q01973

Pharos - Targets

Q01973

Orphanet

25518

HMDB Protein

HMDBP09450

PDB

7TNG, 6TU9, 6BA5, 5Z55, 6BAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.682	9
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.576	8
UniProt:P05480 Src	13	SRC-2 [cytosol] (R-MMU-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-MMU-1810408) SRC-1 [plasma membrane] (R-MMU-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-MMU-377598) phospho-p-Y419-SRC [cytosol] (R-MMU-377592) Src [cytosol] (R-MMU-418782) phospho-p-Y419-SRC-1 [plasma membrane] (R-MMU-112331) MyrG-SRC [plasma membrane] (R-MMU-8876922) phospho-p-Y419-SRC [cytosol] (R-MMU-8964276) SRC [cytosol] (R-MMU-9628701) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) Activated Src [nucleoplasm] (R-MMU-8937700) p-Y416-Src [cytosol] (R-MMU-8964306)	0.544	2
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.483	2

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