Reactome | SALM3 [plasma membrane]

SALM3 [plasma membrane]

Stable Identifier

R-HSA-197883

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

LRFN4, Leucine-rich repeat and fibronectin type-III domain-containing protein 4 precursor, LRFN4_HUMAN

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External Reference Information

External Reference

UniProt:Q6PJG9 LRFN4

Gene Names

LRFN4, SALM3

Chain

signal peptide:1-16, chain:17-635

Reference Genes

BioGPS Gene:78999 LRFN4

COSMIC (genes):LRFN4 LRFN4

CTD Gene:78999 LRFN4

dbSNP Gene:78999 LRFN4

ENSEMBL:ENSG00000173621 LRFN4

HGNC:28456 LRFN4

KEGG:hsa:78999 LRFN4

Monarch:78999 LRFN4

NCBI Gene:78999 LRFN4

OMIM:612810 LRFN4

UCSC:Q6PJG9 LRFN4

Reference Transcript

Other Identifiers

11722296_at

11722297_s_at

16727616

219491_3p_at

219491_PM_at

219491_at

238092_PM_at

238092_at

3336577

3336578

3336579

3336580

3336581

3336582

3336583

3336586

3336587

3336588

3336589

3336590

3336591

3336592

3336593

54986_at

78999

7941743

80420_at

A_14_P138952

A_23_P63980

A_33_P3280094

GE82766

GO:0005515

GO:0005886

GO:0007155

GO:0009986

GO:0016020

GO:0098839

GO:0098978

GO:0098982

GO:0099151

GO:0099560

GO:1905606

HMNXSV003050078

Hs.148438.0.A1_3p_at

ILMN_1809417

PH_hs_0022645

PH_hs_0030807

TC11000675.hg

TC11002732.hg

g13128987_3p_at

g13128987_3p_s_at

Participates

as a candidate of

SALM2,3(SALM1,4) [plasma membrane] (Homo sapiens)

as a component of

SALM3:LAR-RPTPs [plasma membrane] (Homo sapiens)

as an input of

SALM3 binds LAR-RPTP (Homo sapiens)

as a member of

SALM1,2,3 [plasma membrane] (Homo sapiens)

Inferred To

Lrfn4 [plasma membrane] (Mus musculus)

Lrfn4 [plasma membrane] (Rattus norvegicus)

LRFN4 [plasma membrane] (Bos taurus)

LRFN4 [plasma membrane] (Canis familiaris)

kek5 [plasma membrane] (Drosophila melanogaster)

lrfn4 [plasma membrane] (Xenopus tropicalis)

unc-89 [plasma membrane] (Caenorhabditis elegans)

Cross References

OpenTargets

ENSG00000173621

ENSEMBL

ENSG00000173621, ENSP00000312535, ENST00000309602

GeneCards

LRFN4

HPA

ENSG00000173621-LRFN4

PRO

Q6PJG9

Pharos - Targets

Q6PJG9

GlyGen

Q6PJG9

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16333 NCK1	2	NCK1 [plasma membrane] (R-HSA-202992) NCK1 [cytosol] (R-HSA-197954)	0.69	11
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.69	13
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.643	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q6UY14-3 ADAMTSL4			0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q8IUG1 KRTAP1-3	1	KRTAP1-3 [cytosol] (R-HSA-6809866)	0.556	3
UniProt:Q3LI66 KRTAP6-2	1	KRTAP6-2 [cytosol] (R-HSA-6810261)	0.556	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:Q70CQ3 USP30	2	USP30 [mitochondrial outer membrane] (R-HSA-5696931) USP30 [peroxisomal membrane] (R-HSA-9674135)	0.527	2
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.527	2
UniProt:Q9H3P7 ACBD3	1	ACBD3 [Golgi membrane] (R-HSA-8874981)	0.527	2
UniProt:A6NDU8 RIMC1			0.527	2
UniProt:O75146 HIP1R	3	HIP1R [cytosol] (R-HSA-8868155) HIP1R [Golgi membrane] (R-HSA-434348) HIP1R [cytoplasmic vesicle membrane] (R-HSA-434201)	0.527	2
UniProt:P09382 LGALS1	2	LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711) p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003)	0.527	3
UniProt:Q9H649 NSUN3			0.527	2
UniProt:Q9GZU3 TM39B			0.527	2
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.527	2
UniProt:Q9UHP3 USP25	1	USP25 [cytosol] (R-HSA-5696900)	0.527	2
UniProt:Q15654 TRIP6			0.527	2
UniProt:Q9Y6Q1 CAPN6	1	CAPN6 [cytosol] (R-HSA-8848635)	0.527	2
UniProt:Q8TCG1 CIP2A			0.527	2
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.527	2
UniProt:O75970 MPDZ			0.527	2
UniProt:O94991 SLITRK5	1	SLITRK5 [plasma membrane] (R-HSA-6797834)	0.527	2
UniProt:P0C7P0 CISD3			0.527	2
UniProt:P05496 ATP5MC1	5	ATP5G1(1-136) [mitochondrial inner membrane] (R-HSA-1299432) ATP5G1(1-136) [mitochondrial intermembrane space] (R-HSA-1267972) ATP5G1(1-136) [cytosol] (R-HSA-1267993) ATP5G1(1-61) [mitochondrial matrix] (R-HSA-8986143) ATP5MC1 [mitochondrial inner membrane] (R-HSA-164535)	0.527	2
UniProt:Q8NEG5 ZSWM2			0.527	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.462	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.462	3
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.462	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.462	3

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