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Go!
ICOSLG [plasma membrane]
Stable Identifier
R-HSA-197910
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ICOSL, ICOS ligand precursor, ICOL_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
ICOS binds ICOSL/B7-H2 (Homo sapiens)
ICOS:ICOSL [plasma membrane] (Homo sapiens)
ICOSLG [plasma membrane] (Homo sapiens)
ICOSLG [plasma membrane] (Homo sapiens)
PI3K binds ICOS (Homo sapiens)
ICOS:ICOSL [plasma membrane] (Homo sapiens)
ICOSLG [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75144 ICOSLG
Gene Names
ICOSLG, B7H2, B7RP1, ICOSL, KIAA0653
Chain
signal peptide:1-18, chain:19-302
Reference Genes
BioGPS Gene:23308 ICOSLG
COSMIC (genes):ICOSLG ICOSLG
CTD Gene:23308 ICOSLG
dbSNP Gene:23308 ICOSLG
ENSEMBL:ENSG00000160223 ICOSLG
ENSEMBL_homo_sapiens_GENE:ENSG00000160223.18 ICOSLG
HGNC:17087 ICOSLG
KEGG Gene (Homo sapiens):23308 ICOSLG
Monarch:23308 ICOSLG
NCBI Gene:23308 ICOSLG
OMIM:605717 ICOSLG
UCSC:O75144 ICOSLG
Reference Transcript
RefSeq:NM_001283051.1 ICOSLG
RefSeq:NM_001283050.1 ICOSLG
RefSeq:XM_006723900.2 ICOSLG
RefSeq:NM_015259.5 ICOSLG
Other Identifiers
102723996
11739295_a_at
11739296_a_at
16926302
211197_PM_s_at
211197_s_at
211198_PM_s_at
211198_s_at
211199_PM_s_at
211199_s_at
213450_PM_s_at
213450_s_at
228976_PM_at
228976_at
23308
31803_at
3934404
3934406
3934408
3934409
3934410
3934411
3934412
3934413
3934414
3934415
3934416
3934417
3934418
3934422
3934424
3934425
3934426
3934427
3934428
3934430
57680_at
8070720
A_23_P166280
A_23_P317667
A_23_P6272
GE490101
GE528212
GE53364
GO:0001817
GO:0002250
GO:0002376
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006952
GO:0006972
GO:0007155
GO:0007165
GO:0009897
GO:0016020
GO:0023052
GO:0042104
GO:0042110
GO:0042113
GO:0042802
GO:0043226
GO:0043231
GO:0050852
GO:0070062
HMNXSV003002205
HMNXSV003003730
HMNXSV003011829
Hs.14155.0.S3_3p_a_at
Hs.14155.2.S1_3p_a_at
Hs.65578.0.A1_3p_at
ILMN_1675671
ILMN_1878718
PH_hs_0001352
PH_hs_0004023
TC21000516.hg
g6983943_3p_a_at
g9858866_3p_a_at
Participates
as an input of
ICOS binds ICOSL/B7-H2 (Homo sapiens)
as a component of
ICOS:ICOSL [plasma membrane] (Homo sapiens)
Inferred To
LICOS [plasma membrane]
(Gallus gallus)
ICOSLG [plasma membrane]
(Bos taurus)
ICOSLG [plasma membrane]
(Canis familiaris)
ICOSLG [plasma membrane]
(Sus scrofa)
Icoslg [plasma membrane]
(Mus musculus)
Icoslg [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_006723963.1
,
NP_056074.1
,
NP_001269979.1
,
NP_001269980.1
OpenTargets
ENSG00000160223
GeneCards
O75144
HPA
ENSG00000160223-ICOSLG
Ensembl
ENST00000407780
,
ENSG00000160223
,
ENSP00000384432
,
ENSP00000383228
,
ENSP00000339477
,
ENST00000400377
,
ENST00000344330
PRO
O75144
Pharos - Targets
O75144
Orphanet
29638
PDB
6X4T
,
6X4G
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6W8 ICOS
1
ICOS [plasma membrane]
(R-HSA-9845023)
0.733
8
UniProt:O75144 ICOSLG
1
ICOSLG [plasma membrane]
(R-HSA-197910)
0.672
7
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