Reactome | PTPRC [plasma membrane]

PTPRC [plasma membrane]

Stable Identifier

R-HSA-197931

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Leukocyte common antigen precursor, CD45_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P08575 PTPRC

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External Reference Information

External Reference

UniProt:P08575 PTPRC

Gene Names

PTPRC, CD45

Chain

signal peptide:1-25, chain:26-1306

Reference Genes

BioGPS Gene:5788 PTPRC

COSMIC (genes):PTPRC PTPRC

CTD Gene:5788 PTPRC

dbSNP Gene:5788 PTPRC

ENSEMBL:ENSG00000081237 PTPRC

HGNC:9666 PTPRC

KEGG:hsa:5788 PTPRC

Monarch:5788 PTPRC

NCBI Gene:5788 PTPRC

OMIM:151460 PTPRC

UCSC:P08575 PTPRC

Reference Transcript

Other Identifiers

11733344_at

11739334_a_at

11743559_a_at

11743560_a_at

11743561_a_at

11752095_a_at

1552480_3p_s_at

1552480_PM_s_at

1552480_s_at

1569830_PM_at

1569830_at

16675578

207238_PM_s_at

207238_s_at

212587_PM_s_at

212587_s_at

212588_PM_at

212588_at

2373852

2373853

2373854

2373855

2373856

2373875

2373876

2373877

2373878

2373879

2373880

2373882

2373884

2373885

2373886

2373887

2373888

2373889

2373890

2373891

2373892

2373893

2373894

2373895

2373898

2373900

2373901

2373907

2373908

2373910

2373911

2373912

2373913

2373914

2373915

2373916

2373919

2373921

2373922

2373923

2373924

2373925

2373928

2373929

2373930

2373931

2373932

2373933

2373934

2373936

2373937

2373938

2373939

2373940

2373941

2373942

2373943

2373956

239467_PM_at

239467_at

40518_at

40520_g_at

56668_at

5788

58587_at

77345_at

7908553

89248_r_at

A_14_P101884

A_14_P136733

A_23_P12392

A_23_P125451

A_33_P3309526

A_33_P3364808

A_33_P3364811

A_33_P3364821

GE60225

GE731632

GE870138

GO:0000165

GO:0001779

GO:0001915

GO:0001916

GO:0001960

GO:0002244

GO:0002376

GO:0002639

GO:0002711

GO:0002923

GO:0002925

GO:0003824

GO:0004721

GO:0004725

GO:0005001

GO:0005102

GO:0005515

GO:0005886

GO:0005925

GO:0006469

GO:0006470

GO:0006933

GO:0007155

GO:0007159

GO:0007166

GO:0008092

GO:0008201

GO:0009897

GO:0009898

GO:0009986

GO:0010332

GO:0010468

GO:0016020

GO:0016311

GO:0016787

GO:0019901

GO:0030154

GO:0030183

GO:0030217

GO:0030506

GO:0030507

GO:0030667

GO:0030890

GO:0031953

GO:0032059

GO:0032677

GO:0032703

GO:0032743

GO:0032760

GO:0034113

GO:0042098

GO:0042100

GO:0042102

GO:0042110

GO:0042492

GO:0043226

GO:0043395

GO:0043410

GO:0044770

GO:0044855

GO:0045059

GO:0045060

GO:0045121

GO:0045202

GO:0045582

GO:0045588

GO:0045860

GO:0046425

GO:0046633

GO:0046641

GO:0048304

GO:0048539

GO:0048856

GO:0048864

GO:0050731

GO:0050732

GO:0050764

GO:0050766

GO:0050850

GO:0050852

GO:0050853

GO:0050856

GO:0050857

GO:0051209

GO:0051607

GO:0051726

GO:0055085

GO:0060089

GO:0060369

GO:0061024

GO:0061097

GO:0070062

GO:0070373

GO:0070374

GO:0071944

GO:0097191

GO:0098542

GO:0098857

GO:0140096

GO:1903979

GO:1904044

GO:1904155

GO:2000473

GO:2000648

GO:2001236

GO:2001238

HMNXSV003006596

HMNXSV003040906

HMNXSV003045353

HMNXSV003046238

Hs.170121.1.A1_3p_a_at

Hs.170121.1.A3_3p_at

Hs.89257.0.A1_3p_at

Hs2.170121.1.A1_3p_at

Hs2.170121.1.A1_3p_s_at

Hs2.382632.1.S1_3p_at

ILMN_1653652

ILMN_1730842

ILMN_1804279

ILMN_2340217

PH_hs_0025956

TC01001640.hg

Y00062_at

g4506306_3p_a_at

Participates

as a member of

as a component of

SEMA4D:PTPRC [plasma membrane] (Homo sapiens)

as an input of

SEMA4D interacts with CD45 (Homo sapiens)

Other forms of this molecule

PTPRC [secretory granule membrane]

Inferred To

PTP3 [plasma membrane] (Saccharomyces cerevisiae)

Ptp52F [plasma membrane] (Drosophila melanogaster)

Homologues of PTPRC [plasma membrane] (Dictyostelium discoideum)

Homologues of PTPRC [plasma membrane] (Drosophila melanogaster)

Homologues of PTPRC [plasma membrane] (Saccharomyces cerevisiae)

Homologues of PTPRC [plasma membrane] (Schizosaccharomyces pombe)

pyp2 [plasma membrane] (Schizosaccharomyces pombe)

PTP1 [plasma membrane] (Saccharomyces cerevisiae)

ptpA1-2 [plasma membrane] (Dictyostelium discoideum)

pyp1 [plasma membrane] (Schizosaccharomyces pombe)

ptpB [plasma membrane] (Dictyostelium discoideum)

pyp3 [plasma membrane] (Schizosaccharomyces pombe)

ptpC [plasma membrane] (Dictyostelium discoideum)

PTP2 [plasma membrane] (Saccharomyces cerevisiae)

PTPRC [plasma membrane] (Bos taurus)

PTPRC [plasma membrane] (Caenorhabditis elegans)

PTPRC [plasma membrane] (Canis familiaris)

PTPRC [plasma membrane] (Drosophila melanogaster)

PTPRC [plasma membrane] (Gallus gallus)

PTPRC [plasma membrane] (Mus musculus)

PTPRC [plasma membrane] (Rattus norvegicus)

PTPRC [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_563578.2, NP_002829.3, XP_006711536.1, XP_006711535.1, XP_006711537.1

Guide to Pharmacology - Targets

1852

OpenTargets

ENSG00000081237

ENSEMBL

ENSP00000306782, ENST00000697631, ENST00000573477, ENSP00000461074, ENSP00000458322, ENST00000442510, ENSP00000513363, ENST00000573679, ENST00000348564, ENSP00000411355

ZINC - Substances

PTPRC_HUMAN

ZINC - Biogenic

PTPRC_HUMAN

ZINC target

P08575

PRO

P08575

GlyGen

P08575

PDB

5FMV, 5FN7, 1YGR, 5FN6, 1YGU

HPA

ENSG00000081237-PTPRC

Pharos - Targets

P08575

Orphanet

PTPRC

ZINC - Predictions - Purchasable

PTPRC_HUMAN

HMDB Protein

HMDBP02584

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.851	7
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.623	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.609	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.592	2
UniProt:P09382 LGALS1	2	LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711) p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003)	0.558	2
UniProt:P08575 PTPRC	2	PTPRC [plasma membrane] (R-HSA-197931) PTPRC [secretory granule membrane] (R-HSA-6806150)	0.509	2
UniProt:P20701 ITGAL	2	ITGAL [plasma membrane] (R-HSA-198013) ITGAL [specific granule membrane] (R-HSA-6799536)	0.508	2

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