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LYN [plasma membrane]
Stable Identifier
R-HSA-197943
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tyrosine-protein kinase LYN, LYN_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P01023 A2M
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
Autophosphorylation of LYN kinase (Homo sapiens)
LYN [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07948 LYN
Gene Names
LYN, JTK8
Chain
initiator methionine:, chain:2-512
Reference Genes
BioGPS Gene:4067 LYN
COSMIC (genes):LYN LYN
CTD Gene:4067 LYN
dbSNP Gene:4067 LYN
ENSEMBL:ENSG00000254087 LYN
ENSEMBL_homo_sapiens_GENE:ENSG00000254087.8 LYN
HGNC:6735 LYN
KEGG Gene (Homo sapiens):4067 LYN
Monarch:4067 LYN
NCBI Gene:4067 LYN
OMIM:165120 LYN
UCSC:P07948 LYN
Reference Transcript
RefSeq:NM_001111097.2 LYN
RefSeq:NM_002350.3 LYN
RefSeq:XM_017013416.1 LYN
Other Identifiers
11718084_a_at
11718085_s_at
11732514_s_at
1402_at
17069063
2024_s_at
202625_PM_at
202625_at
202626_PM_s_at
202626_s_at
210754_PM_s_at
210754_s_at
3098978
3098979
3098997
3098998
3098999
3099000
3099001
3099002
3099005
3099006
3099007
3099010
3099011
3099024
3099026
3099028
3099029
3099030
3099050
32616_at
4067
54933_at
77231_at
8146500
A_14_P123503
A_23_P147431
GE57840
GO:0000077
GO:0000166
GO:0001782
GO:0001817
GO:0001932
GO:0001933
GO:0001934
GO:0002223
GO:0002244
GO:0002250
GO:0002376
GO:0002431
GO:0002513
GO:0002553
GO:0002576
GO:0002762
GO:0002768
GO:0002774
GO:0002862
GO:0002902
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005161
GO:0005178
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005739
GO:0005764
GO:0005765
GO:0005773
GO:0005794
GO:0005829
GO:0005886
GO:0005912
GO:0006468
GO:0006954
GO:0006974
GO:0006991
GO:0007155
GO:0007165
GO:0007169
GO:0008092
GO:0008284
GO:0008285
GO:0008289
GO:0009410
GO:0009636
GO:0009725
GO:0009743
GO:0009898
GO:0009986
GO:0010976
GO:0012501
GO:0014003
GO:0014070
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0017124
GO:0018108
GO:0019899
GO:0023052
GO:0030061
GO:0030097
GO:0030154
GO:0030218
GO:0030222
GO:0030335
GO:0030666
GO:0030889
GO:0031175
GO:0031234
GO:0031295
GO:0031410
GO:0031625
GO:0031663
GO:0031668
GO:0031966
GO:0032868
GO:0032991
GO:0033003
GO:0033628
GO:0034136
GO:0034142
GO:0034144
GO:0034605
GO:0034666
GO:0035556
GO:0036211
GO:0038043
GO:0038095
GO:0038096
GO:0038159
GO:0042060
GO:0042327
GO:0042531
GO:0043015
GO:0043200
GO:0043208
GO:0043226
GO:0043231
GO:0043304
GO:0043407
GO:0043410
GO:0043434
GO:0044325
GO:0044877
GO:0045087
GO:0045121
GO:0045646
GO:0046777
GO:0046875
GO:0048013
GO:0048471
GO:0048678
GO:0048856
GO:0048870
GO:0050727
GO:0050777
GO:0050853
GO:0050855
GO:0050900
GO:0051219
GO:0051279
GO:0055065
GO:0055085
GO:0060252
GO:0060369
GO:0060397
GO:0070062
GO:0070372
GO:0070373
GO:0070447
GO:0070667
GO:0070668
GO:0071300
GO:0090025
GO:0090330
GO:0097028
GO:0097110
GO:0098542
GO:0098978
GO:0099091
GO:0140031
GO:0140096
GO:0141038
GO:1902532
GO:1902961
GO:2000670
HMNXSV003009154
Hs.80887.0.A2_3p_at
ILMN_1781155
M16038_at
PH_hs_0004647
TC08000383.hg
g187270_3p_a_at
g4505054_3p_a_at
Participates
as an input of
Autophosphorylation of LYN kinase (Homo sapiens)
Other forms of this molecule
MyrG2-PalmC3-LYN [lysosomal membrane]
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
p-Y397-LYN [cytosol]
p-Y397-LYN [plasma membrane]
MyrG2-PalmC3-LYN [plasma membrane]
LYN [cytosol]
Inferred To
LYN [plasma membrane]
(Bos taurus)
LYN [plasma membrane]
(Caenorhabditis elegans)
LYN [plasma membrane]
(Canis familiaris)
LYN [plasma membrane]
(Drosophila melanogaster)
LYN [plasma membrane]
(Gallus gallus)
LYN [plasma membrane]
(Mus musculus)
LYN [plasma membrane]
(Rattus norvegicus)
LYN [plasma membrane]
(Sus scrofa)
LYN [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001104567.1
,
XP_016868905.1
,
NP_002341.1
ZINC - World Drugs
LYN_HUMAN
Guide to Pharmacology - Targets
2060
OpenTargets
ENSG00000254087
ZINC - FDA approved
LYN_HUMAN
ZINC - Substances
LYN_HUMAN
ZINC target
P07948
ZINC - Biogenic
LYN_HUMAN
PRO
P07948
PDB
1W1F
,
6NMW
,
3A4O
,
8WFF
,
5XY1
,
1WA7
ZINC - Investigational
LYN_HUMAN
IntEnz
2.7.10.2
GeneCards
P07948
HPA
ENSG00000254087-LYN
Ensembl
ENSP00000428424
,
ENSP00000428924
,
ENST00000520220
,
ENST00000519728
,
ENSG00000254087
Pharos - Targets
P07948
ZINC - Predictions - Purchasable
LYN_HUMAN
HMDB Protein
HMDBP13811
Interactors (44)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.82
7
UniProt:P27958 POLG
1
POLG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HCV-8854138)
0.704
4
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.669
4
UniProt:Q9WMX2 POLG
0.667
3
UniProt:Q9NWQ8 PAG1
2
PAG1 [plasma membrane]
(R-HSA-180500)
p-Y317-PAG1 [plasma membrane]
(R-HSA-180494)
0.641
16
UniProt:Q9HCN6 GP6
1
GP6 [plasma membrane]
(R-HSA-114574)
0.641
5
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.609
2
UniProt:Q13444 ADAM15
1
ADAM15 [plasma membrane]
(R-HSA-708329)
0.609
2
UniProt:Q8NDB2 BANK1
0.591
3
UniProt:O92972 POLG
0.589
2
UniProt:Q05397 PTK2
11
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.573
2
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.564
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.564
2
UniProt:P22575 TIP
0.558
3
UniProt:Q8R5G7
1
Arap3 [cytosol]
(R-MMU-195185)
0.558
2
UniProt:O43184 ADAM12
1
ADAM12 [plasma membrane]
(R-HSA-179792)
0.558
2
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:P50570-2 DNM2
0.556
3
UniProt:P51608 MECP2
0.556
3
UniProt:Q96L34 MARK4
1
MARK4 [cytosol]
(R-HSA-5626653)
0.556
3
UniProt:Q96GW7 BCAN
20
D2,4,4(S)3-BCAN(361-911) [extracellular region]
(R-HSA-3791190)
CSE-BCAN(361-911) [extracellular region]
(R-HSA-3791188)
C6S-BCAN(361-911) [extracellular region]
(R-HSA-3791186)
C4S-BCAN(361-911) [extracellular region]
(R-HSA-3791182)
D2,4(S)2-BCAN(361-911) [extracellular region]
(R-HSA-3791181)
D4S-BCAN(361-911) [extracellular region]
(R-HSA-3791193)
D4S-BCAN(23-360) [extracellular region]
(R-HSA-3791191)
D2,4(S)2-BCAN(23-360) [extracellular region]
(R-HSA-3791189)
C6S-BCAN(23-360) [extracellular region]
(R-HSA-3791184)
D2,4,4(S)3-BCAN(23-360) [extracellular region]
(R-HSA-3791180)
C4S-BCAN(23-360) [extracellular region]
(R-HSA-3791179)
CSE-BCAN(23-360) [extracellular region]
(R-HSA-3791192)
D2,4(S)2-BCAN(23-395) [extracellular region]
(R-HSA-3791174)
D2,4,4(S)3-BCAN(23-395) [extracellular region]
(R-HSA-3791127)
C6S-BCAN(23-395) [extracellular region]
(R-HSA-3791162)
C4S-BCAN(23-395) [extracellular region]
(R-HSA-3791130)
D4S-BCAN(23-395) [extracellular region]
(R-HSA-3791147)
CSE-BCAN(23-395) [extracellular region]
(R-HSA-3791131)
C4S-BCAN(396-911) [extracellular region]
(R-HSA-3791157)
D2,4,4(S)3-BCAN(396-911) [extracellular region]
(R-HSA-3791170)
0.556
3
UniProt:P01023 A2M
2
A2M [extracellular region]
(R-HSA-49291)
A2M [platelet alpha granule lumen]
(R-HSA-139834)
0.556
3
UniProt:P07602 PSAP
11
PSAP(60-142) [extracellular region]
(R-HSA-351338)
PSAP(17-524) [plasma membrane]
(R-HSA-6806262)
PSAP(17-524) [azurophil granule membrane]
(R-HSA-6799212)
PSAP(311-391) [lysosomal lumen]
(R-HSA-9851355)
PSAP(405-486) [lysosomal lumen]
(R-HSA-9840328)
PSAP(311-391) [lysosomal membrane]
(R-HSA-1605602)
PSAP(60-142) [lysosomal lumen]
(R-HSA-351333)
PSAP [lysosomal lumen]
(R-HSA-9840325)
PSAP(195-273) [lysosomal lumen]
(R-HSA-9840336)
PSAP(?-?) [extracellular region]
(R-HSA-5336190)
PSAP(326-340) [extracellular region]
(R-HSA-5336179)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P27986-2 PIK3R1
0.556
3
UniProt:Q9BS26 ERP44
2
ERP44 [extracellular region]
(R-HSA-6806302)
ERP44 [specific granule lumen]
(R-HSA-6799567)
0.556
3
UniProt:P46527 CDKN1B
8
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
CDKN1B [cytosol]
(R-HSA-198622)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
0.544
2
UniProt:O95684 CEP43
3
FGFR1OP(2-163)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1604533)
FGFR1OP(2-163)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838994)
FGFR1OP [cytosol]
(R-HSA-380309)
0.527
2
UniProt:Q9NQW6 ANLN
1
ANLN [cytosol]
(R-HSA-9690261)
0.527
2
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.527
2
UniProt:P09769 FGR
3
FGR [extracellular region]
(R-HSA-6806524)
FGR [secretory granule lumen]
(R-HSA-6804974)
FGR [cytosol]
(R-HSA-432116)
0.527
3
UniProt:P08631 HCK
2
p-HCK [cytosol]
(R-HSA-9676060)
HCK [cytosol]
(R-HSA-167708)
0.527
3
UniProt:Q9HCN6-1 GP6
0.524
2
UniProt:Q15642 TRIP10
1
TRIP10 [cytosol]
(R-HSA-195120)
0.508
2
UniProt:P16671 CD36
5
CD36 [platelet alpha granule membrane]
(R-HSA-114687)
4xPalmC-CD36 [specific granule membrane]
(R-HSA-6806151)
CD36 [phagocytic vesicle]
(R-HSA-1236835)
4xPalmC-CD36 [endocytic vesicle membrane]
(R-HSA-2239449)
4xPalmC-CD36 [plasma membrane]
(R-HSA-51645)
0.499
3
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.499
4
UniProt:Q6UWF3 SCIMP
0.499
3
UniProt:Q08857 Cd36
6
Cd36 [platelet alpha granule membrane]
(R-MMU-114687)
Cd36 [specific granule membrane]
(R-MMU-6806151)
Cd36 [phagocytic vesicle]
(R-MMU-1236835)
Cd36 [endocytic vesicle membrane]
(R-MMU-2239449)
Cd36 [plasma membrane]
(R-MMU-51645)
Cd36 [plasma membrane]
(R-MMU-2187219)
0.499
2
UniProt:P11049 CD37
0.499
5
UniProt:P14317 HCLS1
0.499
2
UniProt:P20273 CD22
3
NAc-CD22 [plasma membrane]
(R-HSA-5690736)
CD22 [plasma membrane]
(R-HSA-197703)
p-Y762,807,822-CD22 [plasma membrane]
(R-HSA-5690726)
0.499
2
UniProt:P25063 CD24
1
CD24(29-534) [plasma membrane]
(R-HSA-430062)
0.499
6
UniProt:P61980
2
Hnrnpk [nucleoplasm]
(R-RNO-4570532)
Hnrnpk [nucleoplasm]
(R-RNO-71945)
0.469
2
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