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NCK1 [cytosol]
Stable Identifier
R-HSA-197954
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cytoplasmic protein NCK1, NCK1_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q13094 LCP2
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
DCC mediated attractive signaling (Homo sapiens)
DCC interacting NCK-1 (Homo sapiens)
NCK1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
NCK1 [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
p-SLP-76 binds NCK (Homo sapiens)
NCK1 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
NCK1 binds PKR (Homo sapiens)
NCK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16333 NCK1
Gene Names
NCK1, NCK
Chain
initiator methionine:, chain:2-377
Reference Genes
BioGPS Gene:4690 NCK1
COSMIC (genes):NCK1 NCK1
CTD Gene:4690 NCK1
dbSNP Gene:4690 NCK1
ENSEMBL:ENSG00000158092 NCK1
ENSEMBL_homo_sapiens_GENE:ENSG00000158092.7 NCK1
HGNC:7664 NCK1
KEGG Gene (Homo sapiens):4690 NCK1
Monarch:4690 NCK1
NCBI Gene:4690 NCK1
OMIM:600508 NCK1
UCSC:P16333 NCK1
Reference Transcript
RefSeq:NM_001291999.1 NCK1
RefSeq:NM_006153.5 NCK1
RefSeq:NM_001190796.2 NCK1
Other Identifiers
11729219_at
16946063
204725_PM_s_at
204725_s_at
211063_PM_s_at
211063_s_at
236922_PM_at
236922_at
244487_PM_at
244487_at
2644156
2644157
2644165
2644168
2644170
2644171
2644172
2644175
2644176
2644177
2644178
2644179
2644195
2644197
2644199
41795_at
4690
77058_at
8082911
81605_at
989_at
A_14_P126342
A_23_P255785
GE59747
GE598177
GO:0000122
GO:0000164
GO:0002181
GO:0002376
GO:0004860
GO:0005102
GO:0005515
GO:0005634
GO:0005737
GO:0005783
GO:0005829
GO:0005840
GO:0005886
GO:0005911
GO:0006351
GO:0006355
GO:0006417
GO:0006930
GO:0007010
GO:0007015
GO:0007155
GO:0007165
GO:0007172
GO:0008093
GO:0010976
GO:0012501
GO:0012506
GO:0016477
GO:0019904
GO:0023052
GO:0030032
GO:0030154
GO:0030159
GO:0030334
GO:0030674
GO:0030838
GO:0030971
GO:0033137
GO:0034976
GO:0035591
GO:0036211
GO:0036493
GO:0042102
GO:0042110
GO:0043226
GO:0045296
GO:0045944
GO:0046627
GO:0046875
GO:0048013
GO:0048856
GO:0048870
GO:0051707
GO:0060090
GO:0065003
GO:0071074
GO:0098542
GO:0098772
GO:0140374
GO:0140693
GO:1902237
GO:1902310
GO:1903676
GO:1903679
GO:1903898
GO:1903912
HMNXSV003048711
Hs.121645.0.A1_3p_at
Hs.126889.0.A1_3p_at
Hs.126889.0.A1_3p_x_at
ILMN_1698001
ILMN_1821397
PH_hs_0007246
PH_hs_0027654
TC03003323.hg
X17576_at
g13623576_3p_s_at
g5453753_3p_s_at
Participates
as a candidate of
RHOV effectors [cytosol] (Homo sapiens)
RHOU effectors [cytosol] (Homo sapiens)
as an input of
NCK1 binds PKR (Homo sapiens)
p-SLP-76 binds NCK (Homo sapiens)
DCC interacting NCK-1 (Homo sapiens)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Homo sapiens)
as a component of
EIF2AK2:NCK1 [cytosol] (Homo sapiens)
p-SLP-76:NCK1 [cytosol] (Homo sapiens)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:p-Y223,Y551-BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Homo sapiens)
as a member of
SH3 domain proteins [cytosol] (Homo sapiens)
NCK1,NCK2 [cytosol] (Homo sapiens)
Other forms of this molecule
NCK1 [plasma membrane]
Inferred To
Nck1 [cytosol]
(Mus musculus)
Nck1 [cytosol]
(Rattus norvegicus)
NCK1 [cytosol]
(Bos taurus)
NCK1 [cytosol]
(Canis familiaris)
NCK1 [cytosol]
(Drosophila melanogaster)
NCK1 [cytosol]
(Sus scrofa)
nck1b [cytosol]
(Danio rerio)
Ghost homologue of NCK1 [cytosol]
(Gallus gallus)
nck1 [cytosol]
(Xenopus tropicalis)
nck-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001278928.1
,
NP_001177725.1
,
NP_006144.1
OpenTargets
ENSG00000158092
HPA
ENSG00000158092-NCK1
GeneCards
P16333
ZINC target
P16333
Ensembl
ENST00000288986
,
ENSP00000288986
,
ENST00000481752
,
ENST00000469404
,
ENSP00000419631
,
ENSP00000417273
,
ENSG00000158092
PRO
P16333
Pharos - Targets
P16333
PDB
5QU4
,
5QU8
,
2JW4
,
2JS2
,
5QU3
,
5QU7
,
2CI9
,
2CUB
,
5QU2
,
5QUA
,
5QU6
,
2JS0
,
5QU5
,
2CI8
,
5QU1
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13094 LCP2
2
p-Y113,128,145-LCP2 [cytosol]
(R-HSA-202175)
LCP2 [cytosol]
(R-HSA-202306)
0.881
21
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.823
6
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.775
6
UniProt:P07766 CD3E
2
CD3E [plasma membrane]
(R-HSA-197906)
p-Y188,Y199-CD3E [plasma membrane]
(R-HSA-202228)
0.737
6
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
0.704
4
UniProt:Q6PJG9 LRFN4
1
SALM3 [plasma membrane]
(R-HSA-197883)
0.69
11
UniProt:Q07912 TNK2
1
TNK2 [cytosol]
(R-HSA-9842568)
0.688
3
UniProt:Q07889 SOS1
3
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [plasma membrane]
(R-HSA-983559)
SOS1 [cytosol]
(R-HSA-64847)
0.688
6
UniProt:P20936 RASA1
1
RASA1 [cytosol]
(R-HSA-186833)
0.672
6
UniProt:O00401 WASL
4
N-WASP [cytosol]
(R-HSA-201873)
p-Y256-WASL [cytosol]
(R-HSA-2197672)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.669
4
UniProt:P42684 ABL2
1
ABL2 [cytosol]
(R-HSA-375998)
0.65
5
UniProt:Q92918 M4K1
0.646
4
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.643
5
UniProt:Q13285 NR5A1
3
NR5A1 [nucleoplasm]
(R-HSA-452955)
polySUMO2-K119,K194-NR5A1 [nucleoplasm]
(R-HSA-4546383)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(R-HSA-4546382)
0.609
2
UniProt:Q9ULH1 ASAP1
1
ASAP1 [cytosol]
(R-HSA-5620905)
0.609
6
UniProt:Q5WMC9 Q5WMC9
0.584
4
UniProt:Q9BYB0 SHANK3
1
SHANK3 [cytosol]
(R-HSA-6794277)
0.573
4
UniProt:P42768 WAS
2
WAS [cytosol]
(R-HSA-201879)
p-Y291-WAS [cytosol]
(R-HSA-2197668)
0.571
3
UniProt:O43516 WIPF1
1
WIPF1 [cytosol]
(R-HSA-201874)
0.564
3
UniProt:O14513 NCKP5
0.564
2
UniProt:O43150 ASAP2
0.564
2
UniProt:Q8IZP0 ABI1
2
p-5S-ABI1 [cytosol]
(R-HSA-2029034)
ABI1 [cytosol]
(R-HSA-1671643)
0.564
2
UniProt:Q9UKE5 TNIK
1
TNIK [cytosol]
(R-HSA-3214889)
0.564
2
UniProt:Q07890 SOS2
1
SOS2 [cytosol]
(R-HSA-167221)
0.564
4
UniProt:O15117 FYB
1
FYB [cytosol]
(R-HSA-390925)
0.564
3
UniProt:Q5HYW2 NHSL2
0.556
3
UniProt:P52757 CHN2
1
CHN2 [cytosol]
(R-HSA-2980572)
0.556
3
UniProt:Q9Y2H0-1 DLGAP4
0.556
3
UniProt:Q6ZUJ8-3 PIK3AP1
0.556
3
UniProt:Q9P206 NHSL3
0.547
4
UniProt:P10912 GHR
7
p-Y332,Y487,Y627-GHR(19-638) [plasma membrane]
(R-HSA-1169226)
GHR(257-638) [plasma membrane]
(R-HSA-1168803)
p-5Y-GHR(19-638) [plasma membrane]
(R-HSA-1168904)
GHR(19-638) [endosome lumen]
(R-HSA-1169263)
GHR(19-256) [extracellular region]
(R-HSA-1168821)
GHR(19-638) [plasma membrane]
(R-HSA-982779)
GHR activated [plasma membrane]
(R-HSA-1168385)
0.536
3
UniProt:Q8TF74 WIPF2
1
WIPF2 [cytosol]
(R-HSA-2197666)
0.527
3
UniProt:Q14161 GIT2
1
GIT2 [cytosol]
(R-HSA-446034)
0.527
3
UniProt:Q9HCH3 CPNE5
0.527
2
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.527
4
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.527
4
UniProt:O60500 NPHS1
2
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane]
(R-HSA-373636)
NPHS1 [plasma membrane]
(R-HSA-8981500)
0.524
3
UniProt:Q05193 DNM1
3
DNM1 [cytosol]
(R-HSA-2213182)
DNM1 [lysosomal membrane]
(R-HSA-196150)
DNM1 [plasma membrane]
(R-HSA-177488)
0.524
2
UniProt:P35968 KDR
5
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.499
3
UniProt:Q15208 STK38
1
STK38 [cytosol]
(R-HSA-9715143)
0.499
3
UniProt:Q8TAK6 OLIG1
0.488
2
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.488
2
UniProt:O60880 SH2D1A
1
SH2D1A [cytosol]
(R-HSA-5685108)
0.488
2
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