Reactome | DHF is reduced to tetrahydrofolate (THF)

DHF is reduced to tetrahydrofolate (THF)

Stable Identifier

R-HSA-197972

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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DHF is reduced to tetrahydrofolate (THF)

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Cytosolic dihydrofolate reductase catalyzes the reaction of dihydrofolate, NADPH, and H+ to form tetrahydrofolate (THF) and NADP+ (Chen et al. 1984; Davies et al. 1990).

Literature References

PubMed ID	Title	Journal	Year
2248959	Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate Freisheim, JH, Kraut, J, Prendergast, NJ, Delcamp, TJ, Ashford, VA, Davies JF, 2nd	Biochemistry	1990
6323448	The functional human dihydrofolate reductase gene Cline, A, Humphries, RK, Maizel, J, Moulton, AD, Chen, MJ, Shimada, T, Nienhuis, AW	J Biol Chem	1984