NOTCH1 stimulates MYC transcription

Stable Identifier
R-HSA-1980067
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH1 stimulates MYC transcription
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Binding of the NOTH1 Coactivator Complex to the MYC promoter stimulates MYC transcription (Palomero et al. 2006).
Literature References
PubMed ID Title Journal Year
17114293 NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

Sulis, ML, Look, AT, Palomero, T, Soulier, J, Ferrando, AA, Real, PJ, Neuberg, D, Lim, WK, Weng, AP, Sigaux, F, Margolin, A, Young, RA, O'Neil, J, Odom, DT, Aster, JC, Califano, A, Barnes, KC

Proc Natl Acad Sci U S A 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NOTCH1 Coactivator Complex:MYC Gene [nucleoplasm] (Homo sapiens)
Active Unit
NOTCH1 Coactivator Complex [nucleoplasm]
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-09)
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