Reactome | ITGA4 [plasma membrane]

ITGA4 [plasma membrane]

Stable Identifier

R-HSA-198007

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Integrin alpha-4 , ITA4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P13612 ITGA4

Gene Names

ITGA4, CD49D

Chain

signal peptide:1-33, chain:34-1032

Reference Genes

BioGPS Gene:3676 ITGA4

COSMIC (genes):ITGA4 ITGA4

CTD Gene:3676 ITGA4

dbSNP Gene:3676 ITGA4

ENSEMBL:ENSG00000115232 ITGA4

HGNC:6140 ITGA4

KEGG Gene (Homo sapiens):3676 ITGA4

Monarch:3676 ITGA4

NCBI Gene:3676 ITGA4

OMIM:192975 ITGA4

UCSC:P13612 ITGA4

Reference Transcript

Other Identifiers

0003780504

11724343_at

11724344_a_at

11724345_at

11746767_a_at

11763711_a_at

16888270

205884_at

205885_s_at

2061_at

213416_at

243366_s_at

2518281

2518282

2518283

2518284

2518285

2518287

2518288

2518294

2518296

2518298

2518299

2518300

2518301

2518304

2518305

2518306

2518308

2518312

2518313

2518314

2518316

2518318

2518327

2518329

2518333

2518334

2518335

2518336

2518338

2518339

2518341

2518342

2518343

2518345

2518346

2518347

2518348

2518349

2518350

2518351

2518352

2518353

35731_at

3676

54283_at

60314_at

65401_r_at

8046695

A_14_P132076

A_24_P915464

A_33_P3224878

A_33_P3353816

GE58240

GE595440

GO:0000902

GO:0001968

GO:0002376

GO:0002687

GO:0003366

GO:0003674

GO:0003823

GO:0005178

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005886

GO:0005925

GO:0006810

GO:0007155

GO:0007159

GO:0007160

GO:0007165

GO:0007229

GO:0008150

GO:0008219

GO:0008283

GO:0008305

GO:0009790

GO:0009986

GO:0015026

GO:0016020

GO:0016021

GO:0016192

GO:0019960

GO:0030154

GO:0030183

GO:0030198

GO:0030426

GO:0032991

GO:0033631

GO:0034113

GO:0034446

GO:0034668

GO:0034669

GO:0035987

GO:0040007

GO:0040011

GO:0043025

GO:0043113

GO:0043167

GO:0043226

GO:0046872

GO:0048646

GO:0048856

GO:0048870

GO:0050776

GO:0050839

GO:0050900

GO:0050901

GO:0050904

GO:0060385

GO:0070062

GO:0071345

GO:0090074

GO:0098657

GO:0140039

GO:1903039

GO:1903238

GO:1904646

GO:1905564

GO:1990138

GO:1990405

GO:1990771

GO:2000353

GO:2000406

HMNXSV003048166

Hs.40034.1.A1_3p_at

Hs.43936.0.A1_3p_at

Hs.43936.0.A1_3p_s_at

ILMN_1747052

PH_hs_0022595

TC02001083.hg

TC02003729.hg

X16983_at

g6006032_3p_at

g903743_3p_a_at

Participates

as a candidate of

ITGAL,(ITGA4) [plasma membrane] (Homo sapiens)

as a component of

Inferred To

ItgaPS5 [plasma membrane] (Drosophila melanogaster)

ITGA4 [plasma membrane] (Bos taurus)

ITGA4 [plasma membrane] (Canis familiaris)

ITGA4 [plasma membrane] (Sus scrofa)

Itga4 [plasma membrane] (Mus musculus)

Itga4 [plasma membrane] (Rattus norvegicus)

ItgaPS4 [plasma membrane] (Drosophila melanogaster)

Homologues of ITGA4 [plasma membrane] (Drosophila melanogaster)

scb [plasma membrane] (Drosophila melanogaster)

itga4 [plasma membrane] (Danio rerio)

itga4 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001303241.1, NP_000876.3

Guide to Pharmacology - Targets

2443

OpenTargets

ENSG00000115232

ZINC - Substances

ITA4_HUMAN

ZINC target

P13612

PRO

P13612

GlyGen

P13612

PDB

5C7Z, 4HKC, 5FPI, 3V4V, 3V4P

HPA

ENSG00000115232-ITGA4

GeneCards

P13612

Ensembl

ENST00000339307, ENST00000397033, ENSP00000340149, ENSP00000380227, ENSG00000115232

Pharos - Targets

P13612

ZINC - Predictions - Purchasable

ITA4_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.688	4
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.678	4
UniProt:P02751 FN1	10	FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-1201)-p-7Y ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.564	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	5

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