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ITGA4 [plasma membrane]
Stable Identifier
R-HSA-198007
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Integrin alpha-4 , ITA4_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
Integrin alpha4beta1 binds JAM2:JAM3 (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
integrin alpha4beta1:JAM2:JAM3 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta6:Fibronectin matrix [plasma membrane] (Homo sapiens)
Integrin alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
MADCAM1-1 binds Integrin alpha4beta7 (Homo sapiens)
Integrin alpha4beta7 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
Integrin alpha4beta7:MADCAM1 [plasma membrane] (Homo sapiens)
Integrin alpha4beta7 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
SPP1 (osteopontin) binds Integrin alpha4beta1 (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
SPP1:Integrin alpha4beta1 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1 (Homo sapiens)
Integrin alpha3beta1, alpha4beta1 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha4beta1:THBS1 trimer [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha4beta1 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
VCAM1 binds Integrin alpha4beta1 (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
integrin alpha4beta1:VCAM1 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 Regulates Immune Response and Cell Migration (Homo sapiens)
ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB (Homo sapiens)
ITGAL,(ITGA4) [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
Integrin alpha4beta1 binds JAM2:JAM3 (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
integrin alpha4beta1:JAM2:JAM3 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
ITGA4:ITGB1 binds natalizumab (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
MADCAM1-1 binds Integrin alpha4beta7 (Homo sapiens)
Integrin alpha4beta7 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
Integrin alpha4beta7:MADCAM1 [plasma membrane] (Homo sapiens)
Integrin alpha4beta7 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
VCAM1 binds Integrin alpha4beta1 (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1:natalizumab [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
integrin alpha4beta1:VCAM1 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
ITGA4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13612 ITGA4
Gene Names
ITGA4, CD49d, Integrin subunit alpha 4, CD49D
Chain
signal peptide:1-33, chain:34-1032
Reference Genes
BioGPS Gene:3676 ITGA4
COSMIC (genes):ITGA4 ITGA4
CTD Gene:3676 ITGA4
dbSNP Gene:3676 ITGA4
ENSEMBL:ENSG00000115232 ITGA4
HGNC:6140 ITGA4
KEGG:hsa:3676 ITGA4
Monarch:3676 ITGA4
NCBI Gene:3676 ITGA4
OMIM:192975 ITGA4
UCSC:P13612 ITGA4
Reference Transcript
RefSeq:NM_000885.5 ITGA4
RefSeq:NM_001316312.1 ITGA4
Other Identifiers
11724343_at
11724344_a_at
11724345_at
11746767_a_at
11763711_a_at
16888270
205884_PM_at
205884_at
205885_PM_s_at
205885_s_at
2061_at
213416_PM_at
213416_at
243366_PM_s_at
243366_s_at
243685_PM_at
243685_at
244599_PM_at
244599_at
2518281
2518282
2518283
2518284
2518285
2518286
2518287
2518288
2518289
2518290
2518294
2518295
2518296
2518297
2518298
2518299
2518300
2518301
2518302
2518304
2518305
2518306
2518308
2518309
2518310
2518311
2518312
2518313
2518314
2518316
2518317
2518318
2518327
2518328
2518329
2518333
2518334
2518335
2518336
2518337
2518338
2518339
2518341
2518342
2518343
2518345
2518346
2518347
2518348
2518349
2518350
2518351
2518352
2518353
35731_at
3676
54283_at
60314_at
61006_at
65304_at
65401_r_at
8046695
84943_at
A_14_P116556
A_14_P132076
A_24_P915464
A_33_P3224878
A_33_P3353816
GE58240
GE595440
GE632980
GO:0001968
GO:0002376
GO:0002387
GO:0002687
GO:0003013
GO:0003366
GO:0003823
GO:0005178
GO:0005515
GO:0005886
GO:0005925
GO:0007155
GO:0007159
GO:0007160
GO:0007229
GO:0008305
GO:0009897
GO:0009986
GO:0015026
GO:0016020
GO:0016192
GO:0019960
GO:0030154
GO:0030183
GO:0030426
GO:0033627
GO:0033631
GO:0034113
GO:0034446
GO:0034668
GO:0034669
GO:0035987
GO:0043025
GO:0043113
GO:0043226
GO:0045906
GO:0046872
GO:0048870
GO:0050839
GO:0050901
GO:0050904
GO:0060089
GO:0060385
GO:0070062
GO:0071345
GO:0090074
GO:0098609
GO:0098657
GO:1903039
GO:1903238
GO:1904646
GO:1905564
GO:1990138
GO:1990405
GO:1990771
GO:2000353
GO:2000406
HMNXSV003048166
Hs.164496.0.A1_3p_at
Hs.40034.1.A1_3p_at
Hs.43936.0.A1_3p_at
Hs.43936.0.A1_3p_s_at
Hs.95368.0.A1_3p_at
ILMN_1747052
PH_hs_0022595
TC02001083.hg
TC02003729.hg
X16983_at
g6006032_3p_at
g903743_3p_a_at
Participates
as a candidate of
ITGAL,(ITGA4) [plasma membrane] (Homo sapiens)
as a component of
Integrin alpha4beta7 [plasma membrane] (Homo sapiens)
ITGA4:ITGB1 [plasma membrane] (Homo sapiens)
Inferred To
ITGA4 [plasma membrane]
(Bos taurus)
ITGA4 [plasma membrane]
(Canis familiaris)
ITGA4 [plasma membrane]
(Gallus gallus)
ITGA4 [plasma membrane]
(Mus musculus)
ITGA4 [plasma membrane]
(Sus scrofa)
Itga4 [plasma membrane]
(Rattus norvegicus)
if [plasma membrane]
(Drosophila melanogaster)
pat-2 [plasma membrane]
(Caenorhabditis elegans)
itga4 [plasma membrane]
(Danio rerio)
itga4 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000876.3
,
NP_001303241.1
Guide to Pharmacology - Targets
2443
ENSEMBL
ENST00000339307
,
ENSP00000340149
,
ENSP00000380227
,
ENST00000397033
OpenTargets
ENSG00000115232
HPA
ENSG00000115232-ITGA4
ZINC - Substances
ITA4_HUMAN
ZINC target
P13612
PRO
P13612
Pharos - Targets
P13612
GlyGen
P13612
ZINC - Predictions - Purchasable
ITA4_HUMAN
PDB
5C7Z
,
3V4P
,
3V4V
,
5FPI
,
4HKC
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.688
5
UniProt:P05556 ITGB1
2
ITGB1 [plasma membrane]
(R-HSA-57596)
ITGB1 [endosome membrane]
(R-HSA-9611157)
0.678
4
UniProt:P02751 FN1
10
FN1(32-2386) [extracellular region]
(R-HSA-54851)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713459)
FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713462)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
0.564
3
UniProt:Q6UX41 BTNL8
1
BTNL8 [plasma membrane]
(R-HSA-8852007)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
5
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