ARRB mediates NOTCH1 ubiquitination

Stable Identifier
R-HSA-1980118
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Ubiquitination of NOTCH1 mediated by DTX-recruited beta-arrestins (ARRB) has not been directly studied in mammals. Non-visual beta arrestins ARRB1 and ARRB2 are known to facilitate ubiquitination and downregulation of GPCRs and IGF1R.
Literature References
PubMed ID Title Journal Year
16284625 Regulation of Notch signalling by non-visual beta-arrestin

Mukherjee, A, Bauer, A, Veraksa, A, Rosse, C, Artavanis-Tsakonas, S, Camonis, J

Nat Cell Biol 2005
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of Ubiquitin ligase [cytosol]

Inferred From
Authored
Reviewed
Created
Cite Us!